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Sarit Ben-Shmuel Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Eyal J Scheinman Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Rola Rashed Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Zila Shen Orr Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Emily J Gallagher Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Derek LeRoith Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel
Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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Ran Rostoker Clinical Research Institute at Rambam (CRIR), Division of Endocrinology, Diabetes and Metabolism Clinical Research Center of Excellence, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel

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mice. Cell culture Mvt-1 mouse mammary cancer cells were derived from MMTV-c-Myc/Vegf transgenic mice tumor explants, as previously described ( Pei et al . 2004 ). Cells were cultured in DMEM (Biological Industries, Beit Haemek, Israel) supplemented

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T Pasqua
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B Tota
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C Penna Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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A Corti Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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M C Cerra
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Y P Loh Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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T Angelone
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pathways . Endocrinology 154 1624 – 1635 . ( doi:10.1210/en.2012-2064 ) Penna C Perrelli MG Karam JP Angotti C Muscari C Montero-Menei CN Pagliaro P 2013b Pharmacologically active microcarriers influence VEGF-A effects on mesenchymal

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Mahendra Prasad Bhatt Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Yeon-Ju Lee Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Se-Hui Jung Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Yong Ho Kim SKKU Advanced Institute of Nanotechnology and Department of Chemistry, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea

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Jong Yun Hwang Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Eun-Taek Han Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Won Sun Park Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Seok-Ho Hong Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Young-Myeong Kim Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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Kwon-Soo Ha Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, Korea

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.1161/CIRCRESAHA.108.181644 ) Lim YC Bhatt MP Kwon MH Park D Lee S Choe J Hwang J Kim YM Ha KS 2014 Prevention of VEGF-mediated microvascular permeability by C-peptide in diabetic mice . Cardiovascular Research 101 155

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Lei Yu Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China

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Haoran Wang State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China

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Xiaoxue Han State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China

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Honghui Liu State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China

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Dalong Zhu Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China

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Wenhuan Feng Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China

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Jinhui Wu State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China

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Yan Bi Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China

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K Chan CW Mulligan KX Kuo D Yuan J , 2013 A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by vegf inhibition . Nature Medicine 19 1331 – 1337 . ( https://doi.org/10.1038/nm.3295 ) 10.1038/nm

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Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production . Cell 173 117 .e14 – 129.e14 . ( https://doi.org/10.1016/j.cell.2018.03.001 ) McQueen AE Koliwad SK Wang JC 2018 Fighting obesity by targeting factors regulating beige adipocytes

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Keisuke Ishizawa Pharmacology, Medical Pharmacology, Departments of

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Narantungalag Dorjsuren Pharmacology, Medical Pharmacology, Departments of

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Yuki Izawa-Ishizawa Pharmacology, Medical Pharmacology, Departments of

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Rika Sugimoto Pharmacology, Medical Pharmacology, Departments of

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Yasumasa Ikeda Pharmacology, Medical Pharmacology, Departments of

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Yoshitaka Kihira Pharmacology, Medical Pharmacology, Departments of

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Kazuyoshi Kawazoe Pharmacology, Medical Pharmacology, Departments of

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Shuhei Tomita Pharmacology, Medical Pharmacology, Departments of

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Koichiro Tsuchiya Pharmacology, Medical Pharmacology, Departments of

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Kazuo Minakuchi Pharmacology, Medical Pharmacology, Departments of

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Toshiaki Tamaki Pharmacology, Medical Pharmacology, Departments of

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475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration . Journal of Pharmacological Sciences 98 130 – 141 . Arita Y Kihara S Ouchi N Takahashi M Maeda K Miyagawa J Hotta K Shimomura I Nakamura

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Weiwei Qin Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Wenbao Lu Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Hongwei Li Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Xiaochen Yuan Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Bingwei Li Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Qiuju Zhang Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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Ruijuan Xiu Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, China

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, MMP-9, and VEGF . Journal of Environmental Pathology, Toxicology and Oncology 30 139 – 151 . Pustovrh MC Jawerbaum A Capobianco E White V Martinez N Lopez-Costa JJ Gonzalez E 2005 Oxidative stress promotes the increase of matrix

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E A Parker Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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A Hegde Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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M Buckley Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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K M Barnes Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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J Baron Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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O Nilsson Developmental Endocrinology Branch, National Institutes of Health, National Institute of Child Health and Human Development, Building 10/CRC, Rm 1-3330, MSC 1103, 10 Center drive, Bethesda, Maryland 20892, USA
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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, Werb Z & Ferrara N 1999 VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nature Medicine 5 623 –628. Gevers EF , Milne J, Robinson IC & Loveridge N 1996

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Marta Montolio Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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Montse Biarnés Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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Noèlia Téllez Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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Jessica Escoriza Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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Joan Soler Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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Eduard Montanya Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); Endocrine Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

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of human pancreatic islet transplantation. Transplantation 65 722 –727. Vasir B , Jonas J, Steil G, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S & Weir GC 2001 Gene expression of VEGF and its receptors Flk

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Tsuneo Kobayashi Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

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Takayuki Matsumoto Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

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Katsuo Kamata Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

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established STZ-induced diabetes. British Journal of Pharmacology 127 835 –842. Kobayashi T & Kamata K 2002 Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats. American

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