Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 91 - 100 of 1,453 items for :

  • insulin resistance x
  • Refine by access: All content x
Clear All
Patrícia Oliveira Prada Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Patrícia Oliveira Prada in
Google Scholar
PubMed Close
,
Michella Soares Coelho Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Michella Soares Coelho in
Google Scholar
PubMed Close
,
Henrique Gottardello Zecchin Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Henrique Gottardello Zecchin in
Google Scholar
PubMed Close
,
Miriam Sterman Dolnikoff Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Miriam Sterman Dolnikoff in
Google Scholar
PubMed Close
,
Alessandra Lia Gasparetti Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Alessandra Lia Gasparetti in
Google Scholar
PubMed Close
,
Luzia Naôko Shinohara Furukawa Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Luzia Naôko Shinohara Furukawa in
Google Scholar
PubMed Close
,
Mario José Abdalla Saad Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Mario José Abdalla Saad in
Google Scholar
PubMed Close
, and
Joel Claudio Heimann Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Search for other papers by Joel Claudio Heimann in
Google Scholar
PubMed Close

resistance are not yet completely understood. Under such conditions, insulin resistance may be tissue-specific to the liver and muscle, whereas adipose tissue remains sensitive to insulin, as seen in a previous study ( Hirata et al. 2003 ). At the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06028
Volume/Issue:
Volume 185: Issue 3
Free access
Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Sujith Rajan in
Google Scholar
PubMed Close
,
Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Kripa Shankar in
Google Scholar
PubMed Close
,
Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Muheeb Beg in
Google Scholar
PubMed Close
,
Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Salil Varshney in
Google Scholar
PubMed Close
,
Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Abhishek Gupta in
Google Scholar
PubMed Close
,
Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Ankita Srivastava in
Google Scholar
PubMed Close
,
Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Durgesh Kumar in
Google Scholar
PubMed Close
,
Raj K Mishra SIPS Superspeciality Hospital, Lucknow, Uttar Pradesh, India

Search for other papers by Raj K Mishra in
Google Scholar
PubMed Close
,
Zakir Hussain Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Zakir Hussain in
Google Scholar
PubMed Close
,
Jiaur R Gayen Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Jiaur R Gayen in
Google Scholar
PubMed Close
, and
Anil N Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Search for other papers by Anil N Gaikwad in
Google Scholar
PubMed Close

2015). Obesity is defined as excess accumulation of body fat or adipose tissue and is considered to be the antecedent of metabolic disorders such as insulin resistance (IR), type 2 diabetes, hypertension, dyslipidemia, cardiovascular diseases, etc. ( Ye

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0099
Volume/Issue:
Volume 230: Issue 3
Free access
Xuefeng Yang Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Xuefeng Yang in
Google Scholar
PubMed Close
,
Shuang Mei Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Shuang Mei in
Google Scholar
PubMed Close
,
Haihua Gu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Haihua Gu in
Google Scholar
PubMed Close
,
Huailan Guo Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Huailan Guo in
Google Scholar
PubMed Close
,
Longying Zha Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Longying Zha in
Google Scholar
PubMed Close
,
Junwei Cai Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Junwei Cai in
Google Scholar
PubMed Close
,
Xuefeng Li Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Xuefeng Li in
Google Scholar
PubMed Close
,
Zhenqi Liu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Zhenqi Liu in
Google Scholar
PubMed Close
, and
Wenhong Cao Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Wenhong Cao in
Google Scholar
PubMed Close

key components: insulin resistance, hyperinsulinemia, and relative insulin insufficiency. Relative insulin insufficiency (overt T2DM) typically occurs over 10 years after insulin resistance and hyperinsulinemia have been established ( Kendall et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0117
Volume/Issue:
Volume 221: Issue 3
Open access
M Schütt
Search for other papers by M Schütt in
Google Scholar
PubMed Close
,
J Zhou
Search for other papers by J Zhou in
Google Scholar
PubMed Close
,
M Meier
Search for other papers by M Meier in
Google Scholar
PubMed Close
, and
H H Klein
Search for other papers by H H Klein in
Google Scholar
PubMed Close

, however, also increasingly well established that PIs cause insulin resistance that is associated with the long-term development of a metabolic syndrome-like disease including impaired glucose tolerance/diabetes and cardiovascular complications ( Walli et

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05620
Volume/Issue:
Volume 183: Issue 3
Free access
Juthamard Surapongchai Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

Search for other papers by Juthamard Surapongchai in
Google Scholar
PubMed Close
,
Mujalin Prasannarong Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

Search for other papers by Mujalin Prasannarong in
Google Scholar
PubMed Close
,
Tepmanas Bupha-Intr Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

Search for other papers by Tepmanas Bupha-Intr in
Google Scholar
PubMed Close
, and
Vitoon Saengsirisuwan Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

Search for other papers by Vitoon Saengsirisuwan in
Google Scholar
PubMed Close

Introduction Insulin resistance of skeletal muscle represents a major defect in the maintenance of euglycemia and is often accompanied by a variety of metabolic and cardiovascular abnormalities, including glucose intolerance, hyperinsulinemia

