Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 111 - 120 of 1,205 items for :

  • "transcription factor" x
  • Refine by access: All content x
Clear All
Mi-Hyun Kim
Search for other papers by Mi-Hyun Kim in
Google Scholar
PubMed Close
,
Jae-Hwan Jee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

Search for other papers by Jae-Hwan Jee in
Google Scholar
PubMed Close
,
Sunyoung Park
Search for other papers by Sunyoung Park in
Google Scholar
PubMed Close
,
Myung-Shik Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

Search for other papers by Myung-Shik Lee in
Google Scholar
PubMed Close
,
Kwang-Won Kim Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

Search for other papers by Kwang-Won Kim in
Google Scholar
PubMed Close
, and
Moon-Kyu Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

Search for other papers by Moon-Kyu Lee in
Google Scholar
PubMed Close

transcription factor 7-like 2 (TCF7L2), which has its binding site in the G2 enhancer element of proglucagon ( G lu ), a precursor of GLP1 ( Akiyama 2000 ). Insulin enhances GLP1 production via inhibition of glycogen synthase kinase (GSK)-3β

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0381
Volume/Issue:
Volume 220: Issue 2
Free access
C D Simmons
Search for other papers by C D Simmons in
Google Scholar
PubMed Close
,
J M P Pabona
Search for other papers by J M P Pabona in
Google Scholar
PubMed Close
,
Z Zeng
Search for other papers by Z Zeng in
Google Scholar
PubMed Close
,
M C Velarde
Search for other papers by M C Velarde in
Google Scholar
PubMed Close
,
D Gaddy
Search for other papers by D Gaddy in
Google Scholar
PubMed Close
,
F A Simmen
Search for other papers by F A Simmen in
Google Scholar
PubMed Close
, and
R C M Simmen Department of Physiology and Biophysics, Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, Arkansas 72202, USA

Search for other papers by R C M Simmen in
Google Scholar
PubMed Close

precise mechanisms and participating molecules remain poorly understood. Krüppel-like factor (KLF) 9, a member of the Sp/KLF family of transcription factors ( Suske et al . 2005 ), is a 244-amino acid protein characterized by three C-terminal zinc finger

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0474
Volume/Issue:
Volume 205: Issue 2
Free access
José Edgar Nicoletti-Carvalho
Search for other papers by José Edgar Nicoletti-Carvalho in
Google Scholar
PubMed Close
,
Tatiane C Araújo Nogueira
Search for other papers by Tatiane C Araújo Nogueira in
Google Scholar
PubMed Close
,
Renata Gorjão Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

Search for other papers by Renata Gorjão in
Google Scholar
PubMed Close
,
Carla Rodrigues Bromati
Search for other papers by Carla Rodrigues Bromati in
Google Scholar
PubMed Close
,
Tatiana S Yamanaka
Search for other papers by Tatiana S Yamanaka in
Google Scholar
PubMed Close
,
Antonio Carlos Boschero Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

Search for other papers by Antonio Carlos Boschero in
Google Scholar
PubMed Close
,
Licio Augusto Velloso Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

Search for other papers by Licio Augusto Velloso in
Google Scholar
PubMed Close
,
Rui Curi
Search for other papers by Rui Curi in
Google Scholar
PubMed Close
,
Gabriel Forato Anhê Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

Search for other papers by Gabriel Forato Anhê in
Google Scholar
PubMed Close
, and
Silvana Bordin
Search for other papers by Silvana Bordin in
Google Scholar
PubMed Close

-activating transcription factor 4 (ATF4) (sc200) antibodies were obtained from Santa Cruz Technology. Anti-BAX (B3428) and anti-β-actin (A5316) antibodies were obtained from Sigma; anti-AKT1 (05-796) was obtained from Upstate Biotechnology (Waltham, MA, USA); and anti

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0356
Volume/Issue:
Volume 206: Issue 2
Free access
Sami Ayari Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Sami Ayari in
Google Scholar
PubMed Close
,
Eva Gil-Iturbe Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Eva Gil-Iturbe in
Google Scholar
PubMed Close
,
Léa le Gléau Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Léa le Gléau in
Google Scholar
PubMed Close
,
Céline Osinski Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Céline Osinski in
Google Scholar
PubMed Close
,
Nathalie Kapel AP-HP Hôpital Pitié-Salpêtrière-Charles Foix, Functional Coprology Department, Paris, France

