Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 101 - 110 of 1,143 items for :

  • Refine by access: All content x
Clear All
Wenjing Wu Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Wenjing Wu in
Google Scholar
PubMed Close
,
Jiayao Fu Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Jiayao Fu in
Google Scholar
PubMed Close
,
Yijing Gu Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Yijing Gu in
Google Scholar
PubMed Close
,
Yu Wei Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Yu Wei in
Google Scholar
PubMed Close
,
Pengfei Ma Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Pengfei Ma in
Google Scholar
PubMed Close
, and
Junhua Wu Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China
Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China

Search for other papers by Junhua Wu in
Google Scholar
PubMed Close

Introduction Osteoporosis commonly occurs in postmenopausal women with estrogen deficiency and can cause serious bone loss and fractures ( Rachner et al. 2011 ). It is now known that estrogen acts directly on osteoblast lineage cells

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0518
Volume/Issue:
Volume 245: Issue 1
Restricted access
CP Carron
Search for other papers by CP Carron in
Google Scholar
PubMed Close
,
DM Meyer
Search for other papers by DM Meyer in
Google Scholar
PubMed Close
,
VW Engleman
Search for other papers by VW Engleman in
Google Scholar
PubMed Close
,
JG Rico
Search for other papers by JG Rico in
Google Scholar
PubMed Close
,
PG Ruminski
Search for other papers by PG Ruminski in
Google Scholar
PubMed Close
,
RL Ornberg
Search for other papers by RL Ornberg in
Google Scholar
PubMed Close
,
WF Westlin
Search for other papers by WF Westlin in
Google Scholar
PubMed Close
, and
GA Nickols
Search for other papers by GA Nickols in
Google Scholar
PubMed Close

Osteoclasts are actively motile on bone surfaces and undergo alternating cycles of migration and resorption. Osteoclast interaction with the extracellular matrix plays a key role in the osteoclast resorptive process and a substantial body of evidence suggests that integrin receptors are important in osteoclast function. These integrin receptors bind to the Arg-Gly-Asp (RGD) sequence found in a variety of extracellular matrix proteins and it is well established that the interaction of osteoclast alpha v beta 3 integrin with the RGD motif within bone matrix proteins is important in osteoclast-mediated bone resorption. In this study, we characterized the effects of two synthetic peptidomimetic antagonists of alpha v beta 3, SC-56631 and SC-65811, on rabbit osteoclast adhesion to purified matrix proteins and bone, and on bone resorption in vitro. SC-56631 and SC-65811 are potent inhibitors of vitronectin binding to purified alpha v beta 3. Both SC-56631 and SC-65811 inhibited osteoclast adhesion to osteopontin- and vitronectin-coated surfaces and time-lapse video microscopy showed that osteoclasts rapidly retract from osteopontin-coated surfaces when exposed to SC-56631 and SC-65811. SC-56631 and SC-65811 blocked osteoclast-mediated bone resorption in a dose-responsive manner. Further analysis showed that SC-65811 and SC-56631 reduced the number of resorption pits produced per osteoclast and the average pit size. SC-65811 was a more potent inhibitor of bone resorption and the combination of reduced pit number and size led to a 90% inhibition of bone resorption. Surprisingly, however, osteoclasts treated with SC-65811, SC-56631 or the disintegrin echistatin, at concentrations that inhibit bone resorption did not inhibit osteoclast adhesion to bone. These results suggest that alphavbeta3 antagonists inhibited bone resorption by decreasing osteoclast bone resorptive activity or efficiency but not by inhibiting osteoclast adhesion to bone per se.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1650587
Volume/Issue:
Volume 165: Issue 3
Free access
Mone Zaidi The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Mone Zaidi in
Google Scholar
PubMed Close
,
Maria I New The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Maria I New in
Google Scholar
PubMed Close
,
Harry C Blair The Pittsburgh VA Medical Center and Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Search for other papers by Harry C Blair in
Google Scholar
PubMed Close
,
Alberta Zallone Department of Histology, University of Bari, Bari, Italy

Search for other papers by Alberta Zallone in
Google Scholar
PubMed Close
,
Ramkumarie Baliram The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Ramkumarie Baliram in
Google Scholar
PubMed Close
,
Terry F Davies The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Terry F Davies in
Google Scholar
PubMed Close
,
Christopher Cardozo The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Christopher Cardozo in
Google Scholar
PubMed Close
,
James Iqbal The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by James Iqbal in
Google Scholar
PubMed Close
,
Li Sun The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Li Sun in
Google Scholar
PubMed Close
,
Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

Search for other papers by Clifford J Rosen in
Google Scholar
PubMed Close
, and
Tony Yuen The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Tony Yuen in
Google Scholar
PubMed Close

) were expressed on bone cells and that their haploinsufficiency in Tshr +/ − mice caused osteopenia without affecting the thyroid function ( Abe et al . 2003 ). Likewise, receptors for follicle-stimulating hormone (FSHRs) are expressed in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0680
Volume/Issue:
Volume 237: Issue 3
Free access
K David Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium

