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transcription factor were significantly increased in the octreotide-treated rats. As CYP2C11 and IGF1 expression require the activation (i.e. phosphorylation) and nuclear translocation of STAT5B ( Waxman & O'Connor 2006 , Thangavel & Shapiro 2007 ), we
Pharmacology Research 4, Novo Nordisk A/S, Novo Nordisk Park F6.2.13, DK 2760 Måløv, Denmark
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
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Pharmacology Research 4, Novo Nordisk A/S, Novo Nordisk Park F6.2.13, DK 2760 Måløv, Denmark
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
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Pharmacology Research 4, Novo Nordisk A/S, Novo Nordisk Park F6.2.13, DK 2760 Måløv, Denmark
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
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Pharmacology Research 4, Novo Nordisk A/S, Novo Nordisk Park F6.2.13, DK 2760 Måløv, Denmark
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
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Pharmacology Research 4, Novo Nordisk A/S, Novo Nordisk Park F6.2.13, DK 2760 Måløv, Denmark
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
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hGH and cytokines on the induction of SOCS-3 mRNA expression after extended exposure. Effects of hGH and cytokines on activation of the transcription factors NFκB, STAT1 and STAT5 To determine whether activation of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
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London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
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100 kb of the STC2 gene ( Lin et al . 2007 ). Therefore, it seems likely that for E 2 regulation of the STC2 gene, other transcription factors may be mediating the effect as has been documented for the Sp1, AP-1 and nuclear factor-κB ( Chambliss
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by first binding to the GH receptor (GHR) and then triggering signal transduction cascades resulting in physiological responses ( Argetsinger & Carter-Su 1996 ). Although several transcription factors were believed to be involved in GH signaling
Laboratory Animal Center, Nantong University, Nantong, Jiangsu, China
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School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, Jiangsu, China
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Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China
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Introduction The obesity epidemic continues to rise as a global health challenge. Obesity is a major risk factor for high blood pressure, hyperlipidemia, diabetes, heart disease, cancers, etc. ( Ng et al. 2014 , Ogden et al. 2014 ). The
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estrogen receptors (ERs), ERα and ERβ ( Dahlman-Wright et al . 2006 ). ERs belong to the nuclear receptor family of ligand-activated transcription factors, and modulate the expression of target genes by binding either to classic estrogen response
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-binding protein ( bteb ) in the brain. The bteb gene encodes a zinc-fingered transcription factor that binds GC-box domains to regulate TH-mediated gene transcription. Previously, bteb has been shown to be TH regulated in the brain of mice ( Denver et al
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-activating transcription factor 4 (ATF4) (sc200) antibodies were obtained from Santa Cruz Technology. Anti-BAX (B3428) and anti-β-actin (A5316) antibodies were obtained from Sigma; anti-AKT1 (05-796) was obtained from Upstate Biotechnology (Waltham, MA, USA); and anti
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
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Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
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Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
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Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
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Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
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superfamily of ligand activated transcription factors ( Robinson-Rechavi et al . 2003 ). PPARs, particularly PPARα and γ, are regulators of lipid metabolism because they act as lipid sensors. Therefore, PPAR ligands represent important pharmaceutical agents
Department of Endocrinology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
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interstitial and perivascular fibrosis, ventricular hypertrophy, as well as diastolic and systolic dysfunction, all occurring in the absence of coronary artery disease and hypertension ( Bugger & Abel 2014 ). The underlying factors driving the development of