Search for other papers by Nathalie Kapel in
Google Scholar
PubMed Close
,
Hedi Antoine Soula Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Hedi Antoine Soula in
Google Scholar
PubMed Close
,
Armelle Leturque Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Armelle Leturque in
Google Scholar
PubMed Close
,
Fabrizio Andreelli Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France
AP-HP Hôpital Pitié-Salpêtrière-Charles Foix, Nutrition Department, Paris, France
AP-HP Hôpital Pitié-Salpêtrière-Charles Foix, Diabetology-Metabolism Department, Paris, France

Search for other papers by Fabrizio Andreelli in
Google Scholar
PubMed Close
,
Karine Clément Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France
AP-HP Hôpital Pitié-Salpêtrière-Charles Foix, Nutrition Department, Paris, France

Search for other papers by Karine Clément in
Google Scholar
PubMed Close
,
Patricia Serradas Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Patricia Serradas in
Google Scholar
PubMed Close
, and
Agnès Ribeiro Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France

Search for other papers by Agnès Ribeiro in
Google Scholar
PubMed Close

in vivo and in vitro have shown that HNF-4α plays pleiotropic roles in liver functions and is a central transcription factor at the crossroads between epithelial morphogenesis and functions ( Battle et al. 2006 , Ribeiro et al. 2007 , Hwang

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0092
Volume/Issue:
Volume 252: Issue 1
Restricted access
C D Soontjens
Search for other papers by C D Soontjens in
Google Scholar
PubMed Close
,
J J Rafter
Search for other papers by J J Rafter in
Google Scholar
PubMed Close
, and
J-Å Gustafsson
Search for other papers by J-Å Gustafsson in
Google Scholar
PubMed Close

Introduction

Nuclear receptors

The cell's long-term response to environmental stimuli is associated with changes in cellular proliferation, differentiation and metabolism mediated by the modification of the protein content of a cell via differential gene expression. Transcription factors that regulate the activity of specific genes receive such stimuli in different ways. Peptide hormones, growth factors and neurotransmitters bind and activate cell surface receptors, initiating a cascade of intracellular signals by a complex system of secondary messengers that leads to the activation of transcription factors. Other transcription factors that are responsive to steroid and thyroid hormones, retinoids and other signalling molecules belong to the distinct class of nuclear receptors present in the cytoplasm or nucleus. Direct and high affinity binding of a specific signalling molecule or ligand activates the nuclear receptors to exert control on the rate of transcription of target genes via interaction with specific DNA sequences

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.150S241
Volume/Issue:
Volume 150: Issue 3_Suppl
Restricted access
Stefanie Ruhs Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

Search for other papers by Stefanie Ruhs in
Google Scholar
PubMed Close
,
Alexander Nolze Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

Search for other papers by Alexander Nolze in
Google Scholar
PubMed Close
,
Ralf Hübschmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

Search for other papers by Ralf Hübschmann in
Google Scholar
PubMed Close
, and
Claudia Grossmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

Search for other papers by Claudia Grossmann in
Google Scholar
PubMed Close

( Fig. 1 ). Figure 1 Aldosterone/MR signaling. Aldosterone (aldo) has several mechanisms of action. (1) It can bind to cytosolic MR and initiate translocation of MR into the nucleus, where the MR homodimerizes and acts as a transcription factor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0659
Volume/Issue:
Volume 234: Issue 1
Free access
Susan M Soto Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Susan M Soto in
Google Scholar
PubMed Close
,
Amy C Blake Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Amy C Blake in
Google Scholar
PubMed Close
,
Stephanie R Wesolowski Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Stephanie R Wesolowski in
Google Scholar
PubMed Close
,
Paul J Rozance Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Paul J Rozance in
Google Scholar
PubMed Close
,
Kristen B Barthel Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, BioFrontiers Institute, Boulder, Colorado, USA

Search for other papers by Kristen B Barthel in
Google Scholar
PubMed Close
,
Bifeng Gao Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

