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Simon Klebanov The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Clinton M Astle The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Olga DeSimone The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Vitaly Ablamunits The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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David E Harrison The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Introduction Leptin, a major hormone secreted by white adipose tissue (WAT) ( Zhang et al. 1994 ), has been implicated in the regulation of body weight ( Baskin et al. 2001 , Mantzoros 2001 ), glucose metabolism ( Fruhbeck

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Silvana Y Romero-Zerbo Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Alex Rafacho Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Adenis Díaz-Arteaga Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Juan Suárez Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ivan Quesada Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Mónica Imbernon Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ruth A Ross Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Carlos Dieguez Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Fernando Rodríguez de Fonseca Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Rubén Nogueiras Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ángel Nadal Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Francisco J Bermúdez-Silva Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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neuropathic pain ( Staton et al . 2008 ) and in bone physiology ( Whyte et al . 2009 ). In this latter study, the GPR55 agonist O-1602 inhibited mouse osteoclast formation, an effect that was not seen in osteoclasts generated from GPR55 −/− bone marrow

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Harman S Mattu Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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Harpal S Randeva Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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nutrition) have been shown to interact (including through metabolic syndrome, MetS) and contribute to CVD. White adipose tissue (WAT) has been identified as a metabolically active endocrine organ that affects a plethora of body functions including energy and

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Michael G White Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Hussain R Al-Turaifi Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Graham N Holliman Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Ali Aldibbiat Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Aiman Mahmoud Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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James A M Shaw Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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R Ancans J 2009 Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis . Stem Cell Reviews 5 378 – 386 . doi:10.1007/s12015-009-9094-9 . Russ HA Bar Y

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Noriko Sakai
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Hiromi Terami
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Shinobu Suzuki
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Megumi Haga
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Ken Nomoto
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Nobuko Tsuchida
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Ken-ichirou Morohashi Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Naoaki Saito Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Maki Asada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Megumi Hashimoto Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Daisuke Harada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Hiroshi Asahara Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Tetsuya Ishikawa
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Fumiki Shimada
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Kazuhiro Sakurada
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marrow-derived MSCs and HEK293 cells for the large-scale functional screening. Human bone marrow-derived MSCs were chosen as an alternative to ovarian MSCs, since it has been reported that MSCs isolated from different tissues share common features

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Eduardo Esteban-Zubero Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Francisco Agustín García-Gil Department of Surgery, Gynaecology and Obstetrics, University of Zaragoza, Zaragoza, Spain

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Laura López-Pingarrón Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Moisés Alejandro Alatorre-Jiménez Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Pablo Iñigo-Gil Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Dun-Xian Tan Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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José Joaquín García Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Russel J Reiter Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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antioxidant ( Tan et al . 1993 , Rodriguez et al. 2004 , Zhang & Zhang 2014 , Galano et al. 2015 , Manchester et al. 2015 ) produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta and liver

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Brittany M Duggan Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Daniel M Marko Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Raveen Muzaffar Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Darryl Y Chan Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Jonathan D Schertzer Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Limit Diet-Induced Fat Tissue Expansion: role of Local versus Bone Marrow-Derived Endothelial Cells . PLoS One 4 e4974 . ( https://doi.org/10.1371/JOURNAL.PONE.0004974 ) Tao L Yi Y Chen Y Zhang H Orning P Lien E Jie J Zhang W Xu Q Li

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Stephan Pinheiro Frankenfeld Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Leonardo Pires de Oliveira Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Daniele Leão Ignacio Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Raquel Guimarães Coelho Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Mariana Nigro Mattos Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Andrea Claudia Freitas Ferreira Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Denise Pires Carvalho Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Rodrigo Soares Fortunato Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Laboratory of Exercise Biology, Laboratory of Bioenergetics, Institute of Biophysics Carlos Chagas Filho, UFRJ, CCS

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Introduction Anabolic–androgenic steroids are synthetic molecules similar to the male sex hormone testosterone. These substances are classically used for the treatment of hypogonadism, bone marrow failure syndromes, bone mineralization, and some

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Julie A Meyers Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Amy Y Liu Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Anne McTiernan Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Mark H Wener Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Brent Wood Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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David S Weigle Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Bess Sorensen Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Zehava Chen-Levy Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Yutaka Yasui Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Alanna Boynton Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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John D Potter Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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Cornelia M Ulrich Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA
Fred Hutchinson Cancer Research Center, Department of Epidemiology, Division of Metabolism, Department of Public Health Sciences, Cancer Prevention Program, 1100 Fairview Avenue N., Seattle, Washington 98109, USA

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least partially mediated via adipose tissue. However, unlike van Dielen et al . (2001) , we observed that the association between leptin and CRP and SAA remained statistically significant after statistical adjustment for either BMI or percent body fat

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Mark Nixon Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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Rita Upreti Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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manipulation of intracellular interactions of nuclear hormone receptors with co-regulators or co-repressors has led to selectivity of actions (oestrogenic effects on reproductive tissues vs bone; Smith & O'Malley 2004 ). Endogenous steroids have been utilised

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