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A Iida-Klein Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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S Shou Lu Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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R Kapadia Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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M Burkhart Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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A Moreno Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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D W Dempster Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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R Lindsay Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA

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, and carefully monitored for any signs of stress, bleeding, pain or abnormal behavior. Two independent experiments were performed (Table 1 ). All animals were randomly divided into groups 2 days prior to implantation of the pumps. Experiment 1

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M Asfari Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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S Berta Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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S Coffy Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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M Kergoat Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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C Charon Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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A Audet Merck-Santé, Centre de Recherche, 4 Avenue du Président François Mitterand, 91385 Chilly-Mazarin, Cedex, Paris, France

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reduce the eventual pain. Each transplanted rat also received a dose of 100 mg antibiotic i.m. (Clamoxyl; Smithkline Beecham). All experiments conformed to the relevant guidelines of the French Ministry of Agriculture for scientific

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María E Trujillo-Ortega Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Daniel Mota-Rojas Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Rafael Hernández-González Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Elvia Yadira Velázquez-Armenta Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Alejandro A Nava-Ocampo Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Ramiro Ramírez-Necoechea Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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Marcelino Becerril-Herrera Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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María Alonso-Spilsbury Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México
Department of Animal Production and Agriculture, Research Area: Ecodesarrollo de la Producción Animal, School of Veterinary Medicine, Universidad Autónoma Metropolitana-Xochimilco, México
Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
EIAH-Benemérita Universidad Autónoma de Puebla, San Juan Acateno, Teziutlan, Puebla, México

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. 2003 ). It was assumed that procedures would add mild pain, suffering and distress to that expected during standard attention in the labor process. Cell phones, televisions or other sources of noise were not allowed in the production and delivery areas

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Laurent Givalois Molecular Mechanisms in Neurodegenerative Dementia Laboratory, U710 Inserm, University of Montpellier 2, EPHE, Place E Bataillon, 34095 Montpellier, France

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Gaëlle Naert Molecular Mechanisms in Neurodegenerative Dementia Laboratory, U710 Inserm, University of Montpellier 2, EPHE, Place E Bataillon, 34095 Montpellier, France

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Lucia Tapia-Arancibia Molecular Mechanisms in Neurodegenerative Dementia Laboratory, U710 Inserm, University of Montpellier 2, EPHE, Place E Bataillon, 34095 Montpellier, France

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Sandor Arancibia Molecular Mechanisms in Neurodegenerative Dementia Laboratory, U710 Inserm, University of Montpellier 2, EPHE, Place E Bataillon, 34095 Montpellier, France

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Guide for the Care and Use of Laboratory Animals, NIH Publication No. 85–23 1985). All protocols were approved by the Animal Welfare Committee at the University of Montpellier II, which aims to minimize the number of animals used, and potential pain and

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Martin Haluzík Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Helena Kratochvílová Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Denisa Haluzíková Department of Sports Medicine, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Miloš Mráz Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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randomized and 10 observational studies a DJBL implantation was accompanied by excess weight loss of 5.1 kg and a decrease of HbA1c of 0.9% and fasting plasma glucose by 3.7mmol/L ( Rohde et al . 2016 ). Adverse events consisted mainly of abdominal pain

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Roger Guillemin Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA

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somatostatin or one of the analogs has been reported to reduce synovitis and inflammation in patients with rheumatoid arthritis ( Coari et al. 1995 ). It also reduces the concomitant pain possibly because, in a new twist and as recently demonstrated

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Cátia F Gonçalves Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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Qing-Jun Meng Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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circadian variation of pain ( Huskisson et al. 1970 , Kowanko et al. 1981 , Levi et al. 1985 ). More recently, it was demonstrated that timing teriparatide dosing affected the circadian rhythms of bone resorption markers in postmenopausal

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Alessandra Fierabracci
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Maria Ausiliatrice Puglisi
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Laura Giuliani
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Stefano Mattarocci Autoimmunity and Organ Regeneration Laboratory, Istituto di Neurobiologia e Medicina Molecolare-CNR, Department of Surgery, Ospedale Pediatrico Bambino Gesù Scientific Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy

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Marco Gallinella-Muzi Autoimmunity and Organ Regeneration Laboratory, Istituto di Neurobiologia e Medicina Molecolare-CNR, Department of Surgery, Ospedale Pediatrico Bambino Gesù Scientific Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy

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2002 ). It is relevant to underline the expression at mRNA level of pluripotency markers Oct-4 and Nanog ( Pain et al . 2005 ) in all the lines examined. A further characterization of the thyrospheres was the analysis of the telomere length and of the

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S R Davis Department of Medicine (CECS), Monash University, Victoria, Australia
The Jean Hailes Foundation, 173 Carinish Road, Clayton, Victoria, Australia
Department of Biochemistry, Monash University, Clayton, Victoria, Australia

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I Dinatale Department of Medicine (CECS), Monash University, Victoria, Australia
The Jean Hailes Foundation, 173 Carinish Road, Clayton, Victoria, Australia
Department of Biochemistry, Monash University, Clayton, Victoria, Australia

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L Rivera-Woll Department of Medicine (CECS), Monash University, Victoria, Australia
The Jean Hailes Foundation, 173 Carinish Road, Clayton, Victoria, Australia
Department of Biochemistry, Monash University, Clayton, Victoria, Australia

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S Davison Department of Medicine (CECS), Monash University, Victoria, Australia
The Jean Hailes Foundation, 173 Carinish Road, Clayton, Victoria, Australia
Department of Biochemistry, Monash University, Clayton, Victoria, Australia

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( Goldzieher 2000 ). The purpose of the menstrual cycle, particularly the bleeding, intrigued physicians. As a consequence of the pain, smell and occasionally putrefying appearance, it was believed that the menses were a form of detoxification of poisons from

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Sara S Ellingwood Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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Alan Cheng Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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al . 2015 a ), the most common GSD affecting the muscle. Although symptoms may occur early in life, a diagnosis is usually made in adulthood. Individuals with GSD type V show exercise intolerance, muscle weakness, cramping as well as pain

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