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/80, Il6, Mcp1, Il6, NFkB ) ↓ Lipogenesis ( Fasn ) ↓ Fatty acid oxidation ( Pparγ ) ↓ Adipocytes differentiation (C/EBPα) Neyrinck et al . 2011 HF-fed mice Arabinoxylans AX for 4 weeks 4 weeks HF-AX vs HF (qPCR): ↑ Bifidobacterium spp
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Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea
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are major targets of systemic actions of FGF21 in metabolic improvement, although direct repressive effects of FGF21 on gluconeogenesis and lipogenesis in the liver have also been reported ( Zhang et al . 2011 , Kong et al . 2013 ). The importance
Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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4 and Prdm16 , genes involved in thermogenesis, tended to be decreased, as well as genes involved in lipogenesis and adipogenesis such as Pparg, Fas and Acaca ( Fig. 1N ). Therefore, based on our gene expression data with these C57BL/6J mice
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Departments of Medicine and Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA
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important in adipogenesis, lipogenesis, lipolysis, fatty acid metabolism, inflammation and energy balance and regulation. In retroperitoneal VAT, the expression of the PPARα, Scd1 (stearoyl-coenzyme A desaturase 1) , Cepbα, Acaca (acetyl-coenzyme A
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The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia
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The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia
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). Corresponding to the elevated triglyceride content, the enzymes of the lipogenesis pathway ACC ( Fig. 4D ), FAS ( Fig. 4E ) and SCD1 ( Fig. 4F ) were elevated in the livers of mice housed at 29°C, due largely to a significant effect in chow-fed animals. The
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Department of Minimally Invasive Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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KIIT School of Biotechnology, KIIT University, Bhubaneswar, India
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glucose for ATP production ( Szkudelski 2007 ). However, in this scenario, LEP appears to indirectly support synthetic processes, notably, lipogenesis ( Buettner et al. 2008 ). Combined, lipogenesis and lipolysis can increase intracellular accumulations
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( Martins et al . 2013 ). These changes in AMPK and SIRT1 could result in inhibition of de novo lipogenesis and increased fatty acid oxidation, as described in mammals ( Martins et al . 2013 ). The mechanism related to binding of fatty acid to FAT/CD36
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enzymes to promote lipogenesis ( Horton et al. 2002 ). In cultured rat hepatocytes, insulin increases SREBP-1c transcriptional level, whereas glucagon decreases SREBP-1c gene expression ( Foretz et al. 1999 ). Recent studies have provided evidence that
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DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
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DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
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. Although PPARγ is typically considered a key factor in regulation of lipogenesis, it is a pleiotropic transcription factor that regulates a variety of genes involved in virtually all pathways of lipid metabolism, including local FFA release from circulating
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
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Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
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Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
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Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
Prince Henry's Institute, Anatomy and Cell Biology, Biochemistry and Molecular Biology, Bayer Pharma AG, Florey Neuroscience Institutes, Clayton, Victoria 3168, Australia Departments of
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processing and storing lipids in the body, as it is capable of high rates of β-oxidation, lipogenesis, lipolysis, and transport. Hepatic steatosis is the result of excess TG accumulation in the liver, which may be caused by defects in any of the above