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Kristen R Lednovich Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sophie Gough Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Medha Priyadarshini Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Nupur Pandya Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Chioma Nnyamah Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Kai Xu Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Barton Wicksteed Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sidharth Mishra USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Shalini Jain USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Joseph L Zapater Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Hariom Yadav USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Brian T Layden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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that SCFAs are able to carry out their physiological effects is through binding to their cognate receptors, including FFA2. FFA2 is broadly expressed in many metabolically active tissues, including the intestine, endocrine pancreas, adipose tissue and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0184
Volume/Issue:
Volume 260: Issue 2
Open access
Shuang-Xia Zhao
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Shanli Tsui Department of Diabetes and Endocrinology, Department of Medicine, Ophthalmology and Visual Sciences, Internal Medicine, King's College London School of Medicine, London, UK

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Anthony Cheung
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Raymond S Douglas Department of Diabetes and Endocrinology, Department of Medicine, Ophthalmology and Visual Sciences, Internal Medicine, King's College London School of Medicine, London, UK
Department of Diabetes and Endocrinology, Department of Medicine, Ophthalmology and Visual Sciences, Internal Medicine, King's College London School of Medicine, London, UK

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Terry J Smith Department of Diabetes and Endocrinology, Department of Medicine, Ophthalmology and Visual Sciences, Internal Medicine, King's College London School of Medicine, London, UK
Department of Diabetes and Endocrinology, Department of Medicine, Ophthalmology and Visual Sciences, Internal Medicine, King's College London School of Medicine, London, UK

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J Paul Banga
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TSHR and IGF1R ( Bell et al . 2000 , Zhang et al . 2009 ) and represent the key participants in orbital tissue remodeling in GO ( Smith 2003 ), Recently, bone marrow-derived CD34 + fibrocytes have been detected among the fibroblasts inhabiting the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0162
Volume/Issue:
Volume 210: Issue 3
Open access
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Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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shown that cultured intermuscular adipocytes produce pro-diabetic substances, providing evidence of a causal relationship ( Laurens et al. 2016 ). Additionally, a mechanistic link between expansion of visceral adipose tissue and muscle atrophy has been

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
Open access
Corinne Caillaud Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Mie Mechta Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Heidi Ainge Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Andreas N Madsen Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Patricia Ruell Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Emilie Mas Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Catherine Bisbal Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Jacques Mercier Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Stephen Twigg Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Trevor A Mori Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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David Simar Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Romain Barrès Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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from EPO-treated animals resulted from an indirect action of EPO on this tissue. Figure 6 While EPOR is expressed in muscle cells, EPO does not stimulate glucose uptake or glycogen synthesis in cultured myotubes. (A) EPOR expression in bone marrow

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0010
Volume/Issue:
Volume 225: Issue 2
Open access
Alessandra Fierabracci Research Laboratories, Ospedale Pediatrico Bambino Gesù Research Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio, 4, 00165 Rome, Italy

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the generation of autoimmune responses. Stem/progenitor cells derived from bone marrow It has also been suggested that in many high- and low-proliferating organs, stem/progenitor cells are furnished by bone marrow ( Sherwood et al . 2004 , Klonisch

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0183
Volume/Issue:
Volume 213: Issue 1
Free access
Odelia Katz
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Matthew Stuible Department of Cell and Developmental Biology, Department of Medicine A, Goodman Cancer Centre and Department of Biochemistry, Institute for Veterinary Physiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Nathalia Golishevski Department of Cell and Developmental Biology, Department of Medicine A, Goodman Cancer Centre and Department of Biochemistry, Institute for Veterinary Physiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Lilach Lifshitz
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Michel L Tremblay Department of Cell and Developmental Biology, Department of Medicine A, Goodman Cancer Centre and Department of Biochemistry, Institute for Veterinary Physiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Max Gassmann Department of Cell and Developmental Biology, Department of Medicine A, Goodman Cancer Centre and Department of Biochemistry, Institute for Veterinary Physiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Moshe Mittelman Department of Cell and Developmental Biology, Department of Medicine A, Goodman Cancer Centre and Department of Biochemistry, Institute for Veterinary Physiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Drorit Neumann
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Introduction The hematopoietic growth factor erythropoietin (EPO) is produced in the kidney in response to hypoxia, and stimulates erythropoiesis in the bone marrow ( Krantz 1991 , Spivak et al . 1991 ). Recombinant human EPO (rHuEPO) is an

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0425
Volume/Issue:
Volume 205: Issue 1
Free access
Naomi Fleury Telethon Kids Institute, University of Western Australia, Perth, Australia

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Martin Feelisch Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK

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Prue H Hart Telethon Kids Institute, University of Western Australia, Perth, Australia

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Richard B Weller University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, Scotland

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Jordan Smoothy Telethon Kids Institute, University of Western Australia, Perth, Australia

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Vance B Matthews School of Medicine and Pharmacology – Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia

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Shelley Gorman Telethon Kids Institute, University of Western Australia, Perth, Australia

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the experiment, liver and gonadal deposits of white adipose tissue and interscapular deposits of brown adipose tissue were dissected from mice and their weights were determined using an analytical scale (Analytical Standard Electric Balance, Ohaus, NJ

Article Type:
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DOI:
https://doi.org/10.1530/JOE-16-0616
Volume/Issue:
Volume 233: Issue 1
Free access
Ricardo Rodríguez-Calvo Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Josefa Girona Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Josep M Alegret Department of Cardiology, Cardiovascular Research Group, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Reus, Spain

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Alba Bosquet Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Daiana Ibarretxe Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Lluís Masana Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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be involved in the elevated risk of HF. Both visceral obesity and ectopic fat accumulation in non-adipose tissues, including the heart, have been related to cardiac structure abnormalities and increased cardiometabolic risk ( Britton & Fox 2011

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0031
Volume/Issue:
Volume 233: Issue 3
Free access
David A Taylor-Fishwick Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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Angela Bowman Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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Natasha Hamblet Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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Paul Bernard Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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David M Harlan Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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Aaron I Vinik Departments of Internal Medicine,
Microbiology and Molecular Cell Biology,
Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA

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stomach, spleen, duodenum, liver, kidney, lung, skeletal muscle, brain, heart, or bone marrow (data not shown). Since endogenous elastase is also detected in the stomach ( Kruse et al. 1993 ), this expression pattern supports a restricted expression of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06698
Volume/Issue:
Volume 190: Issue 3
Free access
Cheng-Hsu Wang Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung 204, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Taoyuan 333, Taiwan

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Yung-Chi Shen Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung 204, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Taoyuan 333, Taiwan

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Jia-Juan Hsieh Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung 204, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Taoyuan 333, Taiwan

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Kun-Yun Yeh Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung 204, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Taoyuan 333, Taiwan

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John Wen-Cheng Chang Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung 204, Taiwan
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Taoyuan 333, Taiwan

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Introduction Cachexia is a paraneoplastic syndrome manifested as progressive weight loss with depletion of adipose tissue and skeletal muscle, and contributes to a poor quality of life, which is observed in about half of all the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06490
Volume/Issue:
Volume 190: Issue 2
Free access