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Natasha N Chattergoon Center for Developmental Health, Oregon Health and Science University, Portland, Oregon, USA
Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA

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( Barker et al. 1989 , Barker 1995 ). We now know the importance of the prenatal environment in determining risk for CVD throughout life via a process known as fetal programming ( Barker & Osmond 1988 , Gluckman et al. 2008 ). There is increasing

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0704
Volume/Issue:
Volume 242: Issue 1
Free access
Kimberley C W Wang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Kimberley J Botting Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Song Zhang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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I Caroline McMillen Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Doug A Brooks Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Janna L Morrison Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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et al . 1993 ). Furthermore, the altered left ventricular hypertrophy was transmitted to the F2 offspring in rats, indicating transgenerational programming effects of IUGR ( Master et al . 2014 ). Left ventricular hypertrophy in adulthood is also

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0039
Volume/Issue:
Volume 233: Issue 2
Free access
Tessa J Roseboom Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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diseases have their origins in utero , but that they are programmed through different environmental influences (which may include not only fetal growth restriction, but also limited food supply). There were effects of prenatal famine exposure in the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0683
Volume/Issue:
Volume 242: Issue 1
Free access
Anna H Kongsted
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Sanne V Husted
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Malin P Thygesen Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Vibeke G Christensen
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Dominique Blache Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Anders Tolver Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Torben Larsen Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Bjørn Quistorff Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Mette O Nielsen
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according to the so-called predictive adaptive hypothesis can be explained by the programming/adaptation of the metabolic and endocrine functions of the foetus to make it prepared to be born into a world with stressful conditions and scarcity of food

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0099
Volume/Issue:
Volume 219: Issue 2
Free access
Jose Casasnovas Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Yunhee Jo Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Xi Rao Center for Medical Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Xiaoling Xuei Center for Medical Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Mary E Brown The Indiana Center for Biological Microscopy, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Kok Lim Kua Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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hyperglycemia on pancreatic islets of offspring, uncovering a primary mechanism of offspring pancreatic islet programming. We hypothesize that maternal hyperglycemia alters the offspring pancreatic islet transcriptome, consequently conferring increased offspring

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0493
Volume/Issue:
Volume 240: Issue 2
Free access
Peter Kolkhof Drug Discovery, Cardiology Research, Bayer AG, Wuppertal, Germany

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Lars Bärfacker Drug Discovery, Medicinal Chemistry, Bayer AG, Wuppertal, Germany

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2004 ). One chemistry program at Searle was originally focused on ‘cardioregulatory agents specifically for treating cardiac arrhythmias’ ( Fitzgerald & Fitzgerald 2009 ), probably based on the attempt to combine parts of the steroidal structures of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0600
Volume/Issue:
Volume 234: Issue 1
Open access
Pauline C Xu Olson Center for Women’s Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska

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Yi Luan Olson Center for Women’s Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska

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Seok-Yeong Yu Olson Center for Women’s Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska

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Jing Xu Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon
Department of Obstetrics and Gynecology, School of Medicine, Oregon Health & Science University, Portland, Oregon

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Donald W Coulter Division of Pediatric Hematology/Oncology, Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska

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So-Youn Kim Olson Center for Women’s Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska

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one of the most promising targets. This class of immunotherapy aims to augment the patient’s antitumor immune response by blocking immune checkpoint molecules. One such molecule is programmed cell death protein 1 (PD-1), which normally functions to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0209
Volume/Issue:
Volume 252: Issue 1
Restricted access
Graham W Aberdeen Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Jeffery S Babischkin Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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disturbing trend. The hormonal milieu of pregnancy has an extremely important role in programming the developmental events in the fetus that control metabolic function after birth in the offspring ( Hoffman et al. 2021 ). Thus, circumstances in which the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0364
Volume/Issue:
Volume 262: Issue 1
Open access
Camilla Alexanderson
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Elias Eriksson Department of Physiology, Department of Pharmacology, Wallenberg Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Box 434, SE-405 30 Göteborg, Sweden

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Elisabet Stener-Victorin
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Malin Lönn Department of Physiology, Department of Pharmacology, Wallenberg Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Box 434, SE-405 30 Göteborg, Sweden

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Agneta Holmäng
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in a predisposition to metabolic and endocrine disease in adulthood ( Barker 1990 , Lucas 1991 , Barker et al . 1993 ). In humans and animals, perinatal programming may contribute to inappropriate insulin sensitivity by affecting glucose and lipid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0534
Volume/Issue:
Volume 201: Issue 1
Free access
Noelia Martínez-Sánchez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José M Moreno-Navarrete CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Cristina Contreras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Eva Rial-Pensado Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José-Manuel Fernández-Real CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Miguel López Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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action of T 3 targets one particular hypothalamic nucleus, the VMH. Indeed, stereotaxic administration of the hormone into the ARC (a neighboring nucleus) did not recapitulate the effects on the browning program induced by T 3 within the VMH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0425
Volume/Issue:
Volume 232: Issue 2
Open access