yet been investigated in vivo. Here, we developed Prmt5 islet-specific conditional knockout (KO) mice and evaluated the impact of Prmt5 KO on islets. Notably, we found that Prmt5 KO impaired glucose tolerance (GT) and glucose stimulation
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Jian Ma, Xin He, Yan Cao, Kienan O’Dwyer, Katherine M Szigety, Yuan Wu, Buddha Gurung, Zijie Feng, Bryson W Katona, and Xianxin Hua
Toshiaki Ishizuka, Takashi Hinata, and Yasuhiro Watanabe
al . 2006 , Copple et al . 2009 ); therefore, HIF-1α induction may enhance the production of these proteins in mouse MSCs. In previous studies, the effects of high-glucose concentrations on HIF-1α expression in various mammalian cells were examined
Lin Xia, Zhongqiu Wang, Ying Zhang, Xiao Yang, Yibei Zhan, Rui Cheng, Shiming Wang, and Jianfa Zhang
Introduction Type 2 diabetes mellitus is a complex, multisystem disease with a pathophysiology that includes defects in insulin-stimulated peripheral glucose disposal and an impaired suppression of hepatic glucose production ( Matthaei et al . 2000
Neehar Gupta, Edward Park, Harmanjit Sandhu, Tracy Goh, Vaja Tchipashvili, and Adria Giacca
Introduction It is well established that insulin has direct and indirect inhibitory effects on glucose production (GP). The direct effect is due to interaction of hepatic sinusoidal insulin with the hepatocyte insulin receptor
Ruben Rodriguez, Jacqueline N Minas, Jose Pablo Vazquez-Medina, Daisuke Nakano, David G Parkes, Akira Nishiyama, and Rudy M Ortiz
myotubes, elevated angiotensin II (Ang II) levels decrease insulin-stimulated glucose uptake and glucose transporter 4 (GLUT4) translocation ( Wei et al . 2006 , 2008 , Csibi et al . 2010 ). In primary human preadipocytes, elevated Ang II levels
Yirui He, Cheng Zhang, Yong Luo, Jinhua Chen, Mengliu Yang, Ling Li, Harvest F Gu, Gangyi Yang, and Xianxiang Zhang
Introduction The global prevalence of obesity and type 2 diabetes mellitus (T2DM) is increasing. These two diseases are associated with insulin resistance (IR) and disrupted lipid and glucose metabolism ( Saltiel & Kahn 2001 ). To understand
Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby
Introduction Impaired insulin-stimulated glucose disposal into skeletal muscle is a major component of the insulin resistance (IR) that develops in advance of type 2 diabetes (T2D) ( DeFronzo & Tripathy 2009 ). In addition, obesity and IR commonly
Min Kyong Moon, In-Kyong Jeong, Tae Jung Oh, Hwa Young Ahn, Hwan Hee Kim, Young Joo Park, Hak Chul Jang, and Kyong Soo Park
the neonatal period ( Howdeshell et al . 1999 , Rubin et al . 2001 , Rubin & Soto 2009 ). However, Ryan et al . (2010) reported a contrary result that oral exposure to BPA during the perinatal period did not induce glucose intolerance later in
Maureen J Charron and Patricia M Vuguin
Introduction Glucagon is a 29-amino acid polypeptide secreted by the α or glucagon cell of the islet of Langerhans in response to hypoglycemia, arginine, gastric inhibitory polypeptide (during ambient reduced glucose levels), gastrin, and potassium
Junling He, Yi Ding, Natalia Nowik, Charel Jager, Muhamed N H Eeza, A Alia, Hans J Baelde, and Herman P Spaink
. 1999 , Funcke et al. 2014 ). Rodents lacking the gene encoding leptin are commonly characterised by hyperphagia, obesity, insulin resistance and impaired glucose tolerance. For instance, leptin -deficient mice ( ob/ob mice) exhibit the features of
