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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA
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Introduction Growth and differentiation of breast cancer is regulated by hormones, notably estrogen, progesterone and prolactin. In rodents, prolactin is a well-documented tumor promoter of the mammary gland, as revealed by a variety
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regain ( King et al. 2019 ). As a result, there is still an unmet need for other approaches to the treatment of obesity and associated T2D. The gut hormones, led by GLP-1, have emerged over the past few years as a potential answer to this need. This
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
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Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California, USA
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have shown that there is a crucial prepubertal growth period in mice during which serum thyroid levels rise; during this period, TH has a greater effect on skeletal development than growth hormone and is required for the epiphyseal ossification which
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), Amsterdam, Amsterdam, the Netherlands
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Introduction Thyroid hormone (TH) is a major determinant of basal metabolic rate as well as glucose and lipid metabolism ( Mullur et al . 2014 , Sinha et al . 2014 ). A number of recent studies have shown that in addition to the well
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Introduction Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide; rodent studies indicate it has multiple and diverse physiologic functions including a key role in the central control of energy metabolism. Intracerebroventricular
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The ability to assay small amounts of the peptide releasing hormones in biological fluids would aid greatly in the assessment of hypothalamic function. We have recently described a specific radioimmunoassay for luteinizing hormone releasing hormone (LH-RH) (Jeffcoate, Fraser, Gunn & Holland, 1973a, b) and in this study we report a radioimmunoassay for the tripeptide, thyrotrophin releasing hormone (TRH).
Thyrotrophin releasing hormone (2 mg) was conjugated to 10 mg bovine serum albumin in borate buffer pH 9·0 by the bis-diazotized benzidene method (Bassiri & Utiger, 1972 a). After 2 h at 5 °C the mixture was dialysed against distilled water for 48 h and against 0·15 m-NaCl for 24 h. This technique conjugates TRH by the imidazole ring of histidine to the protein. A sample of conjugate (2·5 mg) in saline was homogenized with Freund's complete adjuvant and injected into 20 intradermal sites in a White New Zealand rabbit.
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peripheral thyroid hormone metabolism remains to be investigated. For D2, such a differential regulation seems to exist. Recent in vitro data have demonstrated that both in rat and mouse pituitary cells D2 mRNA and activity are upregulated after
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Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
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Introduction Enteroendocrine (EE) cells are specialised hormone-secreting cells that are dispersed throughout the mucosal epithelial layer of the gastrointestinal (GI) tract. Collectively, these cells constitute 1% of the mucosal cell
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Introduction Anti-Müllerian hormone (AMH) has attracted considerable interest in female reproduction as an indicator of reproductive aging and fertility, predicting the size of follicle populations in the ovaries of women and other mammals
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Department of Human Metabolism, Robert Hague Centre for Diabetes and Endocrinology, Medical School, The University of Sheffield, Sheffield S10 2RX, UK
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, a lack of long-term placebo-controlled trials and an uncertainty regarding the underlying mechanisms of action, TRT remains controversial and its use as a protective metabolic hormone in CVD is at the centre of great debate. This review focuses on
