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Qiuhua Yang
Qiuhua Yang
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Jiean Xu
Jiean Xu
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Qian Ma
Qian Ma
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Zhiping Liu
Zhiping Liu
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Yaqi Zhou
Yaqi Zhou
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China
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Yongfeng Cai
Yongfeng Cai
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China
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Xiaoxiao Mao
Xiaoxiao Mao
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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David Stepp
David Stepp
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Neal Weintraub
Neal Weintraub
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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David J Fulton
David J Fulton
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Mei Hong
Mei Hong
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China
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Yuqing Huo
Yuqing Huo
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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in the inflammatory responses of both adipose and liver tissues. In vitro , the knockdown of PFKFB3 in primary HAMECs exhibits decreased PA-induced endothelial inflammation by suppressing activation of nuclear factor κB (NF-κB) signaling. Taken
A D Dobrian
A D Dobrian
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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M A Hatcher
M A Hatcher
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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J J Brotman
J J Brotman
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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E V Galkina
E V Galkina
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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P Taghavie-Moghadam
P Taghavie-Moghadam
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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H Pei
H Pei
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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B A Haynes
B A Haynes
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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J L Nadler
J L Nadler
Departments of Physiological Sciences, Microbiology and Molecular Cell Biology, Internal Medicine, Division of Inflammation Biology, Eastern Virginia Medical School, 700W Olney Road, Norfolk, Virginia 23505, USA
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Introduction Excessive accumulation of visceral adipose tissue (AT) is independently associated with cardiovascular disease ( See et al . 2007 ). In addition, the fat around the conduit vessels such as the aorta as well as the pericardial fat were
Sebastio Perrini
Sebastio Perrini
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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Luigi Laviola
Luigi Laviola
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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Marcos C Carreira
Marcos C Carreira
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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Angelo Cignarelli
Angelo Cignarelli
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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Annalisa Natalicchio
Annalisa Natalicchio
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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Francesco Giorgino
Francesco Giorgino
Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy
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thigh intermuscular adipose tissue, whereas basal GH secretion demonstrated an independent negative association with visceral adipose tissue ( Franco et al . 2006 ). Furthermore, Møller et al . (2009) have recently shown that lipid infusion during GH
Jing Zhou
Jing Zhou
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Honggui Li
Honggui Li
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Yuli Cai
Yuli Cai
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
Department of Endocrinology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
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Department of Endocrinology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
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Linqiang Ma
Linqiang Ma
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
The Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
The Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Destiny Matthews
Destiny Matthews
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Bangchao Lu
Bangchao Lu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
Department of Geriatrics, Nanjing Drum Tower Hospital, the Affiliated Nanjing Hospital of Nanjing University Medical School, Nanjing, Jiangshu, China
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Department of Geriatrics, Nanjing Drum Tower Hospital, the Affiliated Nanjing Hospital of Nanjing University Medical School, Nanjing, Jiangshu, China
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Bilian Zhu
Bilian Zhu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Yanming Chen
Yanming Chen
Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Xiaoxian Qian
Xiaoxian Qian
Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Xiaoqiu Xiao
Xiaoqiu Xiao
The Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shaodong Guo
Shaodong Guo
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Yuqing Huo
Yuqing Huo
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
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Liang Zhao
Liang Zhao
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China
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Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China
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Yanan Tian
Yanan Tian
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA
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Qingsheng Li
Qingsheng Li
Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA
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Chaodong Wu
Chaodong Wu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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. 2008 , Odegaard et al. 2008 , Menghini et al. 2009 ). In addition, obesity-associated adipose tissue dysfunction has also been implicated to play a critical role in development of NAFLD. Indeed, this role of dysfunctional adipose tissue is
Antonius Plagge
Antonius Plagge
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Gavin Kelsey
Gavin Kelsey
Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
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Emily L Germain-Lee
Emily L Germain-Lee
Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
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in brown adipose tissue: neural regulation of type III . Endocrinology 136 2007 – 2012 . Graudal N Galloe A Christensen H Olesen K 1988 The pattern of shortened hand and foot bones in D- and E-brachydactyly and
M G Gnanalingham
M G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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A Mostyn
A Mostyn
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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D S Gardner
D S Gardner
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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T Stephenson
T Stephenson
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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M E Symonds
M E Symonds
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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, spleen, thymus, macrophages, bone marrow, stomach, islets of Langerhans, skeletal muscle, heart, kidney, placenta and brain ( Ricquier & Bouillaud 2000 , Pecqueur et al. 2001 ). This recognised wide tissue distribution is based primarily on UCP2 mRNA
Gisela Helfer
Gisela Helfer
School of Chemistry and Biosciences, University of Bradford, Bradford, UK
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Qing-Feng Wu
Qing-Feng Wu
State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
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Introduction Adipokines, secreted by adipose tissue, are involved in the pathogenesis of metabolic syndrome ( Lehr et al . 2012 ). Chemerin, encoded by the gene retinoic acid receptor responder 2 ( Rarres2 ), also known as tazarotene
Aryane Cruz Oliveira Pinho
Aryane Cruz Oliveira Pinho
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Calçada Martim de Freitas, Coimbra, Portugal
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Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Calçada Martim de Freitas, Coimbra, Portugal
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Diana Santos
Diana Santos
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
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Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
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Inês Baldeiras
Inês Baldeiras
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
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Ana Burgeiro
Ana Burgeiro
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
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Emelindo C Leal
Emelindo C Leal
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
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Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
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Eugenia Carvalho
Eugenia Carvalho
Center for Neuroscience and Cell Biology (CNC), Faculty of Medicine, University of Coimbra, Rua Larga, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
APDP-Portuguese Diabetes Association, Lisbon, Portugal
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Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, Rua Dom Francisco de Lemos, Coimbra, Portugal
APDP-Portuguese Diabetes Association, Lisbon, Portugal
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Introduction Perivascular adipose tissue (PVAT) is an active endocrine organ that surrounds blood vessels, including small vessels ( Villacorta & Chang 2015 ). PVAT differs between species, and depending on the specific vascular region, it may
Samuel M Lee
Samuel M Lee
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
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Jose Muratalla
Jose Muratalla
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
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Marta Sierra-Cruz
Marta Sierra-Cruz
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
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Jose Cordoba-Chacon
Jose Cordoba-Chacon
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
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patients with NAFLD ( Fernandez-Miranda et al. 2008 ). Other examples would be thiazolidinediones (TZDs), a class of drugs that are exogenous ligands of PPARγ. TZDs activate PPARγ in adipose tissue, muscle, and liver. In adipose tissue, TZDs increase the
Zhenguang Zhang
Zhenguang Zhang
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Agnes E Coutinho
Agnes E Coutinho
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Tak Yung Man
Tak Yung Man
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Tiina M J Kipari
Tiina M J Kipari
Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK
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Patrick W F Hadoke
Patrick W F Hadoke
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Donald M Salter
Donald M Salter
Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK
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Jonathan R Seckl
Jonathan R Seckl
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Karen E Chapman
Karen E Chapman
University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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( Small et al . 2005 , McSweeney et al . 2010 , Michailidou et al . 2012 ). Global 11β-HSD1 deficiency is also pro-angiogenic in other contexts: in the sponge implantation assay ( Small et al . 2005 ); in adipose tissue of obese mice where it is
