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Hyun Joon Kim, Mary C Gieske, Kourtney L Trudgen, Susan Hudgins-Spivey, Beob Gyun Kim, Andree Krust, Pierre Chambon, Jae-Wook Jeong, Eric Blalock, and CheMyong Ko

well-established regulation of ion transport, which has been thought to be an important regulatory mechanism in release of hormones and neurotransmitters ( Douglas & Rubin 1961 , Stojilkovic et al . 2005 , Qiu et al . 2006 , Stojilkovic 2006 ), and

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Catalina Sierra-Ramos, Silvia Velazquez-Garcia, Arianna Vastola-Mascolo, Guadalberto Hernández, Nourdine Faresse, and Diego Alvarez de la Rosa

( Kobayashi & Cohen 1999 ). The purified BAC insert was used for pronuclear injection of (C57BL/6J × SJL/J) F2 embryos. Founder animals harboring the transgene were backcrossed with C57BL/6 mice for nine generations to produce the B6.Tg.sgk1 line. Mice

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Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, and Lucila L K Elias

Schwartz MW 1993 Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain . Journal of Clinical Investigation 92 . (

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Christopher J Burns, Shanta J Persaud, and Peter M Jones

seemingly idealistic, many aspects of this scenario are already possible. Human embryos have been cloned using nuclei from somatic cells ( Hwang et al. 2004 ), although there are unresolved ethical and legal issues with this process. Pluripotent human ES

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J A Tamblyn, M Hewison, C L Wagner, J N Bulmer, and M D Kilby

locally generated 1,25(OH) 2 D within the maternal and fetal utero-placental tissues. One possibility is that 1,25(OH) 2 D generated by either the placenta or decidua acts to facilitate the transport of calcium and/or phosphate across the placenta to

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Kimberley C W Wang, Kimberley J Botting, Song Zhang, I Caroline McMillen, Doug A Brooks, and Janna L Morrison

of GLUT-4-containing vesicles to the sarcolemma for the transport of glucose into cardiomyocytes ( Sano et al . 2003 ). However, a rapid shift from glucose to fatty acid metabolism occurs in the postnatal period, where thereafter fatty acids

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Laura D Brown

) population in the developing human embryo ( Pittenger et al . 1999 ). Because both myocytes and adipocytes share a common progenitor, the milieu of nutrients and growth factors in early embryonic and fetal life could affect MSC commitment to either a

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Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

hormone-producing cell types ( Lanctot et al . 1999 ). Pitx1 null embryos have normal pituitary morphogenesis; however, at birth the number of thyrotropes and gonadotropes are reduced. This absence of early defects may in part be explained by the

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Christoph Schmid, Marian C Neidert, Oliver Tschopp, Lisa Sze, and René L Bernays

hippocampus, disturbed axonal transport and hippocampus degeneration and impaired myelin production in specific areas of the brain ( Nagai et al . 2003 , Li et al . 2004 , Shiozaki et al . 2008 , Chen et al . 2013 a ). A recent study suggested that

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Anne M Houbrechts, Jolien Van houcke, and Veerle M Darras

homozygous mutant zebrafish were maintained in circulating freshwater aquaria at 27.5 ± 1°C under a 14L/10D regimen. Fish were fed ad libitum with formulated feed in the morning and Artemia salina larvae in the evening. Embryos and larvae (until 7 days