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Isabel C Greenman, Edith Gomez, Claire E J Moore, and Terence P Herbert

that the up-regulation of Trx2; GPx4 and peroxiredoxin-2 are important in protecting against hyperglycaemia-induced oxidative stress. Paradoxically, microarray analysis indicated that, in response to high glucose concentration, there was also an

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Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon, and Nathalie M Delzenne

oligofructose in hyperglycaemia/hypoinsulinemia has never been related to its efficiency to modify endogenous GLP-1(7–36) amide production. Therefore, the aims were to study (1) the effect of oligofructose on glucose tolerance and insulin production and (2) to

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Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, and Sofianos Andrikopoulos

Introduction The inadequate response of the body to reduce high blood glucose levels can lead to the development of type 2 diabetes. This state of hyperglycaemia is contributed by three main defects: increased glucose production from the liver, a

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Kayte A Jenkin, Lannie O'Keefe, Anna C Simcocks, Esther Grinfeld, Michael L Mathai, Andrew J McAinch, and Deanne H Hryciw

). Furthermore, obesity is a strong, independent risk factor for the development and progression of chronic kidney disease (CKD), even when confounding variables such as hyperglycaemia, diabetes or hypertension are accounted for ( Griffin et al . 2008 ). Thus

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Bernard Khoo and Tricia Mei-Mei Tan

-dependent insulinotropic polypeptide (GIP) is the partner incretin to GLP-1. GIP is secreted by neuroendocrine K cells in the duodenum and jejunum in response to nutrient ingestion. GIP is thought to have a ‘stabilizer’ effect on glucose levels: during hyperglycaemia, GIP

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B D Green, N Irwin, V A Gault, C J Bailey, F P M O’Harte, and P R Flatt

by elevated blood glucose, impaired glucose tolerance, hyperglycaemia and insulin resistance, is greatly increased in obese individuals ( Kolterman et al. 1981 , Bogardus et al. 1985 , Golay & Felber 1994 ). The role of the enteroinsular axis

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Min Zhao, Stephanie A Amiel, Michael R Christie, Paolo Muiesan, Parthi Srinivasan, Wendy Littlejohn, Mohamed Rela, Matthew Arno, Nigel Heaton, and Guo Cai Huang

to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice . Diabetologia 45 976 – 990 . Close NC Hering BJ Eggerman TL 2005 Results from the inaugural year of the

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Guillaume Mabilleau, Marie Pereira, and Chantal Chenu

. Type 2 diabetes mellitus (T2DM) is by far the most common form of DM and is characterised by chronic hyperglycaemia and hyperinsulinaemia mostly caused by insulin resistance (IR) in peripheral tissues such as the liver and muscle. The aetiology of bone

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L van Bloemendaal, J S ten Kulve, S E la Fleur, R G Ijzerman, and M Diamant

lowering postprandial hyperglycaemia, while long-acting GLP-1RA rather reduce basal hyperglycaemia ( Fineman et al . 2012 ). An important determinant of postprandial hyperglycaemia is the rate of gastric emptying. Rapid tachyphylaxis of gastric emptying

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M K Piya, P G McTernan, and S Kumar

(IGT) confers a state of chronic low-grade inflammation as well as higher cardiovascular risk. A raised HbA1c, a measure of hyperglycaemia, has been linked with increased cardiovascular mortality and morbidity in various studies ( Stratton et al . 2000