Search for other papers by K David in
Google Scholar
PubMed Close
,
V Dubois Basic and Translational Endocrinology, Department of Basic and Applied Medical Sciences, UGent, Ghent, Belgium

Search for other papers by V Dubois in
Google Scholar
PubMed Close
,
A Verhulst Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Search for other papers by A Verhulst in
Google Scholar
PubMed Close
,
V Sommers Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

Search for other papers by V Sommers in
Google Scholar
PubMed Close
,
D Schollaert Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven

Search for other papers by D Schollaert in
Google Scholar
PubMed Close
,
L Deboel Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven

Search for other papers by L Deboel in
Google Scholar
PubMed Close
,
K Moermans Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven

Search for other papers by K Moermans in
Google Scholar
PubMed Close
,
G Carmeliet Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven

Search for other papers by G Carmeliet in
Google Scholar
PubMed Close
,
P D’Haese Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Search for other papers by P D’Haese in
Google Scholar
PubMed Close
,
D Vanderschueren Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium

Search for other papers by D Vanderschueren in
Google Scholar
PubMed Close
,
F Claessens Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

Search for other papers by F Claessens in
Google Scholar
PubMed Close
,
P Evenepoel Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
Department of Nephrology, University Hospitals Leuven, Leuven, Belgium

Search for other papers by P Evenepoel in
Google Scholar
PubMed Close
, and
B Decallonne Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium

Search for other papers by B Decallonne in
Google Scholar
PubMed Close

Introduction Chronic kidney disease (CKD) is a very common disease affecting up to 15% of the general population, and its prevalence markedly increases with age ( https://nccd.cdc.gov/CKD/ ). Chronic kidney disease–mineral and bone disorder

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0319
Volume/Issue:
Volume 257: Issue 3
Restricted access
Chandrika D Mahalingam Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Chandrika D Mahalingam in
Google Scholar
PubMed Close
,
Tanuka Datta Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Tanuka Datta in
Google Scholar
PubMed Close
,
Rashmi V Patil Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Rashmi V Patil in
Google Scholar
PubMed Close
,
Jaclynn Kreider Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Jaclynn Kreider in
Google Scholar
PubMed Close
,
R Daniel Bonfil Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by R Daniel Bonfil in
Google Scholar
PubMed Close
,
Keith L Kirkwood Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Keith L Kirkwood in
Google Scholar
PubMed Close
,
Steven A Goldstein Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Steven A Goldstein in
Google Scholar
PubMed Close
,
Abdul B Abou-Samra Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Abdul B Abou-Samra in
Google Scholar
PubMed Close
, and
Nabanita S Datta Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

Search for other papers by Nabanita S Datta in
Google Scholar
PubMed Close

Introduction Osteoporosis, which is characterized by reduced bone mass, is a major health concern around the world. Parathyroid hormone (PTH), secreted from the parathyroid glands, is involved in calcium homeostasis and is a critical mediator of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0144
Volume/Issue:
Volume 211: Issue 2
Free access
I Suponitzky
Search for other papers by I Suponitzky in
Google Scholar
PubMed Close
and
M Weinreb
Search for other papers by M Weinreb in
Google Scholar
PubMed Close

Prostaglandin E2 (PGE2) has been shown to possess anabolic properties when administered systemically. All the experiments performed so far examined long bones from animals of varying age and bone status. In this study we compared the changes in bone mass of long bones (femur, tibia and humerus) to those in calvariae after a 3-week daily administration of 6 mg/kg PGE2 into 3-week-old rats. This regimen inhibited body weight gain (by 14.1%) as well as longitudinal growth of long bones (by 2.2-3.5%) but increased their mass. Ash weight (measuring both cancellous and compact bone) increased by 10.1-14.1% but tibial cancellous bone area was elevated by 54%. Radial growth was slightly reduced due to transient inhibition of mineral apposition rate at the periosteal envelope but the expansion of the marrow cavity was inhibited to a greater extent, resulting in an 8.1% increase in the relative compact bone area. The increased bone mass was associated with greater mechanical strength of the femoral neck (24.2% increase in fracture load and 19% in stiffness). In contrast, PGE2 administration did not affect calvarial thickness or mineral apposition rate but increased its density, i.e. reduced the area of marrow spaces due to stimulation of endocortical bone formation at this site. The pattern of bone mass changes documented in this study closely correlates with that of the induced expression of early-response genes following a single dose of PGE2 as we recently reported. These data, therefore, support the hypothesis that in vivo administration of an anabolic dose of PGE2 increases bone formation and augments bone mass largely by stimulating the recruitment of new osteoblasts via induction of the proliferation and/or differentiation of bone marrow osteogenic precursors.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1560051
Volume/Issue:
Volume 156: Issue 1
Free access
H H Farman Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by H H Farman in
Google Scholar
PubMed Close
,
K L Gustafsson Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by K L Gustafsson in
Google Scholar
PubMed Close
,
P Henning Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by P Henning in
Google Scholar
PubMed Close
,
L Grahnemo Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by L Grahnemo in
Google Scholar
PubMed Close
,
V Lionikaite Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by V Lionikaite in
Google Scholar
PubMed Close
,
S Movérare-Skrtic Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by S Movérare-Skrtic in
Google Scholar
PubMed Close
,
J Wu Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by J Wu in
Google Scholar
PubMed Close
,
H Ryberg Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by H Ryberg in
Google Scholar
PubMed Close
,
A Koskela Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

