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Shin Tsunekawa, Naoki Yamamoto, Katsura Tsukamoto, Yuji Itoh, Yukiko Kaneko, Toshihide Kimura, Yoh Ariyoshi, Yoshitaka Miura, Yutaka Oiso, and Ichiro Niki

participate in the pathogenesis of diabetes mellitus ( Donath et al. 1999 , Mandrup-Poulsen 2003 , Scheuner et al. 2005 ). Among them, more attention has recently been directed to endoplasmic reticulum (ER) stress. ER stress is a series of cellular

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David A Baltzegar, Benjamin J Reading, Jonathon D Douros, and Russell J Borski

discrete roles of mobilizing energy during periods of stress or catabolism among vertebrate groups. Two leptin paralogs ( lepa and lepb ) exist in many teleosts, suggesting genome duplication as a potential mechanism of functional divergence ( Gorissen

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Parveen Abidi, Haiyan Zhang, Syed M Zaidi, Wen-Jun Shen, Susan Leers-Sucheta, Yuan Cortez, Jiahuai Han, and Salman Azhar

steroidogenic function is accompanied by a significant alteration in oxidative status of rat adrenal and testicular tissues including enhanced oxidative stress, loss of enzymatic and non-enzymatic antioxidants and increased membrane lipid peroxidation ( Azhar

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Martha Lappas, Amberlee Mittion, and Michael Permezel

a reduced capacity to respond to oxidative stress in terms of 8-isoprostane (marker of lipid peroxidation) and tumour necrosis factor α (TNFα) release ( Coughlan et al . 2004 b ). We concluded that GDM placenta may be pre-conditioned by transient

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Chad Osterlund and Robert L Spencer

negative feedback function associated with a wide range of clinical disorders (e.g. depression, post-traumatic stress disorder, type II diabetes, chronic fatigue syndrome, fibromyalgia, and chronic facial pain) and associated precursor conditions (e

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Kotaro Horiguchi, Tom Kouki, Ken Fujiwara, Takehiro Tsukada, Floren Ly, Motoshi Kikuchi, and Takashi Yashiro

identify the mechanism responsible for the extension of FS cell cytoplasmic processes. First, we observed stress fiber formation in FS cells in the presence of laminin, an ECM component of the basement membrane. Stress fibers are composed of bundles of 10

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Qingling Huang, Elena Timofeeva, and Denis Richard

). After a session of treadmill running, about all PVN CRFergic neurons express the immediate early gene c-fos , a marker of persisting neuronal activity ( Timofeeva et al. 2003 ). Besides its stress-related hypophysiotropic effects, CRF blunts energy

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Joanna Klubo-Gwiezdzinska, Kirk Jensen, Andrew Bauer, Aneeta Patel, John Costello Jr, Kenneth D Burman, Leonard Wartofsky, Matthew J Hardwick, and Vasyl V Vasko

Coulter (Fullerton, CA, USA). For induction of oxidative stress, thyroid cancer cells were treated with H 2 O 2 . H 2 O 2 stock solution (100 mM) was added into cell culture medium to achieve the desired working concentration. For TSPO ligand studies, PK

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I. Pollard


Persistent effects of stress were found in second generation rats bred from females whose own mothers had been stressed during pregnancy. The second generation rats grew more slowly, with a plateau in the growth being reached at the same age as in the controls. This resulted in adult animals of both sexes being permanently smaller than their control counterparts. When these offspring were subjected to short-term stress (one session) in adulthood, the response was not significantly different to that for the controls, indicating an intact emergency response. The male offspring from the stressed group, however, had a significantly (P < 0·01) higher plasma progesterone concentration, and a significantly (P < 0·01) lower testicular enzymic 3β-hydroxysteroid dehydrogenase activity at rest, when compared with the control offspring. The fertility of the mature female from the stressed group was not affected as a third generation of litters born did not differ from the controls.

It is suggested that a changed genetic programme in the ovarian germ cells of the first generation and/or a changed uterine environment in the second generation may be implicated.

J. Endocr. (1986) 109, 239–244

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Mitra Arianmanesh, Rebecca H McIntosh, Richard G Lea, Paul A Fowler, and Kaïs H Al-Gubory

versus P12 P20 versus P16 P12 versus C12 P16 versus C16 P16 versus C12 Structural proteins  VIM 1 53.8 5.06 828 P48616 +7.89 +2.75 −2.53 −1.67 −4.81 +1.63 7 52.9 5.10 156  LMNA 584 12.1 9.02 330 Q3SZI2 −1.87 +1.05 +1.41 −1.46 +1.35 −1.38 Oxidative stress