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Shona H Wood Department of Arctic and Marine Biology, UiT – The Arctic University of Norway, Tromsø, Norway
Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, UK

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into constant LP, we can reveal the circannual rhythm and assess the known photoperiodic circuits ( Fig. 2 ). Here, both the melatonin signal and the local circadian clockwork in the PT does not change, continuing to reflect the prevailing photoperiod

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Ferran Jardí Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Michaël R Laurent Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Vanessa Dubois Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Nari Kim Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Rougin Khalil Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Brigitte Decallonne Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Dirk Vanderschueren Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Frank Claessens Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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males is primarily mediated by ERα, though this does not exclude the possibility that ERβ plays a role in modulating the circadian-rhythm patterns of activity, as shown for females ( Royston et al. 2014 ). ‘Non-classical’ ER knock-in (NERKI) mice

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Takahiro Nemoto Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Yoshihiko Kakinuma Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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, Indredavik et al . 2004 , Raikkonen et al . 2008 , Schendel & Bhasin 2008 ). These disorders are associated with abnormalities of the hypothalamic–pituitary–adrenal (HPA) axis such as disturbed circadian rhythm, impaired cortisol suppression by

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K Scrimgeour
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M J Gresham
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L R Giles Faculty of Veterinary Science, Department of Primary Industries, University of Sydney, Camden, New South Wales 2570, Australia

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P C Thomson
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P C Wynn
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R E Newman
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). La Fleur (2003) has postulated that glucose metabolism is regulated in a rhythmic fashion over a 24-h light/darkness cycle through the endogenous circadian oscillator located within the SCN and that this rhythm is independent of feeding activity

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Lieta Marinelli Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Erminio Trevisi Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Laura Da Dalt Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Mariacristina Merlo Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Giuseppe Bertoni Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Gianfranco Gabai Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Reproduction and Fertility 66 513 –518. Zhao Z-Y , Xie Y, Fu Y-R, Li Y-Y, Bogdan A & Touitou Y 2003 Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30 to 60

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Hiroharu Mifune Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Yusuke Sakai Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yukie Kawahara Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Kento Hara Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Takahiro Sato Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Yoshihiro Nishi Department of Physiology, Kurume University School of Medicine, Kurume, Japan

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Akinori Nishi Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Ryouichi Mitsuzono Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan

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Tatsuyuki Kakuma Bostatistics Center, Kurume University, Kurume, Japan

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Masayasu Kojima Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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often associated with physical inactivity and disrupted life rhythms, including binge and night eating ( Marcus & Wildes 2014 ), which makes the treatment of obesity more complicated and weight reduction less attainable. Although exercise is recommended

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Isao Tamura Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Hiroshi Tamura Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Mai Kawamoto-Jozaki Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yumiko Doi-Tanaka Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Haruka Takagi Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yuichiro Shirafuta Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yumiko Mihara Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Ryo Maekawa Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Toshiaki Taketani Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Shun Sato Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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. 2014 ). Therefore, it is important to control body weight in women throughout life. Melatonin (N-acetyl-5-methoxytryptamine) is a molecule secreted by the pineal gland in a circadian manner. In addition to regulating circadian rhythms, melatonin has a

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Arnaud Lacombe Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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Vincent Lelievre Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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Charles E Roselli Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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Jean-Marc Muller Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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James A Waschek Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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Eric Vilain Departments of Human Genetics, Pediatrics, and Urology, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095-7088, USA
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA

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demonstrated that the dark–light circadian rhythm is damaged in VIP null mice ( Colwell et al. 2003 ), suggesting that rhythmic secretion of gonadotropins might be perturbed in VIP KO mice. Altogether, these data strongly favor the idea that the lack of VIP

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Clive W Coen Reproductive Neurobiology, Division of Women's Health, School of Medicine, King's College London, London SE1 1UL, UK

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] are of importance in conditioning sexual periodicity. It is likely that the intrinsic sexual rhythm of many mammals is adjusted … by such ‘exteroceptive factors’ as Marshall termed them’ ( Harris 1955 ). The mechanisms by which the central nervous

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Julia N C Toews Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Geoffrey L Hammond Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Victor Viau Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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( Table 1 ). In humans, the plasma concentrations of CBG (~500 nM) and cortisol (~50–500 nM over the circadian rhythm) are similar between sexes at all ages ( Robinson et al. 1985 , Russell & Lightman 2019 ). During physical trauma in humans, plasma

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