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Manuel Gado Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

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Eva Tsaousidou Sabri Ülker Center for Metabolic Research, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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Stefan R Bornstein Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Diabetes and Nutritional Sciences, King's College London, London, UK

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Nikolaos Perakakis Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

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functions, such as de novo lipogenesis, protein synthesis, and downregulation of autophagy, are controlled by the mTORC1 or the MEK/ERK pathway, which are not impaired in the insulin-resistant state but rather activated due to the hyperinsulinemia. These

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Qiong Lv Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Rufei Gao Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chuan Peng School of Public Health and Management, Chongqing Medical University, Chongqing, China

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Juan Yi Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Lulu Liu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Shumin Yang Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Danting Li Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Jinbo Hu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Ting Luo Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Mei Mei Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Ying Song Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA

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Xiaoqiu Xiao School of Public Health and Management, Chongqing Medical University, Chongqing, China

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Qifu Li Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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novo lipogenesis, BPA promoted KCs polarization to pro-inflammatory M1 type with increased inflammatory factors, which may also participate in hepatic lipid deposition both in vivo and in vitro . In our study, 5, 50 and 500 µg/kg/day of BPA

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Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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) Relative mRNA expression of lipogenesis-related genes in mice scWAT ( n  = 4–8). (B and C) Lipogenesis was rescued by oltipraz treatment in Ad-Asprosin cells ( n  = 3). (B) Western blot analysis of ACC1 and FASN in the scWAT of experimental mice ( n  = 5

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Laurie Rouger Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium

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G Raphaël Denis Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium

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Souphalone Luangsay Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium

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Marc Parmentier Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium

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. Adipocyte differentiation and activity markers in ChemR23 KO mice The qRT-PCR analysis of WAT markers ( Fig. 5 A) indicated an increased expression of glycerol phosphate dehydrogenase (GPD1), an enzyme involved in lipogenesis, in 14-month-old ChemR23 KO

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Patrícia Oliveira Prada Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Michella Soares Coelho Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Henrique Gottardello Zecchin Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Miriam Sterman Dolnikoff Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Alessandra Lia Gasparetti Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Luzia Naôko Shinohara Furukawa Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Mario José Abdalla Saad Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Joel Claudio Heimann Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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kinase B) which, in turn, stimulates the glucose transport in the muscle and adipose tissue, stimulates glycogen synthesis in the liver and muscle, and stimulates lipogenesis in the adipose tissue. Therefore, the PI3-K/Akt pathway has an important role in

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Simon Lecoutre Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Barbara Deracinois Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Christine Laborie Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Delphine Eberlé Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Céline Guinez Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Polina E Panchenko INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France

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Jean Lesage Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Didier Vieau Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Claudine Junien INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France
UVSQ, Université Versailles-Saint-Quentin-en-Yvelines, Versailles, France

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Anne Gabory INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France

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Christophe Breton Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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). These studies confirmed that maternal obesity has common long-term metabolic consequences sensitizing the offspring to metabolic syndrome features. In particular, maternal obesity at conception programs enhanced adipogenesis and lipogenesis from the

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Cristina Mora Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Cristina Pintado Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain

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Blanca Rubio Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Lorena Mazuecos Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Virginia López Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Alejandro Fernández Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Aurora Salamanca Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Brenda Bárcena Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Teresa Fernández-Agulló Health Sciences Faculty, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Carmen Arribas Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain

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Nilda Gallardo Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Antonio Andrés Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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upregulation of Pparb/d and its target genes Pdk4 , Ucp3 and Acox1 . In addition, it has been recently reported that Scd1 deficiency decreased cardiac lipid content independently of PPARα by reducing lipogenesis and activating lipolysis ( Bednarski et

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Rosalba Senese
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Federica Cioffi Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Pieter de Lange
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Fernando Goglia Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Antonia Lanni
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genes involved in FA oxidation and lipogenesis respectively ( De Lange et al . 2011 ). These findings provide a clue to explain T 2 's effectiveness in lowering hepatic fat accumulation and counteracting insulin resistance with respect to T 3 . In a

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Marcelo A Christoffolete
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Márton Doleschall Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Péter Egri Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Zsolt Liposits Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Ann Marie Zavacki Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Antonio C Bianco Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Balázs Gereben Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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addition, LXR also transcriptionally controls genes associated with hepatic lipogenesis including SREBP-1c, a key regulator of fatty acid and triglyceride synthesis. On the other hand, bile acids, acting through both FXR and TGR5, decrease trigylceride

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Antonia Giacco Department of Science and Technology, University of Sannio, Benevento, Italy

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Teresa Peluso Department of Science and Technology, University of Sannio, Benevento, Italy

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Federica Cioffi Department of Science and Technology, University of Sannio, Benevento, Italy

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Stefania Iervolino Department of Science and Technology, University of Sannio, Benevento, Italy

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Giovanna Mercurio Department of Science and Technology, University of Sannio, Benevento, Italy

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Luca Roberto Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy

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Carla Reale Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy

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Marco Colella Department of Science and Technology, University of Sannio, Benevento, Italy
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy

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Mario De Felice Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy

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Maria Moreno Department of Science and Technology, University of Sannio, Benevento, Italy

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Concetta Ambrosino Department of Science and Technology, University of Sannio, Benevento, Italy
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy

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Elena Silvestri Department of Science and Technology, University of Sannio, Benevento, Italy

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the insulin and glucose sensitive genes that mediate fatty acids biosynthesis and de novo lipogenesis. We found an up-regulation of Srebp1c (+57%) and fatty acid synthase (Fas) (+43%) in Nkx2-1+/− mice and a down-regulation of acetyl-CoA carboxylase

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