Introduction Insulin-like growth factor (IGF)-II is a major determinant of fetal growth. Targeted disruption of the mouse IgfII gene produces proportional dwarfs, which are 60% of normal birthweight ( DeChiara et al. 1990 ). The
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Rumana Yasmeen, Qiwen Shen, Aejin Lee, Jacob H Leung, Devan Kowdley, David J DiSilvestro, Lu Xu, Kefeng Yang, Andrei Maiseyeu, Naresh C Bal, Muthu Periasamy, Paolo Fadda, and Ouliana Ziouzenkova
, Elk Grove Village, IL, USA). Gene expression quantification by NanoString nCounter assay NanoString’s nCounter (NanoString Technologies) analysis system performs direct detection of target molecules without an amplification step. Target
Wenpeng Dong, Ye Jia, Xiuxia Liu, Huan Zhang, Tie Li, Wenlin Huang, Xudong Chen, Fuchun Wang, Weixia Sun, and Hao Wu
2-related factor 2 (NRF2) has been identified as a governor of antioxidant and redox signaling. NRF2 activates the transcription of downstream antioxidant genes such as heme oxygenase-1 ( Ho1 ) and NAD(P)H dehydrogenase quinone 1 ( Nqo1 ) ( Ruiz et
Eric W-F Lam, Kunal Shah, and Jan J Brosens
pri-miRNAs and, consequently, the mRNA targets of these miRNAs were more abundantly expressed ( Yamagata et al . 2009 ). Figure 1 Biogenesis of miRNAs. Micro-RNA genes are transcribed from the genome by RNA polymerase II to generate primary
Malin Fex, Nils Wierup, Marloes Dekker Nitert, Michael Ristow, and Hindrik Mulder
Introduction Gene inactivation, using the Cre/LoxP system, is an essential technique in tissue-specific gene targeting. The rat insulin promoter 2-Cre recombinase (RIP2-Cre) mouse (also called RIP-Cre or B6.Cg-Tg (Ins2-cre) 25 Mgn
Ljupka Gligorovska, Biljana Bursać, Sanja Kovačević, Nataša Veličković, Gordana Matić, and Ana Djordjevic
-enriched diet. Glucose metabolism was assessed through analysis of systemic insulin sensitivity, while lipid metabolism was analyzed at the level of visceral adiposity, VAT histology and the expression of GC-target genes involved in lipogenesis. Besides GR
Andrea Mafficini and Aldo Scarpa
this milestone, especially with regard to targeted therapy ( Capdevila et al . 2017 , Gajate et al . 2017 ). Table 1 Genes implicated in the tumorigenesis of pancreatic neuroendocrine tumours (PanNETs) before the publication of the
Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, and Liping Luo
oligonucleotide primer pairs used in qRT-PCR analysis. Target gene Sense primer Antisense primer Chrebp 5′-CCTCACTTCACTGTGCCTCA-3′ 5′-ACAGGGGTTGTTGTCTCTGG-3′ Srebp1c 5′-GGAGCCATGGATTGCACATT-3′ 5′-GGAAGTCACTGTCTTGGTTGTTGA-3
Inga K Johnsen, Marc Slawik, Igor Shapiro, Michaela F Hartmann, Stefan A Wudy, Brendan D Looyenga, Gary D Hammer, Martin Reincke, and Felix Beuschlein
, numerous transcriptional cascades are utilized to ensure tight control over cellular proliferation and proper spatio-temporal expression of target genes. A gonadal specific target gene which is expressed in adrenal tumors of CE/J mice is the Mullerian
Vicki E Smith, Jayne A Franklyn, and Christopher J McCabe
a down-stream target for pituitary tumor-transforming gene . Journal of Biological Chemistry 276 8484 – 8491 doi:10.1074/jbc.M009654200 . Reynolds LE Watson AR Baker M Jones TA D'Amico G Robinson SD Joffre C Garrido-Urbani S
