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Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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tissues/cells are under ‘normal’ hypoxic condition (examples like pericentral hepatocytes, bone marrow, Sertoli cells of testis, granulosa and germ cells of ovarian follicles and islet cells of pancreas). These normal hypoxic tissues/cells are adaptive to
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& Crafts 1968 , Peschle et al. 1972 , Golde et al. 1977 ). GH directly stimulated the proliferation of erythroid progenitor cells in vitro ( Golde et al. 1977 ). Erythropoiesis was stimulated in rat bone marrow perfused with GH ( Meineke & Crafts
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decrease in serum testosterone concentration in middle to older aged men is associated with a reduction serum SHBG with mid-normal serum LH and FSH and is characterised by an accumulation of visceral adipose tissue associated with insulin resistance
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
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et al. 2021 ). Brown adipose tissue (BAT) dissipates energy in the form of heat by highly expressed uncoupling protein 1 (UCP1) protein to uncouple the mitochondrial proton gradient, which is important for thermogenesis and energy balance in mammals
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Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA
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Department of Cell and Microbiology, Weill Cornell Medical College, New York, New York, USA
Department of Genetics, The University of Texas Anderson Cancer Center, Houston, Texas, USA
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Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas, USA
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Department of Cell and Microbiology, Weill Cornell Medical College, New York, New York, USA
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. ( https://doi.org/10.4161/isl.20516 ) McCabe LR Irwin R Tekalur A Evans C Schepper JD Parameswaran N & Ciancio M 2019 Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice . Bone 118 20 – 31
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pathway in human conditions of imbalance between osteogenesis and adipogenesis, such as the increase in marrow adipose tissue and decrease in bone seen in osteoporosis ( Meunier et al . 1971 , Verma et al . 2002 , Nuttall & Gimble 2004 ). Furthermore
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
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Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
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. Transporters are also involved in the transport of T3 out of the cell. Not all transporters are expressed in all tissues. MCT8 is expressed in neurons, the pituitary, liver, kidney, and adipose tissue, while MCT10 is expressed in the kidney, liver, muscle
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I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
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I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
Gynecologic Endocrinology Research Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
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reduced visceral adiposity ( Maneschi et al. 2013 ). These beneficial effects seem to occur partially by enhancing energy expenditure through activation of thermogenesis in brown adipose tissue (BAT) and in muscle ( Thomas et al. 2009 ). Activation of
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cervical dislocation. Inguinal, retroperitoneal and epididymal white adipose tissue (WAT) and interscapular brown adipose tissue (isBAT) fat depots and liver were excised, weighed, snap frozen and stored at −70°C for subsequent histological analysis (see
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. 2015 , Zhang et al. 2018 ). In our previous studies, we have found that miR-188 promotes the adipogenic differentiation of bone marrow mesenchymal stem cells and fat accumulation in bone ( Li et al. 2015 ), followed with the finding that adipose