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M Fraenkel Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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J Caloyeras Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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S-G Ren Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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S Melmed Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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estrogen receptors have increased adipose tissue, increased insulin resistance and impaired glucose tolerance ( Heine et al. 2000 ). The additional protection conferred by estradiol in our model could be due to decreased adipose tissue or its

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06656
Volume/Issue:
Volume 189: Issue 3
Free access
Sharon H Chou Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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Christos Mantzoros Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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eventually emerged as the predominant candidate linking adipose tissue, energy availability, and reproductive function ( Chan & Mantzoros 2005 , Mantzoros et al . 2011 ). Leptin is a hormone produced primarily in adipose tissue, and concentrations of leptin

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0245
Volume/Issue:
Volume 223: Issue 1
Free access
Anne-Marie O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Louise E Harris Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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George R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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to be up-regulated in adipose tissues by insulin ( Dray et al . 2010 ). Apelin APJ remained an orphan receptor until 1998 when Tatemoto et al . (1998) identified a 36-amino acid peptide termed apelin, for AP J e ndogenous li ga n d. Apelin gene

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0227
Volume/Issue:
Volume 219: Issue 1
Free access
Elena Conte Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Adele Romano Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Michela De Bellis Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Marialuisa de Ceglia Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Maria Rosaria Carratù Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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Silvana Gaetani Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Fatima Maqoud Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Domenico Tricarico Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Claudia Camerino Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy
Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy
Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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 = 24 ± 1°C) as previously shown ( Chevalier et al. 2015 , Camerino et al. 2017 , 2019 ). The involvement of Oxt in thermoregulation was confirmed by a recent study showing that Oxt expression in the hypothalamus and Oxtr in adipose tissue were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0346
Volume/Issue:
Volume 249: Issue 2
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Jessica C Hogan Department of Biological Sciences, 202 Life Sciences Building, Louisiana State University, Baton Rouge, Louisiana 70803, USA

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Jacqueline M Stephens Department of Biological Sciences, 202 Life Sciences Building, Louisiana State University, Baton Rouge, Louisiana 70803, USA

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), and promoting bone formation ( Dazai et al. 2000 ). LIF has also been demonstrated to have multiple effects on adipocytes and adipose tissue. Initially, LIF was characterized as an inducer of cachetic weight loss in mice engrafted with a melanoma

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05980
Volume/Issue:
Volume 185: Issue 3
Free access
María Sol Kruse Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina

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María Cristina Vega Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina

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Mariana Rey Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina

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Héctor Coirini Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina
Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina
Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, C1428ADN Ciudad Autónoma de Buenos Aires, Argentina

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that significant sex difference in glucose tolerance rates appears as the animals become older. Male rats gain body weight more rapidly than females, and adipose tissue is preferentially distributed in the abdominal or visceral region (male pattern of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0054
Volume/Issue:
Volume 222: Issue 1
Free access
Eun Jig Lee Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA

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J Larry Jameson Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA

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adipose tissue in GH deficient adults ( Hull & Harvey 2003 , Merriam et al. 2004 ). However, the inconvenience caused by daily injections and the occasional development of anti-GH antibodies has led to consideration of a gene therapy approach ( Ahangari

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06023
Volume/Issue:
Volume 185: Issue 3
Free access
Salla Nuutinen Research Center for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Liisa Ailanen Research Center for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Eriika Savontaus Research Center for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland

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Petteri Rinne Research Center for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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fat or lean mass were observed in male mice ( Fig. 1C , D and E ). In line with these results, epididymal or retroperitoneal white adipose tissue (WAT) weights were not different in male mice ( Table 1 ). In female MSH-OE mice, gonadal fat mass

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0636
Volume/Issue:
Volume 236: Issue 3
Free access
Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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nutrients absorbed after food consumption, metabolites produced by the liver and redirected to the peripheral tissues, gastrointestinal peptides, and cytokines derived from the immune system, bone, muscle, and adipose tissue ( Fig. 1 ). Figure 1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0066
Volume/Issue:
Volume 246: Issue 2
Free access
Wenjun Deng Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Mingyu Xu Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Rui Dong Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Yisha Yan Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Quan Jiang Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Introduction Irisin, a PGC1α-dependent myokine derived from the cleavage of FNDC5, exerts various metabolic effects across tissues through integrin αVβ5 activation ( Kim et al. 2018 ). In white adipose tissue, irisin induces browning and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0122
Volume/Issue:
Volume 262: Issue 3
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