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S Ramaswamy
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C R Pohl
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G R Marshall
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T M Plant
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through the vascular endothelium. Journal of Endocrinology 145 1 –9. Gnessi L , Fabri A & Spera G 1997 Gonadal peptides as mediators of development and functional control of the testis: An integrated system with hormones

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Omer Turker Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Kamil Kumanlioglu Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Inanc Karapolat Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Ismail Dogan Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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. Selenoprotein P is the Se transport protein and is an antioxidant on endothelium. The other types of selenoproteins are defined as H, I, K, M, N, O, R, S, T, and V, and most of their functions are still unknown ( Beckett & Arthur 2005 ). In Turkey, there

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Abby J Sarkar Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Kirti Chaturvedi Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Cui Ping Chen Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Dipak K Sarkar Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. Journal of Clinical Pathology 43 752 –757. Relf M , LeJeune S & Scott PA 1997 Expression of the angiogenic factors

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M Zerani Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Boiti Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Dall’Aglio Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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L Pascucci Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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M Maranesi Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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G Brecchia Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Mariottini Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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G Guelfi Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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D Zampini Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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A Gobbetti Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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–339. Kimura K , Tsuda K, Baba A, Kawabe T, Bohoka S, Ibata M, Moriwaki C, Hano T & Nishio I 2000 Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochemical and Biophysical Research

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Jennifer J DuPont Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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Iris Z Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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et al. 2015 ). Although aortic endothelium-dependent relaxation was normal in healthy EC-MR-KO mice ( Schäfer et al. 2013 ), female EC-MR-KO mice were protected from aortic endothelial dysfunction, vascular stiffness and cardiac diastolic

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Kazuhiko Imakawa Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Kasama, Ibaraki, Japan

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Rulan Bai Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Kasama, Ibaraki, Japan

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Hiroshi Fujiwara Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan

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Atsushi Ideta Zennoh Embryo Transfer Center, Kamishihoro, Hokkaido, Japan

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Yoshito Aoyagi Zennoh Embryo Transfer Center, Kamishihoro, Hokkaido, Japan

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Kazuya Kusama Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Kasama, Ibaraki, Japan

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the endothelium of the maternal capillaries is located close to the TE cells, resulting from stromal thinning and a loss of uterine epithelium. A hemochorial placentation, by contrast, is seen in many rodents and in higher primates including humans, in

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Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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and endothelium that is damaged during enzymatic dissociation of islets. Mesenchymal stem cells (MSC), implicated in tissue repair and maintenance of cellular homeostasis, secrete factors with anti-inflammatory, proangiogenic and regenerative

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Antonia Hufnagel University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Laura Dearden University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Denise S Fernandez-Twinn University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Susan E Ozanne University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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. 2018 ). In 1994 Desoye et al . reported that insulin receptor protein expression shifts from the maternal facing side of the placenta (the syncytiotrophoblast) to the fetal facing side of the placenta (the fetal endothelium) with advancing gestation in

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Morag J Young Baker Heart and Diabetes Institute, Prahran, Australia
Hudson Institute of Medical Research, Clayton, Australia

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Colin D Clyne Hudson Institute of Medical Research, Clayton, Australia

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Karen E Chapman The University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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reflect dysfunction of the endothelium ( Sardu et al. 2020 ). Hypertension, a common comorbidity in patients with COVID-19 (as stated previously), is associated with an increased risk of thrombosis – and in particular a ‘sepsis-induced coagulopathy

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Neerav Mullur The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Arianne Morissette The University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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Nadya M Morrow The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Erin E Mulvihill The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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fibrosis, endothelial dysfunction, oxidative stress, and vascular inflammation. More precisely, liraglutide prevented leukocyte rolling on the endothelium and infiltration of myeloid Ly6G − Ly6C + and Ly6G + Ly6C + cells into the vascular wall, which

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