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Eloise A Bradley Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

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Dino Premilovac Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia

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Andrew C Betik Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia

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Donghua Hu Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

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Emily Attrill School of Medicine, University of Tasmania, Hobart, Tasmania, Australia

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Stephen M Richards Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia

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Stephen Rattigan Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

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Michelle A Keske Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia

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Microvascular blood flow was determined by measuring metabolism of infused 1-methylxanthine (1-MX, Sigma-Aldrich), a substrate targeted for xanthine oxidase, that is located predominantly in capillary endothelium in rat leg muscle ( Jarasch et al. 1986 ). This

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Christian Hölscher Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK

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apoptosis-related signalling. Furthermore, exendin-4 can reduce monocyte adhesion to aortic endothelium in an inflammatory response in atherosclerosis and also prevents LPS-induced cytokine and chemokine release in both human and mouse monocytes ( Arakawa

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M B Mazzucco Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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R Higa Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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E Capobianco Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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M Kurtz Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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A Jawerbaum Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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V White Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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human endothelium of umbilical veins and arteries ( Akerman et al . 2002 ). Other studies have shown that administration of leptin induces a threefold increase in leptinemia in both fetuses and adult animals ( de Oliveira et al . 2007 , Su et al

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Jung-Hoon Kang Internal Medicine, Department of Internal Medicine, Departments of

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Seo-Yoon Chang Internal Medicine, Department of Internal Medicine, Departments of

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Hyun-Jong Jang Internal Medicine, Department of Internal Medicine, Departments of

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Dong-Bin Kim Internal Medicine, Department of Internal Medicine, Departments of

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Gyeong Ryul Ryu Internal Medicine, Department of Internal Medicine, Departments of

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Seung Hyun Ko Internal Medicine, Department of Internal Medicine, Departments of

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In-Kyung Jeong Internal Medicine, Department of Internal Medicine, Departments of

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Yang-Hyeok Jo Internal Medicine, Department of Internal Medicine, Departments of

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Myung-Jun Kim Internal Medicine, Department of Internal Medicine, Departments of

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aortic smooth muscle ( Koide et al . 1993 ), brown adipose tissue ( Nisoli et al . 1997 ), and brain endothelium ( Durieu-Trautmann et al . 1993 ) while cAMP decreased iNOS expression in pancreatic cells ( Andersen et al . 1996 ) and rat hepatocytes

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Graham W Aberdeen Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Jeffery S Babischkin Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Mediation by M 3 -muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat . British Journal of Pharmacology 112 519 – 524 . ( https://doi.org/10.1111/j.1476

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G Basini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S Bussolati Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S E Santini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Bianchi Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Careri Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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A Mangia Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Musci Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Grasselli Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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-hydroxyestrogens in polycystic ovary syndrome . Journal of Clinical Endocrinology and Metabolism 92 3285 – 3291 . Sato Y 2006 Update on endogenous inhibitors of angiogenesis . Endothelium 13 147 – 155 . Shelhamer JH Volkman DJ Parrillo JE

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Cintia B Ueta Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil
Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Gustavo W Fernandes Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Luciane P Capelo Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Tatiane L Fonseca Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Flávia D'Angelo Maculan Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Cecilia H A Gouveia Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Patrícia C Brum Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Marcelo A Christoffolete Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Marcelo S Aoki Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Carmen L Lancellotti Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Brian Kim Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Antonio C Bianco Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Miriam O Ribeiro Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Therapeutics 261 638 – 642 . Huang Y Kwok KH Chan NW Lau CW Chen ZY 1998 Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery . Clinical and Experimental Pharmacology & Physiology 25 405 – 411

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E Louiset INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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V Contesse INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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L Groussin INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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D Cartier INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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C Duparc INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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V Perraudin INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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J Bertherat INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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H Lefebvre INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France
INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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impartiality of this scientific work. References Aldasoro M Medina P Vila JM Otero E Martinez-Leon JB Lluch S 1997 Endothelium-dependent relaxation of human saphenous veins in response to vasopressin and desmopressin . Journal of Vascular Surgery

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Constanze Hantel
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Felicitas Lewrick Endocrine Research Unit, Department of Pharmaceutical Technology and Biopharmacy, Medizinische Klinik and Poliklinik IV, Ludwig‐Maximilians‐University, Ziemssenstraße 1, D-80336 Munich, Germany

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Martin Reincke
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Regine Süss Endocrine Research Unit, Department of Pharmaceutical Technology and Biopharmacy, Medizinische Klinik and Poliklinik IV, Ludwig‐Maximilians‐University, Ziemssenstraße 1, D-80336 Munich, Germany

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Felix Beuschlein
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toxicity based on the modified biodistribution of the drug ( Gabizon et al . 1982 ). The relatively large size of liposomal carriers (45–200 nm) prevents them from passing through the 2 nm pores found in the endothelium of blood vessels in most healthy

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Anna Cinkajzlová Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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, reduces the expression of insulin-regulated glucose transporter type 4 located in adipocytes and skeletal and cardiac muscles TNFα : involved in atherosclerosis progression, stimulates interaction between leukocytes and the endothelium through

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