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Damien J Keating Prince Henry’s Institute of Medical Research, Clayton, Australia

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Chen Chen Prince Henry’s Institute of Medical Research, Clayton, Australia

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). Activin A also stimulates FSH secretion by causing membrane depolarization and the opening of Ca 2+ channels in human FSH-secreting tumor cells ( Takano et al. 1992 , Takano et al. 1994 ). Neuronal survival of rat hippocampal cultures is also

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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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-responsive Wnt gene(s) involved in stromal cell proliferation. Wnt5a expression increased in progesterone-pretreated rat uteri and the protein localized to the presumptive decidual cells. Stromal cell lines stimulated with progesterone and FGF exhibited an

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Marie-Claude Battista Service of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4

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Claude Roberge Service of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4

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Mélissa Otis Service of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4

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Nicole Gallo-Payet Service of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4

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. 2001 ), the preferential pathway of cholesterol synthesis in the human and the rat fetal brain ( Fumagalli & Paoletti 1963 ). In humans, mutations of the DHCR24 gene result in a rare and severe recessive autosomic disorder called desmosterolosis. This

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Katja J Teerds Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Human and Animal Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Department of Internal Medicine, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands

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Eddy Rijntjes Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Human and Animal Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Department of Internal Medicine, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands

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Margarita B Veldhuizen-Tsoerkan Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Human and Animal Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Department of Internal Medicine, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands

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Focko F G Rommerts Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Human and Animal Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Department of Internal Medicine, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands

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Mieke de Boer-Brouwer Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Human and Animal Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Department of Internal Medicine, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands

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progenitor cells. In order to investigate this, we have isolated interstitial cells from rat testes at three different ages reflecting different phases in this developmental process: from 10-day-old rats when in the substrain of Wistar rats used in the

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Pei-Jian He Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Masami Hirata Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Nobuhiko Yamauchi Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Masa-aki Hattori Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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), whereas P 4 inhibits E 2 -induced hyperplasia of the epithelial compartments ( Martin et al. 1973 ). In addition, P 4 acts to regulate the proliferation and differentiation of uterine stromal cells ( Rider 2002 ). Herein, we employed the rat uterus as

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K. I. J. Shennan
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M. C. Sheppard
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Neurotensin is a hypothalamic peptide which inhibits secretion of TSH in the rat in vivo. We have demonstrated a calcium-dependent release of neurotensin from incubated rat hypothalamus in response to depolarizing stimuli, as well as a dose-dependent stimulatory effect of tri-iodothyronine (T3) on neurotensin secretion. We suggest that part of the neuroendocrine control of TSH secretion involves the interaction of T3, neurotensin and TSH; the presence of neurotensin in extracts of anterior pituitary gland is further evidence for its hypophysiotrophic role.

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Daniel J Tobiansky Department of Psychology, The University of British Columbia
Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada

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George V Kachkovski Department of Psychology, The University of British Columbia

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Reilly T Enos Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA

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Kim L Schmidt Department of Psychology, The University of British Columbia

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E Angela Murphy Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA

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Kiran K Soma Department of Psychology, The University of British Columbia
Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada
Department of Zoology, The University of British Columbia, Vancouver, British Columbia, Canada

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steroid-sensitive neural circuits. The current study examines whether sucrose consumption affects metabolism, steroids, and neurochemistry in female rat dams. Female rats were fed a diet that contained a human-relevant level of sucrose (i.e. similar to

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C. E. GROSVENOR
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F. MENA
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N. S. WHITWORTH
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SUMMARY

The metabolic clearance of rat prolactin, assessed by the continuous infusion to equilibrium method, increased from 0·77 to 2·15 ml/min in lactating and from 0·65 to 1·75 ml/min in non-lactating rats as the infusion rate was increased from 100 to 472 ng/min. The clearance rate of rat prolactin did not increase when large doses of ovine prolactin were infused simutaneously with rat prolactin. The clearance rates computed from equilibrium levels of immunoreactive 131I-labelled rat prolactin in plasma were highly correlated with, but were considerably greater than, those computed from unlabelled rat prolactin which was infused simultaneously. In lactating and non-lactating rats, the clearance of each prolactin tested (RP-1, B-1, Nicoll's secreted and 131I-labelled) increased and had stabilized within the 30–35 min of infusion of each new higher dose of the hormone. The ability of the rat to clear quickly greater amounts of prolactin from the circulation as the infusion rate increases implies that plasma prolactin concentrations do not necessarily mirror the rate of prolactin secretion from the pituitary.

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Christopher R Harlow University of Edinburgh Centre for Reproductive Biology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Angela C Bradshaw University of Edinburgh Centre for Reproductive Biology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Michael T Rae University of Edinburgh Centre for Reproductive Biology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Kirsty D Shearer University of Edinburgh Centre for Reproductive Biology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Stephen G Hillier University of Edinburgh Centre for Reproductive Biology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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), chondrocytes ( Eguchi et al. 2001 ), vascular smooth muscle cells ( Fan et al. 2000 ) and renal mesengial cells ( Goppelt-Struebe et al. 2001 ). We previously showed that rat granulosa cells in preantral and early antral follicles abundantly

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Liqiong Song Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Wei Xia Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Zhao Zhou Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Yuanyuan Li Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Yi Lin Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Jie Wei Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Zhengzheng Wei Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Bing Xu Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Jie Shen Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Weiyong Li Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Shunqing Xu Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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postprandial hyperinsulinemia ( Alonso-Magdalena et al . 2006 ). Our previous studies also have demonstrated that perinatal exposure to 50 μg/kg per day BPA led to severe glucose and insulin intolerance in adult rat offspring along with progressive damage of β

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