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the removal of bone by osteoclasts and the formation of new bone by osteoblasts. Up to 65% of osteoblasts that originate at the remodelling site die by apoptosis, or programmed cell death (PCD), a process common to several regenerating tissues ( Jilka
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contributing to the programming of adult reproductive function ( Stewart & Cygan 1980 , Clarkson et al. 2009 , Brock et al. 2011 , Kuiri-Hänninen et al. 2013 , Rey 2014 ). The ovary is already receptive to gonadotropins during the infantile period
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Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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rats after birth To determine whether the ovarian development abnormalities caused by PEE will persist after birth and have a programming effect, we observed the body weight of female offspring rats at different time points after birth. Compared with
Department of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Naples, Italy
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Department of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Naples, Italy
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Department of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Naples, Italy
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Department of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Naples, Italy
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survival preventing programmed cell death ( Matsui et al. 1991 , Pesce et al. 1993 , Hakovirta et al. 1999 , Yan et al. 2000 ). Endocrine and paracrine/autocrine factors also regulate germ cell proliferation: FSH stimulates spermatogonial
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The Florey Institute of Neuroscience and Mental Health, Microscopy Facility, Melbourne, Victoria, Australia
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Barwon Health Laboratory, Barwon Health, University Hospital, Geelong, Victoria, Australia
Institute for Physical and Mental Health and Clinical Transformation, School of Medicine, Deakin University, Geelong, Victoria, Australia
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ARC Centre of Excellence for Nanoscale Biophotonics, RMIT University, Melbourne, Victoria, Australia
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ovarian primordial follicle pool ( Sominsky et al. 2016 ). While these studies strongly implicate early life microglia in the perinatal programming of hypothalamic control of gonadotropin release and thereby ovarian health, it remains unclear whether
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foetal outcomes, both immediately at birth and during adulthood. Recent advances in the field have indicated that numerous adulthood diseases, including those characteristic of metabolic syndrome, could be programmed in utero in response to maternal
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Introduction There is considerable support for the hypothesis that events occurring in fetal life could have life-long consequences on the health of the adult ( Barker et al. 1989 ). Lucas (1991) defined programming as the
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. 2020 ). Academic and industrial GLP-1R agonist programs have since undertaken a robust, iterative approach to optimizing Ex-4-based compounds, including some that demonstrate substantial signaling bias. As mentioned previously, Phe1-Ex-4 exhibits
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be in the range of 1.8–2.0. About 10 ng of miR was converted to cDNA using TaqMan miRNA reverse transcription kit using RT primer specific for each miR. RT reaction was performed in a thermocycler (Applied Biosystems) using the program (16°C for 30
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obesity, cardiovascular disease and diabetes in adulthood ( Vanhala et al . 1998 , Ravelli et al . 2005 , Barker et al . 2007 ). This leads to the conclusion that adult diseases may originate during organ development and suggests that a programming of