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J Bryce Ortiz Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA

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Sebastian Tellez Arizona State University, School of Life Sciences, Tempe, Arizona, USA

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Giri Rampal Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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Grant S Mannino Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Nicole Couillard Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Matias Mendez Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Tabitha R F Green Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Sean M Murphy Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Rachel K Rowe Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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>20% of their body weight or had unmanageable pain. No rats in this study met those criteria, so none were excluded. Predetermined inclusion criteria included a righting reflex time >120 s and no breach of the dura. All plasma samples and slides were

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Sebastian R Vanin Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Kendrick Lee Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Mina Nashed Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Brennan Tse Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Mohammed Sarikahya Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Sukham Brar Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Gregg Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Amica-Mariae Lucas Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Thane Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Steven R Laviolette Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Edith J Arany Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Daniel B Hardy Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
The Lawson Health Research Institute and the Children's Health Research Institute, London, Ontario, Canada

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D Callan J Orhurhu V Simopoulos T Viswanath O Kaye AD Kaye RJ , et al. 2020 Considerations and implications of cannabidiol use during pregnancy . Current Pain and Headache Reports 24 38 . ( https://doi.org/10.1007/s11916-020-00872-w

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Emre Murat Altinkilic Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of BioMedical Research, University of Bern, Bern, Switzerland

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Philipp Augsburger Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of BioMedical Research, University of Bern, Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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Amit V Pandey Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of BioMedical Research, University of Bern, Bern, Switzerland

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Christa E Flück Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of BioMedical Research, University of Bern, Bern, Switzerland

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. European Journal of Endocrinology 177 187 – 194 . ( https://doi.org/10.1530/EJE-17-0027 ) Arakane F Sugawara T Nishino H Liu Z Holt JA Pain D Stocco DM Miller WL & Strauss JF 3rd 1996 Steroidogenic acute regulatory protein (StAR

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Marina Ercilia Dasso Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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Cecilia Lucia Centola Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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María Noel Galardo Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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Silvina Beatriz Meroni Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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María Fernanda Riera Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling . Acta Biochimica et Biophysica Sinica 52 612 – 619 . ( https://doi.org/10.1093/abbs/gmaa038 ) Faure M Guibert E Alves S Pain B Ramé C Dupont J Brillard JP & ent P 2016 The insulin

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Cristina Capatina Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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John A H Wass Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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, osteoarthritis – 24% Chronic pain Hearing loss Myopathy Decreased bone quality, vertebral fractures Cardiovascular Arterial hypertension – 40% Cardiomyopathy Ventricular hypertrophy Arrythmias Congestive heart failure Metabolic Diabetes mellitus Glucose

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Daniel Cuevas-Ramos Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA
Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Maria Fleseriu Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

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spironolactone  Etomidate Bolus 0.03 mg/kg i.v.; followed by 0.1–0.3 mg/kg per h Nephrotoxicity, sedation, pain at the infusion site, anaphylactic reactions, coughing, hiccups, nausea, vomiting, and myoclonus  LCI699 4–100 mg/day (investigational drug

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Barbara J Clark Department of Biochemistry and Molecular Biology, and the Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA

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Brown: from cholesterol homeostasis to new paradigms in membrane biology . Trends in Cell Biology 13 534 – 539 . doi:10.1016/j.tcb.2003.08.007 . Arakane F Sugawara T Nishino H Liu Z Holt JA Pain D Stocco DM Miller WL Strauss JF

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Giulia Baldini Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Kevin D Phelan Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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projections to the PBN inhibit inflammatory pain by signaling through NPY ( Alhadeff et al. 2018 ). During satiety, activation of AgRP neurons mimics hunger by a pathway to the insular cortex via the paraventricular thalamus (PVT) and basolateral amygdala

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Patrik Šimják Department of Gynaecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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Anna Cinkajzlová Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Kateřina Anderlová Department of Gynaecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
3rd Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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Antonín Pařízek Department of Gynaecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Michal Kršek 3rd Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
2nd Internal Department, 3rd Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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. ( https://doi.org/10.1002/path.4394 ) 28406695 Sylven C 1993 Mechanisms of pain in angina pectoris--a critical review of the adenosine hypothesis . Cardiovascular Drugs and Therapy 7 745 – 759 . ( https://doi.org/10.1007/BF00878926 ) 10

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Elias Rawish Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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Laura Nickel Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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Franziska Schuster Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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Ines Stölting Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Alex Frydrychowicz Department of Radiology and Nuclear Medicine, University-Hospital Schleswig Holstein and University of Lübeck, Lübeck, Germany

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Kathrin Saar Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch, Germany
DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany

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Norbert Hübner Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch, Germany
DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany

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Alaa Othman CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany
Institute for Clinical Chemistry, University Hospital Zürich, Zurich, Switzerland

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Lars Kuerschner Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany

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Walter Raasch Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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.06.014 ) Li T Chen X Zhang C Zhang Y Yao W 2019 An update on reactive astrocytes in chronic pain . Journal of Neuroinflammation 140 . ( https://doi.org/10.1186/s12974-019-1524-2 ) Miesel A Muller-Fielitz H Johren O Vogt FM Raasch W

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