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) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin
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corticotropin-releasing factor, vasopressin and interleukin-6 gene transcription in hypothalamic 4B cells . Journal of Endocrinology 195 199 – 211 . Karalis K Muglia LJ Bae D Hilderbrand JA 1997 CRH and the immune system . Journal of
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy
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Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and
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( Fig. 1 ). Figure 1 Aldosterone/MR signaling. Aldosterone (aldo) has several mechanisms of action. (1) It can bind to cytosolic MR and initiate translocation of MR into the nucleus, where the MR homodimerizes and acts as a transcription factor
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quantitative real-time PCR analyses of c-Fms (B) and RANK (C) at 24–96 h are shown. In (D), the semi-quantitative RT-PCR analyses of the mRNA expression of the transcription factors c-Fos, c-Jun, NFAT-2 and the mRNA expression of IκBα, the inhibitory component
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Introduction Diabetic nephropathy is one of the most serious micro-vascular complications. The diabetic milieu results in the increased expression of angiogenic growth factors in numerous tissues in response to both hyperglycemia and
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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, NF-κB was found to be up-regulated in human pituitary adenomas ( Chen et al . 2015 ), with its pharmacological inhibition reducing cell viability in the GH3 pituitary cell line ( Vender et al . 2008 ), the role of this key transcription factor in
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the phospholipase A2 in the cytoplasm and several transcription factors in the nucleus like the proto-oncogene c-fos ( Janknecht et al. 1995 ), which plays a pivotal role in preadipocyte growth induction ( Lacasa et al. 1997 a , b ). The
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transcription factors to regulate gene expression and composite binding in which GC/GR requires both GRE elements and physical interaction with other transcription factors to exert its transcriptional activity. BTM: basal transcription machinery. Once
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium
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St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia
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controlled activation/repression of specific transcription factors and downstream gene clusters in a time-dependent manner. These complex signalling events drive the transition from definitive endoderm cells to mature insulin-secreting β-cells with the