Search for other papers by A Koskela in
Google Scholar
PubMed Close
,
J Tuukkanen Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

Search for other papers by J Tuukkanen in
Google Scholar
PubMed Close
,
E R Levin Division of Endocrinology, Departments of Medicine and Biochemistry, University of California, Irvine, California, USA
The Long Beach VA Medical Center, Long Beach, California, USA

Search for other papers by E R Levin in
Google Scholar
PubMed Close
,
C Ohlsson Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by C Ohlsson in
Google Scholar
PubMed Close
, and
M K Lagerquist Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by M K Lagerquist in
Google Scholar
PubMed Close

ovariectomy of female rodents, leads to bone loss and treatment with estrogen in females protects against bone loss ( Lindsay et al. 1976 , Lindberg et al. 2002 ). In men, studies have shown that estrogens have a principal role in bone maturation and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0406
Volume/Issue:
Volume 239: Issue 3
Restricted access
M. HARRISON
Search for other papers by M. HARRISON in
Google Scholar
PubMed Close
and
RUSSELL FRASER
Search for other papers by RUSSELL FRASER in
Google Scholar
PubMed Close

SUMMARY

Pure calcium deficiency produces osteoporosis, or bone atrophy, in rats, while vitamin D deficiency as well as calcium deficiency leads to osteomalacia, or thin bones with wide osteoid seams. The retention of a dose of strontium in the osteoporotic rats is greater than normal, and this indicates rapid bone formation. The immediate cause of the bone thinning must therefore be an increase in the rate of bone resorption, contrary to the classical concepts of osteoporosis.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0210197
Volume/Issue:
Volume 21: Issue 2
Restricted access
Niklas Andersson Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Niklas Andersson in
Google Scholar
PubMed Close
,
Ulrika Islander Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Ulrika Islander in
Google Scholar
PubMed Close
,
Emil Egecioglu Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Emil Egecioglu in
Google Scholar
PubMed Close
,
Elin Löf Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Elin Löf in
Google Scholar
PubMed Close
,
Charlotte Swanson Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Charlotte Swanson in
Google Scholar
PubMed Close
,
Sofia Movérare-Skrtic Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Sofia Movérare-Skrtic in
Google Scholar
PubMed Close
,
Klara Sjögren Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Klara Sjögren in
Google Scholar
PubMed Close
,
Marie K Lindberg Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Marie K Lindberg in
Google Scholar
PubMed Close
,
Hans Carlsten Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Hans Carlsten in
Google Scholar
PubMed Close
, and
Claes Ohlsson Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborg University, Gröna stråket 8 SE-413 45 Göteborg, Sweden
Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10, SE-413 46 Göteborg, Sweden
Department of Physiology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden
Department of Pharmacology, Göteborg University, Medicinaregatan 9, Box 434 SE-405 30 Göteborg, Sweden

Search for other papers by Claes Ohlsson in
Google Scholar
PubMed Close

Introduction Estrogens are of importance for the regulation of bone metabolism in both males and females. It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06181
Volume/Issue:
Volume 187: Issue 2
Free access
Jung-Min Koh Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Jung-Min Koh in
Google Scholar
PubMed Close
,
Young-Sun Lee Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Young-Sun Lee in
Google Scholar
PubMed Close
,
Chang-Hyun Byun Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Chang-Hyun Byun in
Google Scholar
PubMed Close
,
Eun-Ju Chang Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Eun-Ju Chang in
Google Scholar
PubMed Close
,
Hyunsoo Kim Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Hyunsoo Kim in
Google Scholar
PubMed Close
,
Yong Hee Kim Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Yong Hee Kim in
Google Scholar
PubMed Close
,
Hong-Hee Kim Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Hong-Hee Kim in
Google Scholar
PubMed Close
, and
Ghi Su Kim Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Asan Institute for Life Sciences, Seoul, Republic of Korea
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul, Republic of Korea
Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

Search for other papers by Ghi Su Kim in
Google Scholar
PubMed Close

Introduction There is increasing evidence of a biochemical link between increased oxidative stress and reduced bone density. The levels of 8-iso-prostaglandin (PG) F 2 -α, a biomarker of oxidative stress, were found to be negatively

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05995
Volume/Issue:
Volume 185: Issue 3
Free access