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Weihua Liu, Yuqiang Ji, Haiping Chu, Mo Wang, Bin Yang, and Chunyan Yin

Introduction Obesity is a chronic metabolic disorder caused by many factors, which has become the most common nutritional disorder in modern society. Obesity is a predisposing factor for metabolic diseases such as type 2 diabetes, often

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Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, and Shi-You Chen

TK Basford JE Knoll E Tong WS Blanco V Blomkalns AL Rudich S Lentsch AB Hui DY Weintraub NL 2014 HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding . Diabetes

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Monisha Rajasekaran, Ok-Joo Sul, Eun-Kyung Choi, Ji-Eun Kim, Jae-Hee Suh, and Hye-Seon Choi

-related metabolic disease is highly associated with adipose tissue macrophages (ATMs) ( Weisberg et al. 2003 ). Increased numbers of macrophages in adipose tissue are caused by macrophage infiltration and proliferation mediated by proinflammatory cytokines or

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Weiwei Xu, Jamie Morford, and Franck Mauvais-Jarvis

Introduction The role of sex in metabolic disease is a fundamental issue in endocrinology. Perhaps the most sexually dimorphic aspect of metabolic regulation is the bidirectional modulation of glucose homeostasis and energy balance by the male

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Stephanie L Clookey, Rebecca J Welly, Terese M Zidon, Michelle L Gastecki, Makenzie L Woodford, Zachary I Grunewald, Nathan C Winn, Dusti Eaton, Natalia G Karasseva, Harold S Sacks, Jaume Padilla, and Victoria J Vieira-Potter

Introduction Premenopausal females are protected against insulin resistance and adipose tissue inflammation, which are major independent predictors of metabolic disease ( Regensteiner et al. 2015 ). However, postmenopausal women exhibit a

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Yolanda Diz-Chaves, Manuel Gil-Lozano, Laura Toba, Juan Fandiño, Hugo Ogando, Lucas C González-Matías, and Federico Mallo

). There is an increased risk of glucose intolerance associated with prenatal undernutrition and impaired fetal growth in humans, which become susceptible to metabolic diseases when exposed to a calorie-rich diet. Indeed, obese children with small

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Laura L Gathercole, Nikolaos Nikolaou, Shelley E Harris, Anastasia Arvaniti, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, and Jeremy W Tomlinson

hormone and/or bile acid availability. Despite its central position, only a small number of studies have investigated AKR1D1 in the context of metabolic disease; hepatic gene expression is decreased in patients with type 2 diabetes ( Valanejad et al

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Marianna Minnetti, Valeria Hasenmajer, Riccardo Pofi, Mary Anna Venneri, Krystallenia I Alexandraki, and Andrea M Isidori

, night and shift work have been considered as risk factors for metabolic and cardiovascular disorders ( Biggi et al. 2008 ) and glucose metabolism abnormalities are described in circadian-related metabolic diseases ( Stenvers et al. 2019 ). Late

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Liselotte Fransson, Stephanie Franzén, Victoria Rosengren, Petra Wolbert, Åke Sjöholm, and Henrik Ortsäter

, Stockholm and Center for Inherited Metabolic Diseases, Karolinska University Hospital, Solna) and C-peptide levels were evaluated using ELISA (Alpco Diagnostics, Salem, NH, USA). IPinsTT and IPGTT IPinsTT and IPGTT were performed during the fourth or fifth

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Juliano C da Silveira, Ana Clara F C M de Ávila, Hannah L Garrett, Jason E Bruemmer, Quinton A Winger, and Gerrit J Bouma

Effect Species Reference miR-24 TGFβ1 EGFR RAB5B Reproductive aging, cell proliferation, and metabolic diseases Reproductive aging, cell proliferation, and metabolic diseases Decreased estradiol secretion Decreased estradiol secretion