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Christian Doyon Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Pierre Samson Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Josée Lalonde Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Denis Richard Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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characteristics of the metabolic syndrome including hypertriglyceridemia, hyperinsulinemia, and insulin resistance ( Johnson et al. 1991 ). Materials and Methods Animals and treatments Lean (Fa/?) and obese ( fa / fa

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07064
Volume/Issue:
Volume 193: Issue 1
Free access
Stuart A Morgan Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Zaki K Hassan-Smith Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Craig L Doig Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Mark Sherlock Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Paul M Stewart Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK
School of Medicine, Worsley Building, University of Leeds, Leeds, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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muscle-wasting effects associated with GC excess in exogenous and endogenous Cushing’s syndrome, starvation, sepsis, and metabolic acidosis. Supplementary data This is linked to the online version of the paper at http://dx.doi.org/10.1530/JOE-16

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0011
Volume/Issue:
Volume 229: Issue 3
Free access
Abdoulaye Diane Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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Maria Kupreeva Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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Faye Borthwick Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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Spencer D Proctor Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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W David Pierce Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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Donna F Vine Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute
Metabolic and Cardiovascular Diseases Laboratory, Department of Sociology, Alberta Institute of Human Nutrition, Alberta Diabetes Institute

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ovary syndrome women . iranian Journal of Endocrinology and Metabolism 12 200 . Hart R Doherty DA Mori T Huang RC Norman RJ Franks S Sloboda D Beilin L Hickey M 2011 Extent of metabolic risk in adolescent girls with features of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0711
Volume/Issue:
Volume 226: Issue 3
Free access
Charlotte Lawson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Jose M Vicencio Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Derek M Yellon Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Sean M Davidson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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glucose levels combined with insulin resistance. The metabolic syndrome additionally comprises abdominal (central) obesity, high blood pressure, insulin resistance, and lipid abnormalities ( Perrone-Filardi et al . 2015 ). It is present in 34% of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0201
Volume/Issue:
Volume 228: Issue 2
Free access
David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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. Indeed, as PWS is the most common syndromal cause of morbid obesity ( Butler 1990 ), elucidating the aetiology of this metabolic disturbance will not only benefit individuals with PWS but also may have wider implications for ameliorating obesity

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0367
Volume/Issue:
Volume 232: Issue 1
Open access
Fabio V Comim Imperial College London, Institute of Biodiversity, Institute of Reproductive and Developmental Biology, London W12 0NN, UK

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Kate Hardy Imperial College London, Institute of Biodiversity, Institute of Reproductive and Developmental Biology, London W12 0NN, UK

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Jane Robinson Imperial College London, Institute of Biodiversity, Institute of Reproductive and Developmental Biology, London W12 0NN, UK

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Stephen Franks Imperial College London, Institute of Biodiversity, Institute of Reproductive and Developmental Biology, London W12 0NN, UK

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Bergiele AT Filandra FA Tsianateli TC Spina GG Zapanti ED Bartzis MI 1999 A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile . Journal of Clinical Endocrinology and Metabolism 84 4006

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0150
Volume/Issue:
Volume 225: Issue 1
Free access
Manon M Roustit
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Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Mark E Cleasby
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also co-exist with muscular atrophy in the elderly in the syndrome of sarcopaenic obesity ( Stenholm et al . 2008 , Narici & Maffulli 2010 , Bassil & Gougeon 2013 ). Despite this affecting between 4 and 12% of the elderly population ( Stenholm et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0181
Volume/Issue:
Volume 223: Issue 2
Open access
Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Ganesh Panzade Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Rajesh Pandey CSIR Ayurgenomics Unit-TRISUTRA, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Sanchita Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Raj Kumar Mishra SIPS Superspeciality Hospital, Lucknow, India

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Ravi Shankar Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Anil Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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at https://doi.org/10.1530/JOE-17-0387 . Discussion In this study, we have demonstrated that miR-876-3p regulates glucose homeostasis and its dysregulation leads to obesity-associated metabolic syndrome. Since no study specific to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0387
Volume/Issue:
Volume 239: Issue 1
Free access
Hanna E Auvinen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes A Romijn Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Nienke R Biermasz Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Hanno Pijl Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Louis M Havekes Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes W A Smit Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Patrick C N Rensen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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adaptations enabling the host to adequately coping with the stressor (fight or flight). Increased activity of the HPA axis has been linked to the development of the metabolic syndrome (MetS; Pasquali et al . 2006 ). The metabolic effects of GC are directed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0056
Volume/Issue:
Volume 214: Issue 2
Free access
Jerzy Bełtowski
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Grażyna Wójcicka
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Hieronim Jakubowski Department of Pathophysiology, Department of Microbiology and Molecular Genetics, Department of Biochemistry and Biotechnology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland
Department of Pathophysiology, Department of Microbiology and Molecular Genetics, Department of Biochemistry and Biotechnology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland

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amount of adipose tissue and (acquired) resistance to anorectic effect of this hormone ( Considine et al . 1996 ). Obesity and the accompanying metabolic syndrome are the major risk factors of atherosclerosis but the underlying mechanisms are

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0298
Volume/Issue:
Volume 204: Issue 2
Free access