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Lenka Maletínská Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic

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Andrea Popelová Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic

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Michal Bencze Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic
Institute of Physiology AS CR, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic
Institute of Physiology AS CR, Prague, Czech Republic

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XH Qiao F Yang W Qi JS 2014 Lixisenatide rescues spatial memory and synaptic plasticity from amyloid beta protein-induced impairments in rats . Neuroscience 277 6 – 13 . ( https://doi.org/10.1016/j.neuroscience.2014.02.022 ) 24583037 10

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Mathias V Schmidt Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Claudia Liebl Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Vera Sterlemann Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Karin Ganea Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Jakob Hartmann Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Daniela Harbich Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Stephanie Alam Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Marianne B Müller Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr. 2-10, 80804 Munich, Germany

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Palmiter RD 1997 Endocrine function of neuropeptide Y knockout mice . Regulatory Peptides 70 199 – 202 . Grove KL Allen S Grayson BE Smith MS 2003 Postnatal development of the hypothalamic neuropeptide Y system . Neuroscience 116 393 – 406

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Eriko Furube Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Tetsuya Mannari Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Shoko Morita Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Kazunori Nishikawa Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Ayaka Yoshida Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Masanobu Itoh Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Seiji Miyata Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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. 1985 Ben-Barak Y Russell JT Whitnall MH Ozato K Gainer H 1985 Neurophysin in the hypothalamo-neurohypophysial system. I. Production and characterization of monoclonal antibodies . Journal of Neuroscience 5 81 – 97 . Bozoyan et al

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Juan Bernal Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid, Madrid, Spain

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Beatriz Morte Center for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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Diego Diez Immunology Frontier Research Center, Osaka University, Osaka, Japan

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://www.ncbi.nlm.nih.gov/books/NBK234146/ ) Alvarez-Dolado M Ruiz M Del Rio JA Alcantara S Burgaya F Sheldon M Nakajima K Bernal J Howell BW Curran T 1999 Thyroid hormone regulates reelin and dab1 expression during brain development . Journal of Neuroscience 19 6979

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Dawn E W Livingstone Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Emma M Di Rollo Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Chenjing Yang Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Lucy E Codrington Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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John A Mathews Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Madina Kara Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Katherine A Hughes Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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transgenic mice: evidence of a direct mechanism mediated by proximal 5′ flanking sequence . Neuroscience 78 1177 – 1185 . ( doi:10.1016/S0306-4522(96)00603-3 ) Carter RN Paterson JM Tworowska U Stenvers DJ Mullins JJ Seckl JR Holmes MC

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Pauline Campos College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK

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Jamie J Walker College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK
EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK

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Patrice Mollard IGF, University of Montpellier, CNRS, INSERM, Montpellier, France

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interpret without appropriate tools. Nevertheless, technological developments in genetics and systems neuroscience have enabled specific neurons to be manipulated in vivo . Chemogenetics and optogenetics ( Fenno et al. 2011 ) tools have made it possible

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Eugen Brailoiu Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Siok L Dun Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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G Cristina Brailoiu Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Keisuke Mizuo Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Larry A Sklar Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Tudor I Oprea Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Eric R Prossnitz Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Nae J Dun Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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& Ball GF 2006 Is brain estradiol a hormone or a neurotransmitter? Trends in Neuroscience 29 241 –249. Bologa CG , Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE

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Giulia Baldini Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Kevin D Phelan Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Castrogiovanni D Schioth HB Perello M Raingo J 2014 Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons . European Journal of Neuroscience 40 2755 – 2765 . ( https://doi.org/10.1111/ejn.12650 ) 10

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Anthony H Tsang Medical Department I, University of Lübeck, Lübeck, Germany

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Mariana Astiz Medical Department I, University of Lübeck, Lübeck, Germany

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Maureen Friedrichs Medical Department I, University of Lübeck, Lübeck, Germany

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Henrik Oster Medical Department I, University of Lübeck, Lübeck, Germany

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. ( doi:10.1371/journal.pone.0037150 ) Bechtold DA Loudon AS 2013 Hypothalamic clocks and rhythms in feeding behaviour . Trends in Neurosciences 36 74 – 82 . ( doi:10.1016/j.tins.2012.12.007 ) Begg DP Woods SC 2013 The

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Belkis Gizem Uzturk Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology

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Shan-xue Jin Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology

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Beverly Rubin Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology
Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology

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Christopher Bartolome Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology

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Larry A Feig Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology
Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology

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sponsor: National Institutes of Health; grant number: RO1 MH083324 (to L A F) and grant sponsor: Tufts Center for Neuroscience Research; grant number: P30 NS047243. References Andersen SL Teicher MH 2008 Stress, sensitive periods and maturational

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