cirrhosis. The dyslipidaemia is frequently bad enough to lead to eruptive xanthomata and pancreatitis. Splenomegaly is common. Serum adiponectin, sex hormone-binding globulin and insulin-like growth factor binding protein 1 are typically suppressed and can
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Isabel Huang-Doran, Alison Sleigh, Justin J Rochford, Stephen O'Rahilly, and David B Savage
Sean A Newsom, Jennifer C Richards, Tyler K Johnson, Jessica N Kuzma, Mark C Lonac, Roger J Paxton, Grant M Rynn, Wyatt F Voyles, and Christopher Bell
, plasma concentrations of adiponectin (CV within: 4.1%; CV between: 7.9%), pigment epithelium-derived factor (PEDF; CV within: 5.6%; CV between: 6.3%), and insulin (CV within: 5.2%; CV between: 8.1%; all assays purchased from Millipore Corporation
Sebastian Weise, Susan Kralisch, Grit Sommer, Ulrike Lossner, Matthias Bluher, Michael Stumvoll, and Mathias Fasshauer
-established inhibitors of insulin signal transduction ( Fasshauer et al . 2004 ). In addition, IL-1β dramatically decreased the production of the insulin-sensitizing adipokine adiponectin in 3T3-L1 adipocytes and in human primary fat cells ( Lagathu et al . 2006
Maria Namwanje, Longhua Liu, Michelle Chan, Nikki Aaron, Michael J Kraakman, and Li Qiang
deletion of Cbp and/or p300 using the adiponectin-Cre recombinase. While the adipose loss of p300 did not have a significant impact on adipose remodeling, the loss of Cbp selectively induced browning in inguinal WAT and reduced both adipose tissue
T Mracek, D Gao, T Tzanavari, Y Bao, X Xiao, C Stocker, P Trayhurn, and C Bing
suggests that altered production of adipose-derived protein factors (adipokines), such as leptin, tumour necrosis factor-α (TNFα), adiponectin and chemerin, plays an important role. Zinc-α2-glycoprotein (ZAG, also called AZGP1) is a secreted, soluble
Andrea Stojakovic, Enma P Espinosa, Osman T Farhad, and Kabirullah Lutfy
, energy expenditure and feeding behavior ( Scherer et al . 1995 ). Adiponectin, an adipokine secreted by the white adipose tissue (WAT), and present at high concentrations in the circulation, has been shown to be negatively correlated with body weight
M Skrzypski, M Billert, K W Nowak, and M Z Strowski
, insulin sensitivity and play a role in the pathophysiology of obesity ( Ouchi et al . 2011 ). We reported that orexin A can stimulate expression and secretion of adiponectin in 3T3-L1 adipocytes ( Skrzypski et al . 2011 ). Furthermore, orexin A
Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, Stephanie Li Ying Soh, Guanghou Shui, Markus R Wenk, Kevin L Grove, George K Radda, Weiping Han, and Xiaoqiu Xiao
was confirmed using an Agilent 2100 Bioanalyzer. For mRNA quantification, both TaqMan and SYBR Green methods were used. Inventoried TaqMan primers and probes for adiponectin, DAG acyltransferase-2 (DGAT2), fatty acid synthase (FAS), glucose transporter
Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, and Mary E Wlodek
/kg body weight) and Ilium Xylazil-20 (30 mg/kg body weight) and blood collected for determination of plasma glucose, insulin, triglyceride, estradiol (E 2 ), adiponectin and leptin. Pancreas, liver, dorsal fat, and hindlimb leg muscles (soleus, extensor
Li Zhao, Chunfang Zhu, Meng Lu, Chi Chen, Xiaomin Nie, Buatikamu Abudukerimu, Kun Zhang, Zhiyuan Ning, Yi Chen, Jing Cheng, Fangzhen Xia, Ningjian Wang, Michael D Jensen, and Yingli Lu
blood glucose (FBG) and FINS levels using the following formulas: HOMA-IR = FBG × FINS/22.5 and ISI = ln(1/(FBG × FINS)) ( Zhao et al . 2017 ). After 12 weeks of treatment, leptin and adiponectin levels were also assayed with ELISA kits (Crystal, USA
