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Vikki L Poole and Christopher J McCabe

vitro , but concerns over the systemic effects associated with retinoid use need to be carefully considered. While exogenous expression of NIS in cells has proved successful in vivo , delivery methods for gene targeting are not fully optimised and

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Femke L Groeneweg, Henk Karst, E Ron de Kloet, and Marian Joëls

: search for gene targets . European Journal of Pharmacology 583 272 – 289 doi:10.1016/j.ejphar.2007.11.070 . Di S Malcher-Lopes R Halmos KC Tasker JG 2003 Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus

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Pauline Campos, Jamie J Walker, and Patrice Mollard

) Vasileva A Jessberger R 2005 Precise hit: adeno-associated virus in gene targeting . Nature Reviews: Microbiology 3 837 – 847 . ( ) Viskaitis P Irvine EE Smith MA Choudhury AI Alvarez-Curto E

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Marianna Minnetti, Valeria Hasenmajer, Riccardo Pofi, Mary Anna Venneri, Krystallenia I Alexandraki, and Andrea M Isidori

. Drugs Indication Circadian gene target Dipeptidyl peptidase-4 inhibitors Diabetes mellitus DPP4 Gliclazide Diabetes mellitus ABCC8 and VEGFA Glimepiride Diabetes mellitus KCNJ1 and ABCC8 Insulin

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S F Ahmed and C Farquharson

gene targeting. In Molecular mechanisms to Regulate the Activities of Insulin-like Growth Factors , pp 57–63. Eds T Katano, N Hizuka & SI Takahashi. Elsevier: Amsterdam.. Wong SC Hassan K McGrogan P Weaver LT Ahmed SF 2007 The effects of

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Sunita M C De Sousa, Nèle F Lenders, Lydia S Lamb, Warrick J Inder, and Ann McCormack

-specific medical therapy does not yet exist in familial pituitary tumours, but gene-targeted treatments are rapidly evolving across medicine. PARP inhibitors, used in the treatment of patients with BRCA1/2 -mutated cancers, have been shown to decrease cell

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Yanwen Jiang, Lu Chen, Robert N Taylor, Chunjin Li, and Xu Zhou

-selective and conditional gene targeting approaches is necessary to better understand the role of these enzymes during the ovarian cycle and gestation. As previously mentioned, excess RA concentration is harmful to decidualization and implantation. Thus, actual

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Esther Isorna, Nuria de Pedro, Ana I Valenciano, Ángel L Alonso-Gómez, and María J Delgado

152 1347 – 1354 . ( doi:10.1210/en.2010-1068 ) Appelbaum L Vallone D Anzulovich A Ziv L Tom M Foulkes NS Gothilf Y 2006 Zebrafish arylalkylamine-N-acetyltranferase genes–targets for regulation of the circadian clock

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Daniel M Kelly and T Hugh Jones

). This study additionally described the inhibition of nuclear factor κB (NFκB) activation, not only as a potential mechanism for decreased VCAM-1 expression, but also as a prospective modulator of several other inflammatory gene targets known to be

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David R Grattan

function, including gene-targeting approaches that allow conditional regulation of prolactin responsive cells, will provide the impetus for a new wave of research to enhance our understanding of this fascinating system. Sixty years on from Geoffrey Harris