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Jie Wei Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Xia Sun Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yajie Chen Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yuanyuan Li
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Liqiong Song
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Zhao Zhou
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Bing Xu
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Yi Lin Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Shunqing Xu
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adult male CD1 mice to BPA (0, 5, 50, 500, and 5000 μg/kg per day) resulted in the accumulation of hepatic triglycerides (TGs) and cholesteryl esters (CHOL), changes in hepatic free fatty acid (FFA) composition as well as upregulation of genes involved

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0356
Volume/Issue:
Volume 222: Issue 3
Free access
Barbara J Clark Department of Biochemistry and Molecular Biology, and the Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA

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? ? ? The thioesterase multidomain proteins STARD14 ACOT11_v2, BFIT2 Brown adipose tissue † Cytosolic c ? Fatty acid d (?) Medium chain fatty-acyl-coA hydrolysis 10 STARD15 ACOT12 Liver † Cytosolic c ? Acetyl-coA hydrolysis 11 StAR, steroidogenic acute

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0313
Volume/Issue:
Volume 212: Issue 3
Free access
Blerina Kola Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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Márta Korbonits Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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intracellular Ca 2 + levels. Ghrelin has a unique fatty acid modification on its N-terminal end as a result of the activity of the ghrelin O -acyltransferase enzyme ( Yang et al . 2008 ). However, the majority of circulating ghrelin is actually lacking this

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0056
Volume/Issue:
Volume 202: Issue 2
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Ken Takao Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Katsumi Iizuka Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yanyan Liu Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Teruaki Sakurai Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Sodai Kubota Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Saki Kubota-Okamoto Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Toshinori Imaizumi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yoshihiro Takahashi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yermek Rakhat Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Satoko Komori Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tokuyuki Hirose Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Kenta Nonomura Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Takehiro Kato Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masami Mizuno Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tetsuya Suwa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yukio Horikawa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masakatsu Sone Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

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Daisuke Yabe Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan
Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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Introduction Carbohydrate response element-binding protein (ChREBP) is critical for regulation of fatty acid and triglyceride synthesis in the liver ( Iizuka 2017 ). ChREBP has two isoforms, ChREBP-α ( Chrebpa ) and ChREBP-β ( Chrebpb

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0442
Volume/Issue:
Volume 248: Issue 3
Restricted access
Kyung-Ah Kim Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Sun-O Ka Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Woo Sung Moon Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Ho-Keun Yi Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Young-Hoon Lee Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Kang-Beom Kwon Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Jin-Woo Park Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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Byung-Hyun Park Departments of, Biochemistry, Pathology, Biochemistry, Oral Anatomy, Department of Physiology, Medical School and Institute for Medical Sciences

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-acclimated for 60 min and horizontal locomotor activity was quantified for 60 min. Plasma measurements Plasma triglyceride (TG) was measured using a glycerol phosphate oxidase-Trinder TG kit (Sigma). Plasma free fatty acid (FFA) and glycerol were measured using a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0599
Volume/Issue:
Volume 198: Issue 1
Free access
Sabina Börner
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Michael Derno
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Sandra Hacke
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Ulrike Kautzsch
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Christine Schäff
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Sint ThanThan Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Hideto Kuwayama Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Harald M Hammon
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Monika Röntgen
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Rosemarie Weikard Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Christa Kühn Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Armin Tuchscherer Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Björn Kuhla
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characterized by high body fat mobilization. This suggests that, in addition to its role in preventing starvation, ghrelin exerts a prominent role in the regulation of fat metabolism. For example, feeding rumen-protected long-chain fatty acids increases the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0384
Volume/Issue:
Volume 216: Issue 2
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Prasanthi P Koganti Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Vimal Selvaraj Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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status between the mouse and hamster adrenals, we evaluated the expression of a few core genes involved in the regulation of these processes. We found that Cpt1a , a transferase essential for mitochondrial fatty acid oxidation (FAO), was substantially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0189
Volume/Issue:
Volume 247: Issue 1
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Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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hypothesized that an increased de novo lipogenesis after fructose intake in parallel with a decreased fatty acid oxidation leads to hepatic fat deposition. ACC, acetyl-CoA-carboxylase; ATP, adenosine triphosphate; CPT1a, carnitine palmitoyltransferase 1A; FA

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0270
Volume/Issue:
Volume 257: Issue 2
Open access
Rachel Botchlett Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Pinnacle Clinical Research, Live Oak, USA

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Shih-Lung Woo Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Mengyang Liu Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Ya Pei Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Xin Guo Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Baylor College of Medicine, Houston, USA

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Honggui Li Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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the adult AMDR is a suggested intake of linoleic acid at 12–17 g/day and α-linolenic acid at 1.1–1.6 g/day, both of which are essential fatty acids and thus, cannot be synthesized innately but only obtained through the diet. High-fat diets (HFD

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0580
Volume/Issue:
Volume 233: Issue 3
Free access
Jose A Viscarra
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Cory D Champagne School of Natural Sciences, Long Marine Laboratory, Department of Biology, University of California, 5200 North Lake Road, Merced, California 95348, USA

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Daniel E Crocker School of Natural Sciences, Long Marine Laboratory, Department of Biology, University of California, 5200 North Lake Road, Merced, California 95348, USA

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Rudy M Ortiz
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gluconeogenesis (the generation of glucose from non-carbohydrate substrates), and free fatty acids, which decrease insulin sensitivity by inhibiting intracellular insulin signaling and glucose uptake, are increased in the circulation, contributing to continuation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0017
Volume/Issue:
Volume 209: Issue 3
Free access