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0579
Volume/Issue:
Volume 232: Issue 3
Free access
Sanhua Leng
Search for other papers by Sanhua Leng in
Google Scholar
PubMed Close
,
Wenshuo Zhang
Search for other papers by Wenshuo Zhang in
Google Scholar
PubMed Close
,
Yanbin Zheng
Search for other papers by Yanbin Zheng in
Google Scholar
PubMed Close
,
Ziva Liberman The Section of Endocrinology, The University of Chicago, The Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, KCBD Room 8122, 900 East 57th Street, Chicago, Illinois 60637, USA

Search for other papers by Ziva Liberman in
Google Scholar
PubMed Close
,
Christopher J Rhodes
Search for other papers by Christopher J Rhodes in
Google Scholar
PubMed Close
,
Hagit Eldar-Finkelman The Section of Endocrinology, The University of Chicago, The Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, KCBD Room 8122, 900 East 57th Street, Chicago, Illinois 60637, USA

Search for other papers by Hagit Eldar-Finkelman in
Google Scholar
PubMed Close
, and
Xiao Jian Sun
Search for other papers by Xiao Jian Sun in
Google Scholar
PubMed Close

Introduction Insulin resistance is a major pathophysiological problem in both type 1 and type 2 diabetes mellitus, and is a key component of the metabolic syndrome ( DeFronzo et al . 1982 , Fourlanos et al . 2004 ). Insulin resistance is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0456
Volume/Issue:
Volume 206: Issue 2
Free access
Jiali Liu Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA

Search for other papers by Jiali Liu in
Google Scholar
PubMed Close
,
Yue Li Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yue Li in
Google Scholar
PubMed Close
,
Xiaoyan Zhou Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Xiaoyan Zhou in
Google Scholar
PubMed Close
,
Xi Zhang Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Xi Zhang in
Google Scholar
PubMed Close
,
Hao Meng Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Hao Meng in
Google Scholar
PubMed Close
,
Sanyuan Liu Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Sanyuan Liu in
Google Scholar
PubMed Close
,
Lei Zhang Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Lei Zhang in
Google Scholar
PubMed Close
,
Juntao He Department of Health Office, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Juntao He in
Google Scholar
PubMed Close
,
Qian He Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Qian He in
Google Scholar
PubMed Close
, and
Yan Geng Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yan Geng in
Google Scholar
PubMed Close

Introduction In recent years, there has been an increasing appreciation for the significance of insulin resistance, which is a common feature of obesity and predisposes affected individuals to a variety of pathological conditions, including

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0251
Volume/Issue:
Volume 244: Issue 2
Restricted access
Fernando Escrivá Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Fernando Escrivá in
Google Scholar
PubMed Close
,
M Lucía Gavete Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by M Lucía Gavete in
Google Scholar
PubMed Close
,
Yasmín Fermín Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Yasmín Fermín in
Google Scholar
PubMed Close
,
Coralia Pérez Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Coralia Pérez in
Google Scholar
PubMed Close
,
Nilda Gallardo Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Nilda Gallardo in
Google Scholar
PubMed Close
,
Carmen Alvarez Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Carmen Alvarez in
Google Scholar
PubMed Close
,
Antonio Andrés Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Antonio Andrés in
Google Scholar
PubMed Close
,
Manuel Ros Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by Manuel Ros in
Google Scholar
PubMed Close
, and
José M Carrascosa Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

Search for other papers by José M Carrascosa in
Google Scholar
PubMed Close

reports have shown that decreased insulin sensitivity occurs in non-obese elderly humans ( Fink et al. 1983 , 1986 ), some have concluded that insulin resistance in the elderly derives from changes in body composition due to fat accumulation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07043
Volume/Issue:
Volume 194: Issue 1
Free access
P Brandimarti Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by P Brandimarti in
Google Scholar
PubMed Close
,
J M Costa-Júnior Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by J M Costa-Júnior in
Google Scholar
PubMed Close
,
S M Ferreira Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by S M Ferreira in
Google Scholar
PubMed Close
,
A O Protzek Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by A O Protzek in
Google Scholar
PubMed Close
,
G J Santos Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by G J Santos in
Google Scholar
PubMed Close
,
E M Carneiro Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by E M Carneiro in
Google Scholar
PubMed Close
,
A C Boschero Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by A C Boschero in
Google Scholar
PubMed Close
, and
L F Rezende Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

Search for other papers by L F Rezende in
Google Scholar
PubMed Close

main elements for diagnosis of type 2 diabetes, the alterations in insulin resistance, secretion, and clearance vary according to disease development. At onset of type 2 diabetes, there is an increase in insulin resistance, coupled with increased

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0177
Volume/Issue:
Volume 219: Issue 2
Free access
Cathy A Guo Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Cathy A Guo in
Google Scholar
PubMed Close
and
Shaodong Guo Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Shaodong Guo in
Google Scholar
PubMed Close

Introduction Insulin resistance is the major underlying mechanism for metabolic and cardiovascular dysfunction in obesity and type 2 diabetes mellitus (T2D) ( Qi 2016 ). T2D is a high-risk factor in promoting heart failure and its prevalence

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0679
Volume/Issue:
Volume 233: Issue 3
Free access