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Niels L Mulder Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Rick Havinga Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Joost Kluiver Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Albert K Groen Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Janine K Kruit Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Scheppke L Huang M Shields DJ Lindquist JN Lapinski PE , 2010 MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis . Nature Medicine 16 909 – 914 . ( https://doi.org/10.1038/nm.2186 ) 10

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Hongyu Su Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Xueyi Chen Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Yueming Zhang Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China
Department of Obstetrics and Gynecology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Linglu Qi Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Yun He Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Juanxiu Lv Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Yingying Zhang Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Xiang Li Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Jiaqi Tang Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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Zhice Xu Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China

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.2016 ) Williams JM Pearce WJ 2006 Age-dependent modulation of endothelium-dependent vasodilatation by chronic hypoxia in ovine cranial arteries . Journal of Applied Physiology 225 – 232 . ( https://doi.org/10.1152/japplphysiol.00221.2005 ) Wu C Li

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Gustavo W Fernandes
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Cintia B Ueta Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Tatiane L Fonseca Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Cecilia H A Gouveia Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Carmen L Lancellotti Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Patrícia C Brum Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Marcelo A Christoffolete Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Antonio C Bianco Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Miriam O Ribeiro Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Physiology. Endocrinology and Metabolism 285 E775 – E782 . ( doi:10.1152/ajpendo.00175.2003 ) Huang Y Kwok KH Chan NW Lau CW Chen ZY 1998 Role of endothelium and K + channels in dobutamine-induced relaxation in rat mesenteric artery

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Jeffrey Friedman Rockefeller University, Box 305, 1230 York Avenue, New York, New York 10065, USA

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questions remain unanswered including the aforementioned. How is leptin transported into the CNS? Previous studies suggested that leptin entered the brain by transport across the vascular endothelium ( Banks & Farrell 1999 , Banks & Farrell 2003 ). However

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Björn Åkerblom Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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Sebastian Barg Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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Gabriela Calounova Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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Dariush Mokhtari Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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Leif Jansson Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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Michael Welsh Department of Medical Cell Biology, Uppsala University, PO Box 571, Husargatan 3, 751 23 Uppsala, Sweden

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et al . 2009 ). As in liver and heart microvasculature, the islet endothelium exhibits aberrations. These show some similarities with those of the other organs, but differences are also noted. Whereas the islet endothelial cytoplasm was more

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Michael P Corcoran Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Mohsen Meydani Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Alice H Lichtenstein Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Ernst J Schaefer Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Alice Dillard Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Stefania Lamon-Fava Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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indicate that CRP may actively participate in plaque development by promoting endothelial dysfunction ( Bisoendial et al . 2007 ), monocyte adhesion to the endothelium ( Li et al . 2004 ), macrophage cholesterol accumulation ( Singh et al . 2008 ), and

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Rafaela Fadoni Alponti Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil
Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Patricia Lucio Alves Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Paulo Flavio Silveira Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Paschoalin T Curcio MF Borges RE Taha MO Fonseca FV Stern A Monteiro HP 2014 Endothelium-derived nitric oxide (NO) activates the NO-epidermal growth factor receptor-mediated signaling pathway in bradykinin-stimulated angiogenesis . Archives

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Diane Donegan Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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Laurie K Bale Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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Cheryl A Conover Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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, mesangial cells interact with other cells such as the podocyte, endothelium and inflammatory cells. Although no appreciable IGFs were detected in HMC-conditioned media, the presence and activation of the IGF1R indicate that HMCs are primed to respond to IGF1

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Janine Leckelt Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany

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Pedro Guimarães Department of Information Engineering, University of Padua, Padua, Italy

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Annett Kott Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany

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Alfredo Ruggeri Department of Information Engineering, University of Padua, Padua, Italy

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Oliver Stachs Department of Ophthalmology, University of Rostock, Rostock, Germany

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Simone Baltrusch Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany

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a wavelength of 1040 nm and, because of their strong auto-fluorescence, the corneal epithelium and endothelium were excited at 740 nm. Images were analyzed with FV30S (Olympus) and Imaris (Bitplane, Zurich, Switzerland). Statistical analysis

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Wenpeng Dong Dialysis Center, Daqing Oilfield General Hospital, Daqing, Heilongjiang, People’s Republic of China
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Xiuxia Liu Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Huan Zhang Operating theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Tie Li Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Xudong Chen Gastroenterology Department No. 1, Jilin Central General Hospital, Jilin, Jilin, People’s Republic of China

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Fuchun Wang Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Weixia Sun Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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. ( doi:10.1038/ki.2013.74 ) Pendyala S Moitra J Kalari S Kleeberger SR Zhao Y Reddy SP Garcia JG Natarajan V 2011 Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional

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