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Caroline Davidge-Pitts Endocrine Research Unit, Kogod Center on Aging, Division of Endocrinology

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Carlos J Escande Endocrine Research Unit, Kogod Center on Aging, Division of Endocrinology

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Cheryl A Conover Endocrine Research Unit, Kogod Center on Aging, Division of Endocrinology

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±3.7 Concomitant diseases (9)  Diabetes 2  Degenerative joint disease 3  Obesity hypoventilation syndrome 3  Gastroesophageal reflux disease 2  Sleep apnea 2  Others a Medications  Diabetes 2 b  Heart/blood pressure 5 c  Heartburn 5 d  Depression 4 e  Inflammation/pain

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Dario A Gutierrez Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

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Alyssa H Hasty Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

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adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation . PNAS 106 13076 – 13081 . doi:10.1073/pnas.0903524106 . Mantovani A 1999 The chemokine system: redundancy for robust outputs

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Sylvia V H Grommen
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Lutgarde Arckens Research Group of Comparative Endocrinology, Research Group of Neuroplasticity and Neuroproteomics, Animal Physiology and Neurobiology Section, Department of Biology, K U Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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Tim Theuwissen Research Group of Comparative Endocrinology, Research Group of Neuroplasticity and Neuroproteomics, Animal Physiology and Neurobiology Section, Department of Biology, K U Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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Veerle M Darras
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Bert De Groef
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proliferation in cultured bovine thyroid cells: evidence for the involvement of epidermal growth factor-associated tyrosine kinase activity . Journal of Endocrinology 166 173 – 182 . Gauthier K Chassende O Plateroti M Roux JP Legrand C Pain B

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J Kwakkel
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O Chassande Department of Endocrinology and Metabolism, Academic Medical Center University of Amsterdam, INSERM U 577, Université Victor Segalen Bordeaux 2, F5-165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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H C van Beeren
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W M Wiersinga
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A Boelen
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for tissue-specific modulation of receptor function . EMBO Journal 15 3006 – 3015 . Gauthier K Chassande O Plateroti M Roux JP Legrand C Pain B Rousset B Weiss R Trouillas J Samarut J 1999 Different functions for the thyroid

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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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-operative pain relief, anaesthetized rats were given a s.c. injection (4 mg/kg body weight in a total volume of 0.2 ml in saline) of the non-steroidal anti-inflammatory Carprofen (Pfizer, Kent, UK). Starting 4 days after surgery, groups of ovariectomized and sham

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Xuanchun Wang Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Wei Gong Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Yu Liu Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Zhihong Yang Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Wenbai Zhou Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Mei Wang Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Zhen Yang Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Jie Wen Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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Renming Hu Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China

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libitum . All experimental procedures were approved by the Shanghai Animal Care and Use Committee on Animals and followed the policies issued by the International Association for the Study of Pain on the use of laboratory animals. All efforts were made to

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S Jeson Sangaralingham Department of Anatomy and Cell Biology, Queen’s University, Room 850, Botterell Hall, 18 Stuart Street, Kingston, Ontario, Canada K7L 3N6

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M Yat Tse Department of Anatomy and Cell Biology, Queen’s University, Room 850, Botterell Hall, 18 Stuart Street, Kingston, Ontario, Canada K7L 3N6

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Stephen C Pang Department of Anatomy and Cell Biology, Queen’s University, Room 850, Botterell Hall, 18 Stuart Street, Kingston, Ontario, Canada K7L 3N6

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.1 mg/kg) was administered every 12 h for 3 days for post-operative pain. Normal chow and water were made available ad libitum. The mice were allowed to recover for 3 days before the dietary/treatment regimen began. Dietary

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Bénédicte Rabier INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Allan J Williams INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Frederic Mallein-Gerin INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Graham R Williams INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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O Chassande INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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development of hypothyroid rats. Journal of Bone and Mineral Research 20 294 –304. Gauthier K , Chassande O, Plateroti M, Roux JP, Legrand C, Pain B, Rousset B, Weiss R, Trouillas J & Samarut J 1999 Different functions for

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F Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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V Luu-The Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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A Bélanger Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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S-X Lin Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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J Simard Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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G Pelletier Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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C Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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result in severe breast pain which may lead to discontinuation of therapy. The androgenic effect of DHEA should also be useful in reducing hot flushes. In fact, androgen therapy is successful in reducing hot flushes in hypogonadal men ( De Fazio

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Antonis Voutetakis Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Ioannis Bossis Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Marc R Kok Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Weitian Zhang Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Jianghua Wang Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Ana P Cotrim Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Changyu Zheng Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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John A Chiorini Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Lynnette K Nieman Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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Bruce J Baum Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA

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salivary and serum collections Animal studies were approved by the NIDCR Animal Care and Use Committee and the NIH Biosafety Committee. All procedures were conducted in accordance with the International Association for the Study of Pain standards

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