Search for other papers by Bifeng Gao in
Google Scholar
PubMed Close
,
Byron Hetrick Department of Human Physiology, University of Oregon, Eugene, Oregon, USA

Search for other papers by Byron Hetrick in
Google Scholar
PubMed Close
,
Carrie E McCurdy Department of Human Physiology, University of Oregon, Eugene, Oregon, USA

Search for other papers by Carrie E McCurdy in
Google Scholar
PubMed Close
,
Natalia G Garza Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Natalia G Garza in
Google Scholar
PubMed Close
,
William W Hay Jr Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by William W Hay Jr in
Google Scholar
PubMed Close
,
Leslie A Leinwand Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, BioFrontiers Institute, Boulder, Colorado, USA

Search for other papers by Leslie A Leinwand in
Google Scholar
PubMed Close
,
Jacob E Friedman Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Jacob E Friedman in
Google Scholar
PubMed Close
, and
Laura D Brown Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

Search for other papers by Laura D Brown in
Google Scholar
PubMed Close

protein 7 (PAX7) denotes a myoblast that has not terminally differentiated and has the capacity to enter the cell cycle and proliferate ( Relaix et al . 2005 ). MRFs are a set of transcription factors, including MYF5 , MYOD , MYF6 and MYOG , that are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0123
Volume/Issue:
Volume 232: Issue 3
Free access
A Alidibbiat
Search for other papers by A Alidibbiat in
Google Scholar
PubMed Close
,
C E Marriott Diabetes Research Group, School of Pharmacy and Biomolecular Sciences, Department of Diabetes, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Search for other papers by C E Marriott in
Google Scholar
PubMed Close
,
K T Scougall
Search for other papers by K T Scougall in
Google Scholar
PubMed Close
,
S C Campbell
Search for other papers by S C Campbell in
Google Scholar
PubMed Close
,
G C Huang Diabetes Research Group, School of Pharmacy and Biomolecular Sciences, Department of Diabetes, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Search for other papers by G C Huang in
Google Scholar
PubMed Close
,
W M Macfarlane Diabetes Research Group, School of Pharmacy and Biomolecular Sciences, Department of Diabetes, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Search for other papers by W M Macfarlane in
Google Scholar
PubMed Close
, and
J A M Shaw
Search for other papers by J A M Shaw in
Google Scholar
PubMed Close

 s at 58 °C, 45 s at 72 °C; 5 min at 72 °C). PCR cycle number was 35 for all primer pairs with the exception of Isl1 (29 cycles) and forkhead box transcription factor a2 (Foxa2; 40 cycles). PCR products were separated and visualised on 1% agarose gels

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0397
Volume/Issue:
Volume 196: Issue 1
Free access
Melody L Allensworth-James Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Melody L Allensworth-James in
Google Scholar
PubMed Close
,
Angela Odle Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Angela Odle in
Google Scholar
PubMed Close
,
Anessa Haney Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Anessa Haney in
Google Scholar
PubMed Close
,
Melanie MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Melanie MacNicol in
Google Scholar
PubMed Close
,
Angus MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Angus MacNicol in
Google Scholar
PubMed Close
, and
Gwen Childs Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Gwen Childs in
Google Scholar
PubMed Close

and proliferation of the individual endocrine cell populations ( Rizzoti 2015 ). The earliest exclusive pituitary marker is PROP1 , a paired homeodomain transcription factor, which is expressed at embryonic day 10 (E10) in the mouse. SOX2- expressing

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0238
Volume/Issue:
Volume 238: Issue 3
Free access
Manon M Roustit
Search for other papers by Manon M Roustit in
Google Scholar
PubMed Close
,
Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Joan M Vaughan in
Google Scholar
PubMed Close
,
Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed Close
, and
Mark E Cleasby
Search for other papers by Mark E Cleasby in
Google Scholar
PubMed Close

transcription factors in macrophages ( Tsatsanis et al . 2006 ). These data contrast with the reduced IRS1 and AKT phosphorylation observed in the transgenic mice ( Jamieson et al . 2011 ), which may have been the result of the reduced circulating insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0181
Volume/Issue:
Volume 223: Issue 2
Open access