Search Results
Search for other papers by R Paul Robertson in
Google Scholar
PubMed
using perifusion experiments. We posited that the lack of periportal blood flow in isolated islet preparations renders the delivery of insulin to downstream alpha cells, and in turn provision of an insulin switch-off signal, impossible. As expected
Search for other papers by Kai-Chun Cheng in
Google Scholar
PubMed
Search for other papers by Ying-Xiao Li in
Google Scholar
PubMed
Search for other papers by Akihiro Asakawa in
Google Scholar
PubMed
Search for other papers by Miharu Ushikai in
Google Scholar
PubMed
Search for other papers by Ikuo Kato in
Google Scholar
PubMed
Search for other papers by Yuki Sato in
Google Scholar
PubMed
Search for other papers by Juei-Tang Cheng in
Google Scholar
PubMed
Search for other papers by Akio Inui in
Google Scholar
PubMed
insulin release and increase glucose sensitivity in terms of insulin secretion, electrical activity, and Ca 2+ signaling for changes in glucose metabolism ( Rajan et al . 1990 , Martín et al . 1999 ). Also, as shown in Fig. 4 , this action of preptin
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Maria H M Lima in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Lílian C Souza in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Luciana C Caperuto in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Estela Bevilacqua in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Alessandra L Gasparetti in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Ricardo Zanuto in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Mario J A Saad in
Google Scholar
PubMed
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
Search for other papers by Carla R O Carvalho in
Google Scholar
PubMed
activation of the extracellular signal-regulated kinase (ERK) pathway (Saltiel & Kahn 2002, Saltiel & Pessin 2002 ). Insulin has a stimulatory effect on steroidogenesis by granulosa cells from cow, rats, and women and interacts with luteinizing
Search for other papers by Thomas Nicholson in
Google Scholar
PubMed
Search for other papers by Chris Church in
Google Scholar
PubMed
Search for other papers by Kostas Tsintzas in
Google Scholar
PubMed
Search for other papers by Robert Jones in
Google Scholar
PubMed
Search for other papers by Leigh Breen in
Google Scholar
PubMed
Search for other papers by Edward T Davis in
Google Scholar
PubMed
Search for other papers by David J Baker in
Google Scholar
PubMed
Search for other papers by Simon W Jones in
Google Scholar
PubMed
effect of recombinant human vaspin on insulin signalling and glucose uptake in human skeletal muscle tissue. Materials and methods Human samples Gluteus maximus skeletal muscle, SAT and blood samples were obtained from 21 lean (BMI 22.8 ± 0
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Search for other papers by M E Cleasby in
Google Scholar
PubMed
Search for other papers by Q Lau in
Google Scholar
PubMed
Search for other papers by E Polkinghorne in
Google Scholar
PubMed
Search for other papers by S A Patel in
Google Scholar
PubMed
Search for other papers by S J Leslie in
Google Scholar
PubMed
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Search for other papers by N Turner in
Google Scholar
PubMed
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Search for other papers by G J Cooney in
Google Scholar
PubMed
Search for other papers by A Xu in
Google Scholar
PubMed
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Search for other papers by E W Kraegen in
Google Scholar
PubMed
was abolished by APPL1 down-regulation in these cells ( Mao et al . 2006 ). These data suggest that APPL1 may provide a means for crosstalk between adiponectin and insulin signalling pathways and thus a potential mechanism for the insulin
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by L B Hays in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by B Wicksteed in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by Y Wang in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by J F McCuaig in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by L H Philipson in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by J M Edwardson in
Google Scholar
PubMed
Department of Pharmacology, University of Cambridge, Cambridge, UK
Department of Pharmacology, University of Chicago, Chicago, Illinois, USA
Search for other papers by C J Rhodes in
Google Scholar
PubMed
physiologically relevant being glucose ( Lang 1999 ). The proximal signaling mechanism for glucose-stimulated insulin secretion is relatively well defined ( MacDonald 1990 ). Increased glucose metabolism in β-cells leads to an increase in the cytosolic ATP
Search for other papers by Emilio Hirsch in
Google Scholar
PubMed
Search for other papers by Carlotta Costa in
Google Scholar
PubMed
Search for other papers by Elisa Ciraolo in
Google Scholar
PubMed
distinct cell types. PI3K signaling in insulin-mediated metabolic control A growing body of evidence indicates that not only is PI3K activation a key step in insulin-mediated control of metabolism but also that PIP 3
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
Search for other papers by E Bucris in
Google Scholar
PubMed
Search for other papers by A Beck in
Google Scholar
PubMed
Search for other papers by S Boura-Halfon in
Google Scholar
PubMed
Search for other papers by R Isaac in
Google Scholar
PubMed
Search for other papers by Y Vinik in
Google Scholar
PubMed
Search for other papers by T Rosenzweig in
Google Scholar
PubMed
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
Search for other papers by S R Sampson in
Google Scholar
PubMed
Search for other papers by Y Zick in
Google Scholar
PubMed
acts as a growth factor that plays an antiapoptotic role and protects cells from death through activation of the PI3-kinase and ERK signaling pathways ( Muller et al . 2006 , Jensen & De Meyts 2009 ), and insulin therapy can protect cells from
Search for other papers by Yu Wu in
Google Scholar
PubMed
Search for other papers by Tingting Wu in
Google Scholar
PubMed
Search for other papers by Jun Wu in
Google Scholar
PubMed
Search for other papers by Lei Zhao in
Google Scholar
PubMed
Search for other papers by Qing Li in
Google Scholar
PubMed
Search for other papers by Zac Varghese in
Google Scholar
PubMed
Search for other papers by John F Moorhead in
Google Scholar
PubMed
Search for other papers by Stephen H Powis in
Google Scholar
PubMed
Search for other papers by Yaxi Chen in
Google Scholar
PubMed
Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Search for other papers by Xiong Z Ruan in
Google Scholar
PubMed
on alternate days and were culled 14 weeks after the first injection. At termination, blood samples were taken for cytokines and lipid assays, and tissue samples were collected for further detection. For biochemical analysis of insulin signaling
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Kelly D McCall in
Google Scholar
PubMed
Search for other papers by Dawn Holliday in
Google Scholar
PubMed
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Eric Dickerson in
Google Scholar
PubMed
Search for other papers by Brian Wallace in
Google Scholar
PubMed
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Anthony L Schwartz in
Google Scholar
PubMed
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Christopher Schwartz in
Google Scholar
PubMed
Search for other papers by Christopher J Lewis in
Google Scholar
PubMed
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Leonard D Kohn in
Google Scholar
PubMed
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Department of Specialty Medicine, Appalachian Rural Health Institute, Edison Biotechnology Institute, Department of Biomedical Sciences, Biomedical Engineering Program, Interthyr Corporation, Diabetes Research Center
Search for other papers by Frank L Schwartz in
Google Scholar
PubMed
inflammation and induce insulin resistance via multiple mechanisms including, but not limited to, serine phosphorylation of insulin receptor substrate-1 (IRS-1) and up-regulation of suppressors of cytokine signaling (SOCS; Paz et al . 1997 , Lin et al