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Julie Rodriguez Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium

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Nathalie M Delzenne Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium

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/80, Il6, Mcp1, Il6, NFkB ) ↓ Lipogenesis ( Fasn ) ↓ Fatty acid oxidation ( Pparγ ) ↓ Adipocytes differentiation (C/EBPα) Neyrinck et al . 2011 HF-fed mice Arabinoxylans AX for 4 weeks 4 weeks HF-AX vs HF (qPCR): ↑ Bifidobacterium spp

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-20-0499
Volume/Issue:
Volume 249: Issue 1
Free access
Kook Hwan Kim Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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Myung-Shik Lee Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea
Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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are major targets of systemic actions of FGF21 in metabolic improvement, although direct repressive effects of FGF21 on gluconeogenesis and lipogenesis in the liver have also been reported ( Zhang et al . 2011 , Kong et al . 2013 ). The importance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0160
Volume/Issue:
Volume 226: Issue 1
Free access
Marleen B Dommerholt Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada
Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Derek A Dionne Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada

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Daria F Hutchinson Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada

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Janine K Kruit Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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James D Johnson Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada

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4 and Prdm16 , genes involved in thermogenesis, tended to be decreased, as well as genes involved in lipogenesis and adipogenesis such as Pparg, Fas and Acaca ( Fig. 1N ). Therefore, based on our gene expression data with these C57BL/6J mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0505
Volume/Issue:
Volume 237: Issue 1
Free access
Patricia K Russell Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Salvatore Mangiafico Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Barbara C Fam Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Michele V Clarke Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Evelyn S Marin Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Sofianos Andrikopoulos Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Kristine M Wiren Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
Departments of Medicine and Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA

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Jeffrey D Zajac Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Rachel A Davey Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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important in adipogenesis, lipogenesis, lipolysis, fatty acid metabolism, inflammation and energy balance and regulation. In retroperitoneal VAT, the expression of the PPARα, Scd1 (stearoyl-coenzyme A desaturase 1) , Cepbα, Acaca (acetyl-coenzyme A

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0656
Volume/Issue:
Volume 237: Issue 1
Free access
Lewin Small Diabetes and Metabolism Division, Garvan Institute, Sydney, New South Wales, Australia

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Henry Gong The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia

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Christian Yassmin The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia

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Gregory J Cooney Diabetes and Metabolism Division, Garvan Institute, Sydney, New South Wales, Australia
The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia

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Amanda E Brandon Diabetes and Metabolism Division, Garvan Institute, Sydney, New South Wales, Australia
The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia

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). Corresponding to the elevated triglyceride content, the enzymes of the lipogenesis pathway ACC ( Fig. 4D ), FAS ( Fig. 4E ) and SCD1 ( Fig. 4F ) were elevated in the livers of mice housed at 29°C, due largely to a significant effect in chow-fed animals. The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0279
Volume/Issue:
Volume 239: Issue 3
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Rumana Yasmeen Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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Qiwen Shen Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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Aejin Lee Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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Jacob H Leung Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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Devan Kowdley Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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David J DiSilvestro Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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Lu Xu Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA
Department of Minimally Invasive Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

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Kefeng Yang Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA
Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Andrei Maiseyeu Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Naresh C Bal Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA
KIIT School of Biotechnology, KIIT University, Bhubaneswar, India

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Muthu Periasamy Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Paolo Fadda Nucleic Acid Shared Resource, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA

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Ouliana Ziouzenkova Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA

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glucose for ATP production ( Szkudelski 2007 ). However, in this scenario, LEP appears to indirectly support synthetic processes, notably, lipogenesis ( Buettner et al. 2008 ). Combined, lipogenesis and lipolysis can increase intracellular accumulations

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0289
Volume/Issue:
Volume 239: Issue 3
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Cristina Velasco Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Marta Librán-Pérez Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Cristina Otero-Rodiño Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Marcos A López-Patiño Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Jesús M Míguez Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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José Miguel Cerdá-Reverter Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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José L Soengas Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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( Martins et al . 2013 ). These changes in AMPK and SIRT1 could result in inhibition of de novo lipogenesis and increased fatty acid oxidation, as described in mammals ( Martins et al . 2013 ). The mechanism related to binding of fatty acid to FAT/CD36

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0391
Volume/Issue:
Volume 228: Issue 1
Free access
Chaoyi Zhang Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

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Qianli Zhang Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

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Zhihong Huang Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

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Quan Jiang Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

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enzymes to promote lipogenesis ( Horton et al. 2002 ). In cultured rat hepatocytes, insulin increases SREBP-1c transcriptional level, whereas glucagon decreases SREBP-1c gene expression ( Foretz et al. 1999 ). Recent studies have provided evidence that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0077
Volume/Issue:
Volume 246: Issue 2
Restricted access
Elena Grasselli DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Adriana Voci DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Ilaria Demori DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Canesi DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Rita De Matteis DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Fernando Goglia DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Antonia Lanni DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Gabriella Gallo DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Vergani DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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. Although PPARγ is typically considered a key factor in regulation of lipogenesis, it is a pleiotropic transcription factor that regulates a variety of genes involved in virtually all pathways of lipid metabolism, including local FFA release from circulating

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0288
Volume/Issue:
Volume 212: Issue 2
Free access
Jenny D Y Chow Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of

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Margaret E E Jones Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of

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Katja Prelle Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of

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Evan R Simpson Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of

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Wah Chin Boon Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of

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processing and storing lipids in the body, as it is capable of high rates of β-oxidation, lipogenesis, lipolysis, and transport. Hepatic steatosis is the result of excess TG accumulation in the liver, which may be caused by defects in any of the above

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0462
Volume/Issue:
Volume 210: Issue 3
Free access