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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Diabetes and Nutritional Sciences, King's College London, London, UK
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Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
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functions, such as de novo lipogenesis, protein synthesis, and downregulation of autophagy, are controlled by the mTORC1 or the MEK/ERK pathway, which are not impaired in the insulin-resistant state but rather activated due to the hyperinsulinemia. These
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Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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novo lipogenesis, BPA promoted KCs polarization to pro-inflammatory M1 type with increased inflammatory factors, which may also participate in hepatic lipid deposition both in vivo and in vitro . In our study, 5, 50 and 500 µg/kg/day of BPA
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) Relative mRNA expression of lipogenesis-related genes in mice scWAT ( n = 4–8). (B and C) Lipogenesis was rescued by oltipraz treatment in Ad-Asprosin cells ( n = 3). (B) Western blot analysis of ACC1 and FASN in the scWAT of experimental mice ( n = 5
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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. Adipocyte differentiation and activity markers in ChemR23 KO mice The qRT-PCR analysis of WAT markers ( Fig. 5 A) indicated an increased expression of glycerol phosphate dehydrogenase (GPD1), an enzyme involved in lipogenesis, in 14-month-old ChemR23 KO
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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kinase B) which, in turn, stimulates the glucose transport in the muscle and adipose tissue, stimulates glycogen synthesis in the liver and muscle, and stimulates lipogenesis in the adipose tissue. Therefore, the PI3-K/Akt pathway has an important role in
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UVSQ, Université Versailles-Saint-Quentin-en-Yvelines, Versailles, France
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). These studies confirmed that maternal obesity has common long-term metabolic consequences sensitizing the offspring to metabolic syndrome features. In particular, maternal obesity at conception programs enhanced adipogenesis and lipogenesis from the
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upregulation of Pparb/d and its target genes Pdk4 , Ucp3 and Acox1 . In addition, it has been recently reported that Scd1 deficiency decreased cardiac lipid content independently of PPARα by reducing lipogenesis and activating lipolysis ( Bednarski et
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genes involved in FA oxidation and lipogenesis respectively ( De Lange et al . 2011 ). These findings provide a clue to explain T 2 's effectiveness in lowering hepatic fat accumulation and counteracting insulin resistance with respect to T 3 . In a
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addition, LXR also transcriptionally controls genes associated with hepatic lipogenesis including SREBP-1c, a key regulator of fatty acid and triglyceride synthesis. On the other hand, bile acids, acting through both FXR and TGR5, decrease trigylceride
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Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
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Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
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Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore',Ariano Irpino, Italy
Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy
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the insulin and glucose sensitive genes that mediate fatty acids biosynthesis and de novo lipogenesis. We found an up-regulation of Srebp1c (+57%) and fatty acid synthase (Fas) (+43%) in Nkx2-1+/− mice and a down-regulation of acetyl-CoA carboxylase