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Sanda Raulic London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Yudith Ramos-Valdes London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Gabriel E DiMattia London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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hormonal treatment, they were washed twice with 1× PBS and cultured in an oestrogen-depleted medium: phenol red-free DMEM-F12 medium with 10% charcoal-stripped FBS (Wisent) and 50 μg/ml penicillin–streptomycin, for 24 h. For gene regulation studies in MCF-7

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0043
Volume/Issue:
Volume 197: Issue 3
Free access
Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Peter Aldiss Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Neele Dellschaft Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Hernan P Fainberg Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Harold Sacks VA Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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et al . 2018 ). Dynamic changes in gene regulation with age are rarely examined but do enable the identification of important regulatory relationships. These will have crucial depot-specific roles to enable differentiation and the adaptation necessary

Article Type:
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DOI:
https://doi.org/10.1530/JOE-18-0084
Volume/Issue:
Volume 238: Issue 1
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Juan Sun Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Liqun Mao Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Hongyan Yang Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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Decheng Ren Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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412 179 – 190 . ( https://doi.org/10.1042/BJ20080281 ) 10.1042/BJ20080281 Iype T Francis J Garmey JC Schisler JC Nesher R Weir GC Becker TC Newgard CB Griffen SC Mirmira RG 2005 Mechanism of insulin gene regulation by the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0015
Volume/Issue:
Volume 238: Issue 2
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Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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activity) and that results in a male and female differential endocrine susceptibility and gene regulation, particularly in sex steroid-responsive genes. The relevance of oestrogen programming mechanisms within the mammalian foetus and perinatal time period

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DOI:
https://doi.org/10.1530/JOE-18-0003
Volume/Issue:
Volume 238: Issue 3
Open access
Viktorija Gustaityte Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Martina Winkler Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Ines Stölting Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Walter Raasch Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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FM Johren O Raasch W 2012 Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARgamma target gene regulation . Endocrinology 153 1103 – 1115 . ( https://doi.org/10.1210/en.2011-0183 ) 22253423 10

Article Type:
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DOI:
https://doi.org/10.1530/JOE-18-0477
Volume/Issue:
Volume 240: Issue 1
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María Andrea Camilletti Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Alejandra Abeledo-Machado Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Jimena Ferraris Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Pablo A Pérez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Erika Y Faraoni Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Daniel Pisera Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Silvina Gutierrez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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.09.001 ) 28969926 10.1016/j.tins.2017.09.001 Mitchner NA Garlick C Ben Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland . Endocrinology 139 3976 – 3983 . ( https://doi.org/10

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DOI:
https://doi.org/10.1530/JOE-18-0402
Volume/Issue:
Volume 240: Issue 2
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Liliana del V Sosa Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Juan P Petiti Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Florencia Picech Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Sabrina Chumpen Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Cordoba, Argentina

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Juan P Nicola Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIBICI-CONICET, Cordoba, Argentina

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Pablo Perez Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Ana De Paul Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Javier Valdez-Taubas Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Cordoba, Argentina

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Silvina Gutierrez Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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Alicia I Torres Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina

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signaling . Endocrinology 154 4293 – 4304 . ( https://doi.org/10.1210/en.2013-1172 ) 24008343 10.1210/en.2013-1172 Mitchner NA Garlick C Ben-Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0418
Volume/Issue:
Volume 240: Issue 2
Free access
Rui Song Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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Xiang-Qun Hu Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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Lubo Zhang Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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of heart development and disease by glucocorticoids. DNA methylation DNA methylation catalyzed by DNA methyltransferases is an epigenetic mechanism for gene regulation ( Yang et al. 2010 ). Dynamic DNA methylation is vital for mammalian heart

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0672
Volume/Issue:
Volume 242: Issue 1
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Maria Esteban-Lopez Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Miami, Florida, USA

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Alexander I Agoulnik Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Miami, Florida, USA
Biomolecular Science Institute, Florida International University, Miami, Florida, USA

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177 1947 – 1951 . ( https://doi.org/10.1016/j.juro.2007.01.002 ) Feng S Bogatcheva NV Truong A Korchin B Bishop CE Klonisch T Agoulnik IU Agoulnik AI 2007 Developmental expression and gene regulation of insulin-like 3 receptor

Article Type:
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DOI:
https://doi.org/10.1530/JOE-20-0168
Volume/Issue:
Volume 247: Issue 1
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Hsiu-Chi Lee Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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Shaw-Jenq Tsai Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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of gene regulation. It would be interesting to investigate whether hypoxia also regulates RNA or histone modification to modulate gene expression epigenetically in endometriosis. Figure 3 Hypoxia is involved in pathological processes of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0653
Volume/Issue:
Volume 234: Issue 1
Free access