transcription factor were significantly increased in the octreotide-treated rats. As CYP2C11 and IGF1 expression require the activation (i.e. phosphorylation) and nuclear translocation of STAT5B ( Waxman & O'Connor 2006 , Thangavel & Shapiro 2007 ), we
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Rajat Kumar Das, Sarmistha Banerjee, and Bernard H Shapiro
Jay H Lo, Pinwen Peter Chiou, C M Lin, and Thomas T Chen
by first binding to the GH receptor (GHR) and then triggering signal transduction cascades resulting in physiological responses ( Argetsinger & Carter-Su 1996 ). Although several transcription factors were believed to be involved in GH signaling
Sanda Raulic, Yudith Ramos-Valdes, and Gabriel E DiMattia
100 kb of the STC2 gene ( Lin et al . 2007 ). Therefore, it seems likely that for E 2 regulation of the STC2 gene, other transcription factors may be mediating the effect as has been documented for the Sp1, AP-1 and nuclear factor-κB ( Chambliss
Sean C Lema, Jon T Dickey, Irvin R Schultz, and Penny Swanson
-binding protein ( bteb ) in the brain. The bteb gene encodes a zinc-fingered transcription factor that binds GC-box domains to regulate TH-mediated gene transcription. Previously, bteb has been shown to be TH regulated in the brain of mice ( Denver et al
Qinghua Wang, Jing Tang, Shujun Jiang, Zan Huang, Anying Song, Siyuan Hou, Xiang Gao, and Hai-Bin Ruan
Introduction The obesity epidemic continues to rise as a global health challenge. Obesity is a major risk factor for high blood pressure, hyperlipidemia, diabetes, heart disease, cancers, etc. ( Ng et al. 2014 , Ogden et al. 2014 ). The
José Edgar Nicoletti-Carvalho, Tatiane C Araújo Nogueira, Renata Gorjão, Carla Rodrigues Bromati, Tatiana S Yamanaka, Antonio Carlos Boschero, Licio Augusto Velloso, Rui Curi, Gabriel Forato Anhê, and Silvana Bordin
-activating transcription factor 4 (ATF4) (sc200) antibodies were obtained from Santa Cruz Technology. Anti-BAX (B3428) and anti-β-actin (A5316) antibodies were obtained from Sigma; anti-AKT1 (05-796) was obtained from Upstate Biotechnology (Waltham, MA, USA); and anti
Shaodong Guo
) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin
L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright, and A Khan
estrogen receptors (ERs), ERα and ERβ ( Dahlman-Wright et al . 2006 ). ERs belong to the nuclear receptor family of ligand-activated transcription factors, and modulate the expression of target genes by binding either to classic estrogen response
A Fratticci, F A Grieco, C Spilioti, F Giangaspero, L Ventura, V Esposito, M Piccirilli, A Santoro, A Gulino, G Cantore, E Alesse, and M L Jaffrain-Rea
Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and
Wu Luo, Lan Huang, Jingying Wang, Fei Zhuang, Zheng Xu, Haimin Yin, Yuanyuan Qian, Guang Liang, Chao Zheng, and Yi Wang
interstitial and perivascular fibrosis, ventricular hypertrophy, as well as diastolic and systolic dysfunction, all occurring in the absence of coronary artery disease and hypertension ( Bugger & Abel 2014 ). The underlying factors driving the development of
