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Manuel Gado
Manuel Gado
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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Eva Tsaousidou
Eva Tsaousidou
Sabri Ülker Center for Metabolic Research, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
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Stefan R Bornstein
Stefan R Bornstein
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Diabetes and Nutritional Sciences, King's College London, London, UK
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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Diabetes and Nutritional Sciences, King's College London, London, UK
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Nikolaos Perakakis
Nikolaos Perakakis
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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functions, such as de novo lipogenesis, protein synthesis, and downregulation of autophagy, are controlled by the mTORC1 or the MEK/ERK pathway, which are not impaired in the insulin-resistant state but rather activated due to the hyperinsulinemia. These
Qiong Lv
Qiong Lv
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Rufei Gao
Rufei Gao
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chuan Peng
Chuan Peng
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Juan Yi
Juan Yi
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Lulu Liu
Lulu Liu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shumin Yang
Shumin Yang
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Danting Li
Danting Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jinbo Hu
Jinbo Hu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ting Luo
Ting Luo
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Mei Mei
Mei Mei
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ying Song
Ying Song
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chaodong Wu
Chaodong Wu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Xiaoqiu Xiao
Xiaoqiu Xiao
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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novo lipogenesis, BPA promoted KCs polarization to pro-inflammatory M1 type with increased inflammatory factors, which may also participate in hepatic lipid deposition both in vivo and in vitro . In our study, 5, 50 and 500 µg/kg/day of BPA
Yanli Miao
Yanli Miao
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Haojie Qin
Haojie Qin
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Yi Zhong
Yi Zhong
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Kai Huang
Kai Huang
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Caijun Rao
Caijun Rao
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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) Relative mRNA expression of lipogenesis-related genes in mice scWAT ( n = 4–8). (B and C) Lipogenesis was rescued by oltipraz treatment in Ad-Asprosin cells ( n = 3). (B) Western blot analysis of ACC1 and FASN in the scWAT of experimental mice ( n = 5
Laurie Rouger
Laurie Rouger
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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G Raphaël Denis
G Raphaël Denis
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Souphalone Luangsay
Souphalone Luangsay
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Marc Parmentier
Marc Parmentier
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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. Adipocyte differentiation and activity markers in ChemR23 KO mice The qRT-PCR analysis of WAT markers ( Fig. 5 A) indicated an increased expression of glycerol phosphate dehydrogenase (GPD1), an enzyme involved in lipogenesis, in 14-month-old ChemR23 KO
Patrícia Oliveira Prada
Patrícia Oliveira Prada
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Michella Soares Coelho
Michella Soares Coelho
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Henrique Gottardello Zecchin
Henrique Gottardello Zecchin
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Miriam Sterman Dolnikoff
Miriam Sterman Dolnikoff
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Alessandra Lia Gasparetti
Alessandra Lia Gasparetti
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Luzia Naôko Shinohara Furukawa
Luzia Naôko Shinohara Furukawa
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Mario José Abdalla Saad
Mario José Abdalla Saad
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Joel Claudio Heimann
Joel Claudio Heimann
Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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kinase B) which, in turn, stimulates the glucose transport in the muscle and adipose tissue, stimulates glycogen synthesis in the liver and muscle, and stimulates lipogenesis in the adipose tissue. Therefore, the PI3-K/Akt pathway has an important role in
Simon Lecoutre
Simon Lecoutre
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Barbara Deracinois
Barbara Deracinois
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Christine Laborie
Christine Laborie
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Delphine Eberlé
Delphine Eberlé
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Céline Guinez
Céline Guinez
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Polina E Panchenko
Polina E Panchenko
INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France
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Jean Lesage
Jean Lesage
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Didier Vieau
Didier Vieau
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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Claudine Junien
Claudine Junien
INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France
UVSQ, Université Versailles-Saint-Quentin-en-Yvelines, Versailles, France
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UVSQ, Université Versailles-Saint-Quentin-en-Yvelines, Versailles, France
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Anne Gabory
Anne Gabory
INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France
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Christophe Breton
Christophe Breton
Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France
