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Srividya Vasu SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Mary K McGahon Centre for Experimental Medicine, Queens University of Belfast, Belfast, UK

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R Charlotte Moffett SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Tim M Curtis Centre for Experimental Medicine, Queens University of Belfast, Belfast, UK

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J Michael Conlon SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Yasser H A Abdel-Wahab SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Peter R Flatt SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Introduction Incidence of type 2 diabetes is constantly on the rise, owing to an increase in consumption of a Western diet, sedentary lifestyle, obesity and ageing population ( Stumvoll et al. 2008 , McCarthy 2011 ). Current therapies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0453
Volume/Issue:
Volume 232: Issue 3
Free access
Anna Cinkajzlová Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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2010 ). Excessive accumulation of VAT phenotypically presented as android obesity is associated with higher metabolic risk and the development of insulin resistance, arterial hypertension, type 2 diabetes mellitus (T2DM) and cardiovascular diseases

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0159
Volume/Issue:
Volume 252: Issue 1
Free access
Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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reversible with weight loss ( Grossmann 2018 ) and does not demonstrate androgen deficiency. Although weight loss will both increase serum testosterone and prevent type 2 diabetes (T2D), it is unclear whether this effect is mediated directly by the increase

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0223
Volume/Issue:
Volume 258: Issue 3
Free access
G Üçkaya
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P Delagrange
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A Chavanieu
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G Grassy
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M-F Berthault
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A Ktorza
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E Cerasi
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G Leibowitz
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N Kaiser
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Introduction Type 2 diabetes results from failure to increase insulin secretion in the face of insulin resistance ( Cerasi 1995 , Kahn 2003 ). Studies in humans and animal models of type 2 diabetes show marked β-cell dysfunction

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05818
Volume/Issue:
Volume 184: Issue 3
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Sojin Lee Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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H Henry Dong Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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mutations in FoxO genes or altered expression of FoxO proteins are associated with diseases including diabetes and cancer or with reduced lifespan in mammals. This latter aspect is exemplified by the illustration of role of the FoxO ortholog Daf16 in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0002
Volume/Issue:
Volume 233: Issue 2
Free access
Sergio Di Meo Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Susanna Iossa Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Paola Venditti Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Introduction In recent years, the observation that insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are growing dramatically all over the world has stimulated the research on such metabolic disorders and their possible therapy. At

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0598
Volume/Issue:
Volume 233: Issue 1
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Thanh Q Dang Department of Biology, Faculty of Science York University, Toronto, Canada

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Nanyoung Yoon Department of Biology, Faculty of Science York University, Toronto, Canada

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Helen Chasiotis Department of Biology, Faculty of Science York University, Toronto, Canada

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Emily C Dunford School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Qilong Feng Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Pingnian He Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Michael C Riddell School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Scott P Kelly Department of Biology, Faculty of Science York University, Toronto, Canada

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Gary Sweeney Department of Biology, Faculty of Science York University, Toronto, Canada

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potent effects on restricting endothelial transport ( Felinski & Antonetti 2005 , Witt & Sandoval 2014 ), and they contribute to the development of diabetes at least in part by increasing hepatic glucose production and reducing GLUT4 translocation in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0363
Volume/Issue:
Volume 234: Issue 2
Free access
Ling He Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Shumei Meng Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Emily L Germain-Lee Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Sally Radovick Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Fredric E Wondisford Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Introduction Diabetes mellitus is increasing in prevalence worldwide due to dietary excesses and sedentary lifestyles. About 25.8 million individuals in the USA have diabetes, accounting for 8.3% of the population. Type 2 diabetes previously was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0084
Volume/Issue:
Volume 221: Issue 3
Free access
Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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GLP-1R activation ( Baggio et al. 2004 ). Further, oxyntomodulin production is blunted in individuals with type 2 diabetes (T2D) ( Wewer Albrechtsen et al. 2016 ), and treatment with oxyntomodulin is beneficial for glucose homeostasis via the

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0019
Volume/Issue:
Volume 258: Issue 2
Free access
Morten Lundh Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Marco Bugliani Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Tina Dahlby Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Danny Hung-Chieh Chou Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Bridget Wagner Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Seyed Mojtaba Ghiasi Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Vincenzo De Tata Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Zhifei Chen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Marianne Nissan Lund Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Food Science, University of Copenhagen, Copenhagen, Denmark

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Michael J Davies Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Piero Marchetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Thomas Mandrup-Poulsen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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animal models, and our study clarifies the translational potential of this concept, in that our data in human islets do not support the use of inhibitors selective for the i-proteasome in diabetes. In conclusion, beta cells upregulate immunoproteasome

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0110
Volume/Issue:
Volume 233: Issue 3
Free access