Search Results
Search for other papers by Sébastien Marion in
Google Scholar
PubMed
Search for other papers by Elodie Kara in
Google Scholar
PubMed
Search for other papers by Pascale Crepieux in
Google Scholar
PubMed
Search for other papers by Vincent Piketty in
Google Scholar
PubMed
Search for other papers by Nadine Martinat in
Google Scholar
PubMed
Search for other papers by Florian Guillou in
Google Scholar
PubMed
Search for other papers by Eric Reiter in
Google Scholar
PubMed
). Notably, in the studies published to date, the different partners (i.e. the GRK, the β-arrestin or the FSH-R) were heterogenously overexpressed. We have shown that GRKs and β-arrestins were able to uncouple the FSH-induced cAMP response in rat primary
Search for other papers by Andreas Börjesson in
Google Scholar
PubMed
Search for other papers by Carina Carlsson in
Google Scholar
PubMed
the onset of type I diabetes (T1D) and in relatives of T1D patients ( Ludvigsson & Heding 1982 , Hartling et al. 1989 , Snorgaard et al. 1990 ). In rat models of hyperglycaemia, increased ratios of circulating proinsulin to insulin have been
Search for other papers by A. HOWE in
Google Scholar
PubMed
Search for other papers by P. A. JEWELL in
Google Scholar
PubMed
SUMMARY
The effects of dehydration, brought about by water deprivation over a period of 10 days, upon the stainable neurosecretory material (NSM) of the hypothalamo-hypophysial system were compared in two species of rodents originating from different climatic habitats, namely the laboratory rat (Rattus norvegicus) and the desert rat (Meriones meriones).
While the neural lobe of the laboratory rat was virtually completely depleted of NSM by this procedure, that of the desert rat showed no detectable histological changes. No striking changes were found in the hypothalamus of either species following this period of water deprivation, although there was some indication of disappearance of NSM from the hypothalamus in the desert rat.
The results are briefly discussed in relation to the theory of hypothalamic neurosecretion.
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by Y Okuma in
Google Scholar
PubMed
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by A E O’Connor in
Google Scholar
PubMed
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by J A Muir in
Google Scholar
PubMed
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by P G Stanton in
Google Scholar
PubMed
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by D M de Kretser in
Google Scholar
PubMed
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
Search for other papers by M P Hedger in
Google Scholar
PubMed
LPS do not reduce intratesticular levels of testosterone in the rat much below 30% of normal, which is well above the threshold necessary to sustain spermatogenesis in this species ( Sharpe et al. 1988 , McLachlan et al. 1996 ). Altogether, the
Search for other papers by S. M. TRIGGS in
Google Scholar
PubMed
Search for other papers by R. D. HESCH in
Google Scholar
PubMed
Search for other papers by J. S. WOODHEAD in
Google Scholar
PubMed
Search for other papers by E. D. WILLIAMS in
Google Scholar
PubMed
SUMMARY
Immunolocalization techniques have been used to study 16 rat thyroids containing C cell tumours and ten rat thyroids in which no tumours or hyperplasias were found. All rats in these groups were at least 2 years old. An indirect ('sandwich') technique was used which involved rabbit or goat anti-human calcitonin antiserum and either fluorescein or peroxidase-labelled anti-rabbit or anti-goat IgG.
Plasma calcitonin levels were measured in these animals and in a further group of ten young normal rats by means of an immunoradiometric assay using goat antiserum against synthetic human calcitonin.
Both normal C cells and C cell tumours showed either apple-green fluorescence or positive peroxidase staining. The intensity of staining in the tumours varied from one cell to another but was in general less than that found for normal C cells. Calcitonin in the blood was detectable in most animals. The mean concentration found in young normal animals was 265 pg/ml (range < 100–600 pg/ml), in old normal animals 160 pg/ml (range < 100– 400 pg/ml) and in rats with small C cell tumours 470 pg/ml (range 100–1200 pg/ml). The mean concentration in this latter group differed significantly from those of both normal groups (P < 0·05). One animal with an invasive C cell tumour had a greatly increased calcitonin concentration (> 5 ng/ml) in the circulation.
The results showed that calcitonin was present in normal rat C cells and that C cell tumours both contained and secreted calcitonin, underlining the similarity between these tumours and human medullary carcinomata.
Search for other papers by R A Silvestre in
Google Scholar
PubMed
Search for other papers by E M Egido in
Google Scholar
PubMed
Search for other papers by R Hernández in
Google Scholar
PubMed
Search for other papers by J Marco in
Google Scholar
PubMed
cloned from rat brain ( Lee et al . 1999 ). Tissue distribution of GPR54 and its cognate ligand precursor, KISS1, often coincides. The levels of the transcripts of both are the highest in the placenta ( Lee et al . 1996 , Kotani et al . 2001
Search for other papers by Claudia Gentili in
Google Scholar
PubMed
Search for other papers by Ricardo Boland in
Google Scholar
PubMed
Search for other papers by Ana Russo de Boland in
Google Scholar
PubMed
Introduction Parathyroid hormone (PTH) is an 84-amino-acid polypeptide hormone functioning as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis ( Rosenblatt et al. 1989 ). In rat intestinal
Search for other papers by D. R. INMAN in
Google Scholar
PubMed
Search for other papers by R. E. W. BANFIELD in
Google Scholar
PubMed
Search for other papers by R. J. B. KING in
Google Scholar
PubMed
SUMMARY
The intracellular localization of [6,7-3H]oestradiol in rat pituitary, liver and uterus has been studied using autoradiography. In the anterior pituitary the oestrogen has been located on the nuclear membrane and nucleolus of the eosinophils. The posterior pituitary did not produce positive autoradiographs and only occasional silver grains were seen in the pars intermedia. In the liver the silver grains were uniformly distributed throughout the cytoplasm; only very occasionally were grains associated with the nucleus. No satisfactory results were obtained with the uterus. Labelled erythrocytes were seen in all the tissues studied. The results are discussed in relation to the mode of action of oestradiol.
Search for other papers by Nina N Atanassova in
Google Scholar
PubMed
Search for other papers by Marion Walker in
Google Scholar
PubMed
Search for other papers by Chris McKinnell in
Google Scholar
PubMed
Search for other papers by Jane S Fisher in
Google Scholar
PubMed
Search for other papers by Richard M Sharpe in
Google Scholar
PubMed
androgens on Sertoli cell number in the rat, but also point to a role for oestrogens in addition to the accepted role of FSH. Materials and Methods Animals, treatments, sample collection and processing All animal
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Michelle W M Li in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Weiliang Xia in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Dolores D Mruk in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Claire Q F Wang in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Helen H N Yan in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Michelle K Y Siu in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Wing-yee Lui in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by Will M Lee in
Google Scholar
PubMed
Department of Zoology, The University of Hong Kong, Hong Kong, China
Search for other papers by C Yan Cheng in
Google Scholar
PubMed
vitro studies have indeed demonstrated that TNFα is a potential crucial regulator of junction dynamics using Sertoli cells cultured in vitro. For instance, treatment of primary rat Sertoli cell cultures during tight junction (TJ) assembly with TNFα
