Introduction Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptors that were initially identified as targets of compounds that increase peroxisome proliferation. Three PPAR genes have been identified – NR1C1, NR1
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Samuel M Lee, Jose Muratalla, Marta Sierra-Cruz, and Jose Cordoba-Chacon
Dan Li, Yan Ji, Chunlan Zhao, Yapeng Yao, Anlan Yang, Honghong Jin, Yang Chen, Mingjun San, Jing Zhang, Mingjiao Zhang, Luqing Zhang, Xuechao Feng, and Yaowu Zheng
care facility of Transgenic Research Center of Northeast Normal University. References Ali S Ali S 1998 Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways . Journal of Biological
Juan Bernal
during brain development. These include iodine deficiency, maternal and fetal hypothyroidism, maternal hypothyroxinemia, prematurity, nuclear T 3 receptor mutations (TR) and mutations of the monocarboxylate 8 transporter (MCT8) gene SLC16A2 . These
Haifan Zhang, Tim McElrath, Wei Tong, and Jeffrey W Pollard
. Korach KS 1994 Insights from the study of animals lacking functional estrogen receptor. Science 266 1524 –1527. Lai MD , Lee LR, Cheng KS & Wing LY 2000 Expression of proliferating cell nuclear antigen in luminal
Ángel Enrique Céspedes Rubio, Maria José Pérez-Alvarez, Catalina Lapuente Chala, and Francisco Wandosell
), which are classified into two main groups. The first, known as the ‘classical’ ERs (ERα and ERβ), belong to the nuclear receptor superfamily and act as nuclear transcription factors ( Hewitt et al . 2010 ). The second group, ‘non-classical’ ERs (G
Alena Nareika, Yeong-Bin Im, Bryan A Game, Elizabeth H Slate, John J Sanders, Steven D London, Maria F Lopes-Virella, and Yan Huang
activities of AP-1, nuclear factor κB (NFκB), and early growth response 1, which play an important role in the transcriptional activation of genes involved in inflammation. In addition to the effect of high glucose on gene expression as described above, our
Hyunju Chung, Sanghee Seo, Minho Moon, and Seungjoon Park
unique peptide esterified with octanoic acid on Ser 3 ( Kojima & Kangawa 2005 ). This acylation is essential for the binding of ghrelin to the growth hormone (GH) secretagog receptor 1a (GHS-R1a; Kojima et al . 1999 ). AG stimulates GH release and
R. N. KURL and N. M. BORTHWICK
SUMMARY
The concentrations of progesterone receptors in uterine cytoplasm and nuclei were measured during the oestrous cycle of the rat. The concentration of cytoplasmic progesterone receptors was highest at pro-oestrus and declined at oestrus to reach lowest levels at metoestrus before rising at dioestrus. Similar changes were observed in the concentration of nuclear progesterone receptors, the highest levels being present at pro-oestrus and dioestrus. In addition, both activities A and B of RNA polymerase mirrored these alterations in nuclear receptor levels.
J Kwakkel, W M Wiersinga, and A Boelen
thyroid hormone in mice with complete deficiency of thyroid hormone receptor α. PNAS 98 349 –354. McDonald DR , Janssen R & Geha R 2006 Lessons learned from molecular defects in nuclear factor κB dependent
Sharon Maor, Doris Mayer, Ronit I Yarden, Adrian V Lee, Rive Sarfstein, Haim Werner, and Moshe Z Papa
Introduction The insulin-like growth factors, IGF-I and IGF-II, are a family of mitogenic polypeptides with important roles in growth and differentiation. The biological actions of the IGFs are mediated by the IGF-I receptor (IGF
