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murine embryonic and postnatal mechanisms of IGFBP-4 without specifically looking at sexual dimorphism ( Ning et al . 2006 , 2008 ). In contrast, we examined pubertal and adult skeletal maintenance in C57BL/6J mice by phenotyping mice with a germline
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the first time described the identification of sexual dimorphisms in metabolic and genetic biomarkers. Until then, most studies that associated metabolite concentrations and ratios of measured metabolites with defined phenotypes had not considered
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Chowen JA Zeitler P Clifton DK Steiner RA 1991 Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development . Endocrinology 128 2369 – 2375
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male mice have 16% more spinal motor neurons than their WT sisters, with this sexual dimorphism being absent in AMH −/− and AMHR2 −/− mice ( Wang et al . 2009 b ). AMH + /− mice exhibit a male bias which is half that of their WT brothers ( Wang et
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. Laughlin GA & Barrett-Connor E 2000 Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. Journal of Clinical Endocrinology and Metabolism 85 3561 –3568. Laumann EO
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Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zürich, Switzerland
School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
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Beuschlein F Wolfrum C , 2022 Sexual dimorphism in COVID-19: potential clinical and public health implications . Lancet. Diabetes and Endocrinology 10 221 – 230 . ( https://doi.org/10.1016/S2213-8587(2100346-6 ) Bornstein SR Cozma D Kamel M
Department of Biosciences, Nottingham Trent University, Nottingham, UK
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NEXUS, Discovery Way, University of Leeds, Leeds, UK
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Department of Biosciences, Nottingham Trent University, Nottingham, UK
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in male mice. As such, we can discount the possibility of sexual dimorphism with respect to our findings. Indeed, there is evidence of sexually dimorphic expression of hepatic 11β-HSD1 in rats, underpinned by sex-specific changes in growth hormone
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& Leinwand 2009 ). The incidence of CVD in women increases after menopause; when comparing men and women over 65 years of age, this sexual dimorphism disappears and mortality is higher in postmenopausal women compared with age-matched men ( Bhupathy et al
Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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that cross-sex hormones affect psychological variables of aggression, mood, sexual motivation and sex-related cognitive functions, such as verbal fluency and visuospatial functions ( Van Goozen et al. 1995 , Slabbekoorn et al. 1999 ). Studies of
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2010 The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons . European Journal of Neuroscience 31 1984 – 1998 . ( doi:10.1111/j.1460-9568.2010.07239.x