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Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan
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Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan
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attractive means of preventing and/or treating type 1 diabetes. Identifying novel targets that protect β-cells from damage related to type 1 diabetes is an important goal, and searches for such targets have been widely conducted. The transcription factor
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Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
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depends on the expression of key transcription factors such as PDX-1 and PTF1α within the ductal cells ( Murtaugh 2007 ). PDX-1 is also required in the mature β-cell where it trans-activates the insulin and GLUT2 gene promoters. Other transcription factors
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quantitative real-time PCR analyses of c-Fms (B) and RANK (C) at 24–96 h are shown. In (D), the semi-quantitative RT-PCR analyses of the mRNA expression of the transcription factors c-Fos, c-Jun, NFAT-2 and the mRNA expression of IκBα, the inhibitory component
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing 10009, China
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cholesterol from mitochondrial outer membrane to inner membrane, where cytochrome P450 side-chain cleavage enzyme (P450 scc) resides ( Christenson & Strauss 2000 , Stocco 2000 ). StAR expression is regulated by several transcription factors such as DAX-1
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Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA
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Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA
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binding DNA-response elements (TREs) in the proximal promoters of target genes as heterodimers with retinoid X receptors (RXRs) but can also regulate target genes via protein–protein interactions with heterologous transcription factors ( Baxter & Webb 2009
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Hawaii Institute of Marine Biology, Department of Molecular Biosciences and Bioengineering, Department of Biology and Center for Neuroendocrine Studies, University of Hawaii, Kaneohe, Hawaii 96744, USA
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Hawaii Institute of Marine Biology, Department of Molecular Biosciences and Bioengineering, Department of Biology and Center for Neuroendocrine Studies, University of Hawaii, Kaneohe, Hawaii 96744, USA
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Hawaii Institute of Marine Biology, Department of Molecular Biosciences and Bioengineering, Department of Biology and Center for Neuroendocrine Studies, University of Hawaii, Kaneohe, Hawaii 96744, USA
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PrlRs exhibit changes in expression in the pituitary following salinity challenges. Lastly, we explored the effects of acclimation salinity and extracellular osmolality on the gene expression of osmotic stress transcription factor 1 ( ostf1 ) in the RPD
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sequence called the oestrogen response element (ERE), which is usually located upstream of the promoter and displays enhancer properties. For regulation of gene transcription, ER has to interact with basal transcription factors and RNA polymerase II ( Jacq
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associated with proliferation (PCNA), apoptosis (Bax), TK (phosphotyrosine), Cdc2/p34, PKA and PKA-activated transcription factor (CREB-1) in cultured porcine ovarian cells. We also investigated how TPO influences the secretion of progesterone
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Orthopaedic Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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known to activate multiple transcription factors important in bone formation ( Kanczler et al. 1998 ). The importance of oxidants as signaling molecules suggests, therefore, that global inhibition of oxidation with antioxidant supplementation might
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transcription factor 4 (ATF4), GRP78 (Santa Cruz), eukaryotic initiation factor 2α (eIF2α), p-eIF2α (Cell Signalling), CHOP-10, β-actin, histone H3 (Sigma). The dilution used in all cases was 1:1000. Incubation lasted for 4 h at room temperature. The membrane