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Qiongge Zhang Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Chaoqun Wang Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Yehua Tang Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Qiangqiang Zhu Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China

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Yongcheng Li Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China

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Haiyan Chen Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Yi Bao Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Song Xue Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Liangliang Sun Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Wei Tang Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Xiangfang Chen Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Yongquan Shi Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Lefeng Qu Department of Vascular and Endovascular Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Bin Lu Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China

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Jiaoyang Zheng Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, China

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. The regulation of OPN transcription has been reported to require the concerted action of various transcription factors or cofactors, such as AP-1 ( Renault et al. 2003 ), Ets-1 and Runx2 ( Inman & Shore 2003 , Wai et al. 2006 , Abe et al. 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0594
Volume/Issue:
Volume 242: Issue 2
Free access
Anna E Bollag Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Tianyang Guo Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Vivek Choudhary Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Xunsheng Chen Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Qing Zhong Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Mohamed E Awad Department of Oral Biology, Dental College of Georgia at Augusta University, Augusta, Georgia, USA

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Mohammed Elsalanty Department of Oral Biology, Dental College of Georgia at Augusta University, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Wendy B Bollag Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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known to activate multiple transcription factors important in bone formation ( Kanczler et al. 1998 ). The importance of oxidants as signaling molecules suggests, therefore, that global inhibition of oxidation with antioxidant supplementation might

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0691
Volume/Issue:
Volume 243: Issue 1
Free access
Xiaojiong Du Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Sirong He Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Yaowen Jiang Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Lingling Wei Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Weiming Hu Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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), cyclooxygenase 2 (COX2), and transcription nuclear factor-κB (NF-κB), as well as inhibition of the inducible isoform of NO synthase. Ischemia–reperfusion injury is the key factor associated with islet graft dysfunction at early stages of the transplant procedure

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0568
Volume/Issue:
Volume 218: Issue 1
Free access
Che-Pei Kung Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA

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Maureen E Murphy Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA

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in genes whose protein products control p53 activity (MDM2 or CDKN2A). Following genotoxic or oncogenic stress, p53 exerts its tumor-suppressive activities mainly by acting as a transcription factor to transactivate gene expression. Under mild stress

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0324
Volume/Issue:
Volume 231: Issue 2
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Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Hydrolase Exp Exp Exp Exp HIGD1A HIG1 hypoxia inducible domain family member 1A Scaffold/adaptor protein Exp Exp Exp Exp IRX2 Iroquois homeobox 2 Homeodomain transcription factor Exp Exp Exp Exp KCTD12

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Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0298
Volume/Issue:
Volume 258: Issue 1
Free access
C D Simmons
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J M P Pabona
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Z Zeng
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M C Velarde
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D Gaddy
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F A Simmen
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R C M Simmen Department of Physiology and Biophysics, Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, Arkansas 72202, USA

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precise mechanisms and participating molecules remain poorly understood. Krüppel-like factor (KLF) 9, a member of the Sp/KLF family of transcription factors ( Suske et al . 2005 ), is a 244-amino acid protein characterized by three C-terminal zinc finger

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0474
Volume/Issue:
Volume 205: Issue 2
Free access
Aijun Zhang Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Douglas H Sieglaff Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Jean Philippe York Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Ji Ho Suh Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Stephen D Ayers Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Glenn E Winnier Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Alexei Kharitonenkov Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Christopher Pin Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA
Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Pumin Zhang Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Paul Webb Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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Xuefeng Xia Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA
Houston Methodist Research Institute, College of Arts and Sciences, Departments of Paediatrics, Children's Health Research Institute, Department of Molecular Physiology and Biophysics, The Third Affiliated Hospital of Guangzhou Medical University, Genomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USA

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binding DNA-response elements (TREs) in the proximal promoters of target genes as heterodimers with retinoid X receptors (RXRs) but can also regulate target genes via protein–protein interactions with heterologous transcription factors ( Baxter & Webb 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0440
Volume/Issue:
Volume 224: Issue 3
Free access
Jennifer J DuPont Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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Iris Z Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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suppression of the miR-155 transcription is unclear; however, the promoter has several binding sites for transcription factors, including NF-kB and AP-1 ( Onyeagucha et al. 2013 ), which are known to interact with the MR to regulate gene transcription

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0009
Volume/Issue:
Volume 234: Issue 1
Free access
Yun-Ju Chen Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Pei-Wen Hsiao Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Ming-Ting Lee Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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J Ian Mason Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Ferng-Chun Ke Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Jiuan-Jiuan Hwang Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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transduction activated in response to growth factors and is thought to contribute to many important cellular functions, including nutrient metabolism, cell growth, apoptosis, and modulating the activity of transcription factors ( Brazil et al. 2004 , Hanada

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0076
Volume/Issue:
Volume 192: Issue 2
Free access
Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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oestrogen – are predominantly mediated through two distinct ERs (ERα and ERβ) that share a common phylogenetic origin, conserved structural organization and similar mode of action (mainly as ligand-operated transcription factors) with the other members of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0003
Volume/Issue:
Volume 238: Issue 3
Open access