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Bethania Mongi-Bragato Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ezequiel Grondona Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Liliana del Valle Sosa Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Natacha Zlocowski Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Clara Venier Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alicia Inés Torres Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alexandra Latini Laboratório de Bioenergética e Estresse Oxidativo – LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Universitário, Córrego Grande, Florianópolis, Brasil

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Rodrigo Bainy Leal Departamento de Bioquímica e Programa de Pós-graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

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Silvina Gutiérrez Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Lucía De Paul Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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involved in senescence growth arrest. Also, in the tumour microenvironment, SASP paracrine components such as VEGF ( Lloyd et al . 1999 , Ortiz et al. 2012 ) and matrix metalloproteinase 9 ( Turner et al. 2000 ) possibly contribute to the

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Shanqi Fu Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Miho Kuwahara Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yoko Uchida Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Sei Kondo Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Daichi Hayashi Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yuji Shimomura Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Asami Takagaki Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takashi Nishida Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yusuke Maruyama Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Mika Ikegame Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Atsuhiko Hattori Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Satoshi Kubota Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takako Hattori Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Col10a1 TGCTGCCTCAAATACCCTTTCT TGGCGTATGGGATGAAGTATTG Vegf CCTGGTAATGGCCCCTCCTC CCCCATTGCTCTGTGCCTTG Mmp13 TCCTCGGAGACTGGTAATGG TGATGAAACCTGGACAAGCA Gapdh CAATGACCCCTTCATTGACC GACAAGCTTCCCGTTCTCAG

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Anna Z Szóstek Department of Reproductive Immunology and Pathology, The Interdisciplinary Centre of Research in Animal Health, Institute of Animal Reproduction and Food Research, Olsztyn, Poland

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António M Galvão Department of Reproductive Immunology and Pathology, The Interdisciplinary Centre of Research in Animal Health, Institute of Animal Reproduction and Food Research, Olsztyn, Poland
Department of Reproductive Immunology and Pathology, The Interdisciplinary Centre of Research in Animal Health, Institute of Animal Reproduction and Food Research, Olsztyn, Poland

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Graça M Ferreira-Dias Department of Reproductive Immunology and Pathology, The Interdisciplinary Centre of Research in Animal Health, Institute of Animal Reproduction and Food Research, Olsztyn, Poland

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Dariusz J Skarzynski Department of Reproductive Immunology and Pathology, The Interdisciplinary Centre of Research in Animal Health, Institute of Animal Reproduction and Food Research, Olsztyn, Poland

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factors (VEGFs), angiopoietin-1, and angiopoietin-2 ( Tsujii et al . 1998 , Sales et al . 2002 ). Then, these factors stimulate angiogenesis by acting on endothelial cells to cause vessel sprouting and tubular structure formation ( Tsujii et al . 1998

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Misuzu Yamashita
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Fumio Otsuka
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Tomoyuki Mukai Department of Medicine and Clinical Science, Department of Rheumatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hiroyuki Otani
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Kenichi Inagaki
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Tomoko Miyoshi
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Junko Goto
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Masahiro Yamamura Department of Medicine and Clinical Science, Department of Rheumatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hirofumi Makino
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response to a number of factors including BMPs, TGFs, insulin-like growth factor-I (IGF-I), vascular endothelial growth factor (VEGF), and steroids ( McCarthy et al . 1989 , Noda & Camilliere 1989 , Celeste et al . 1990 , Midy & Plouet 1994 , Hughes

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Elisabete A Forsberg The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ileana R Botusan The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Jing Wang The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Verena Peters The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ishrath Ansurudeen The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Kerstin Brismar The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Sergiu Bogdan Catrina The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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manufacturer's instructions (Invitrogen). Real-time PCR was carried out using gene specific primer pairs for Igfbp1 (forward, 5′-ATCAGCCCATCCTGTGGAAC-3′ and reverse 5′-TGCAGCTAATCTCTCTAGCACTT-3′), Vegf a (forward, 5′-TTATGCGGATCAAACCTCAC-3′ and reverse 5

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Caitlin S Wyrwoll School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network

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expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction . Journal of Physiology 550 641 – 656 . ( https://doi.org/10.1113/jphysiol.2003.039511 ) Regnault TRH Orbus RJ de Vrijer B Davidsen ML Galan HL

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Carla Tatone Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giovanna Di Emidio Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Martina Placidi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giulia Rossi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Stefania Ruggieri Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Chiara Taccaliti Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Angela D’Alfonso Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Fernanda Amicarelli Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Maurizio Guido Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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using this model, it was demonstrated that VEGF, IL6/8, and PEDF mRNA correlated with hyperangiogenesis and chronic inflammation. Exposure to rPEDF reduced AGE-induced elevation of VEGF and IL6/8 ( Silber et al. 2020 ). In 2016, Wang et al. by

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Eduardo Esteban-Zubero Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Francisco Agustín García-Gil Department of Surgery, Gynaecology and Obstetrics, University of Zaragoza, Zaragoza, Spain

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Laura López-Pingarrón Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Moisés Alejandro Alatorre-Jiménez Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Pablo Iñigo-Gil Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Dun-Xian Tan Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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José Joaquín García Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Russel J Reiter Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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and tissue MDA levels than was oxytetracycline. The indoleamine (240mg/L orally) was also compared with hyaluronan (HA), vascular endothelial growth factor A (VEGF-A) (200ng/mL), and vitamin E (400IU/mL) in a human ovarian material study after its

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Tetsuhiro Kakimoto Safety Research Laboratory, Department I, Pharmacology Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

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Hirotaka Kimata Safety Research Laboratory, Department I, Pharmacology Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

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Satoshi Iwasaki Safety Research Laboratory, Department I, Pharmacology Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

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Atsushi Fukunari Safety Research Laboratory, Department I, Pharmacology Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

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Hiroyuki Utsumi Safety Research Laboratory, Department I, Pharmacology Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

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Tanaka M Fukunari A 2011 Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis . Journal of Toxicologic Pathology 24 137 – 142 . ( doi:10.1293/tox.24.137 ) Yoon

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Min Liu Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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Shuo Xie Department of Geriatric Medicine, Peking University First Hospital, Beijing, China

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Weiwei Liu Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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Jingjin Li Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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Chao Li Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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Wei Huang Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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Hexin Li Biological Sample Management Center, Beijing Hospital, Beijing, China

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Jinghai Song Department of Surgery, Beijing Hospital, Beijing, China

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Hong Zhang Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China

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1 receptor genes, signaling through VEGFR2 and VEGF-A bioavailability can be activated, promoting lacteal junction zippering, inhibiting chylomicron uptake, and ultimately protecting against dietary obesity ( Feng et al . 2018 ). Our results showed

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