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). These studies confirmed that maternal obesity has common long-term metabolic consequences sensitizing the offspring to metabolic syndrome features. In particular, maternal obesity at conception programs enhanced adipogenesis and lipogenesis from the
Cristina Mora
Cristina Mora
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Cristina Pintado
Cristina Pintado
Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain
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Blanca Rubio
Blanca Rubio
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Lorena Mazuecos
Lorena Mazuecos
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Virginia López
Virginia López
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Alejandro Fernández
Alejandro Fernández
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Aurora Salamanca
Aurora Salamanca
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Brenda Bárcena
Brenda Bárcena
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Teresa Fernández-Agulló
Teresa Fernández-Agulló
Health Sciences Faculty, University Rey Juan Carlos, Alcorcón, Madrid, Spain
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Carmen Arribas
Carmen Arribas
Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain
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Nilda Gallardo
Nilda Gallardo
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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Antonio Andrés
Antonio Andrés
Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain
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upregulation of Pparb/d and its target genes Pdk4 , Ucp3 and Acox1 . In addition, it has been recently reported that Scd1 deficiency decreased cardiac lipid content independently of PPARα by reducing lipogenesis and activating lipolysis ( Bednarski et
Rosalba Senese
Rosalba Senese
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Federica Cioffi
Federica Cioffi
Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
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Pieter de Lange
Pieter de Lange
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Fernando Goglia
Fernando Goglia
Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
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Antonia Lanni
Antonia Lanni
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genes involved in FA oxidation and lipogenesis respectively ( De Lange et al . 2011 ). These findings provide a clue to explain T 2 's effectiveness in lowering hepatic fat accumulation and counteracting insulin resistance with respect to T 3 . In a
Marcelo A Christoffolete
Marcelo A Christoffolete
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Márton Doleschall
Márton Doleschall
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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Péter Egri
Péter Egri
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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Zsolt Liposits
Zsolt Liposits
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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Ann Marie Zavacki
Ann Marie Zavacki
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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Antonio C Bianco
Antonio C Bianco
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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Balázs Gereben
Balázs Gereben
Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil
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addition, LXR also transcriptionally controls genes associated with hepatic lipogenesis including SREBP-1c, a key regulator of fatty acid and triglyceride synthesis. On the other hand, bile acids, acting through both FXR and TGR5, decrease trigylceride
Antonia Giacco
Antonia Giacco
Department of Science and Technology, University of Sannio, Benevento, Italy
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Teresa Peluso
Teresa Peluso
Department of Science and Technology, University of Sannio, Benevento, Italy
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Federica Cioffi
Federica Cioffi
Department of Science and Technology, University of Sannio, Benevento, Italy
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Stefania Iervolino
Stefania Iervolino
Department of Science and Technology, University of Sannio, Benevento, Italy
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Giovanna Mercurio
Giovanna Mercurio
Department of Science and Technology, University of Sannio, Benevento, Italy
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Luca Roberto
Luca Roberto
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
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Carla Reale
Carla Reale
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
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Marco Colella
Marco Colella
Department of Science and Technology, University of Sannio, Benevento, Italy
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
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Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
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Mario De Felice
Mario De Felice
Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
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Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
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Maria Moreno
Maria Moreno
Department of Science and Technology, University of Sannio, Benevento, Italy
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Concetta Ambrosino
Concetta Ambrosino
Department of Science and Technology, University of Sannio, Benevento, Italy
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy
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Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy
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Elena Silvestri
Elena Silvestri
Department of Science and Technology, University of Sannio, Benevento, Italy
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the insulin and glucose sensitive genes that mediate fatty acids biosynthesis and de novo lipogenesis. We found an up-regulation of Srebp1c (+57%) and fatty acid synthase (Fas) (+43%) in Nkx2-1+/− mice and a down-regulation of acetyl-CoA carboxylase
