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Masami Hayashi
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Masahiro Sakata
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Takashi Takeda
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Yoko Okamoto
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Kenjiro Sawada
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Akiko Kimura
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Ryoko Minekawa
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Masahiro Tahara
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Keiichi Tasaka
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Yuji Murata
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response to oxygen deficiency in this organ. However, the precise mechanism regulating GLUT1 expression during placentation has not been fully clarified. Heterodimeric hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that mediates

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05599
Volume/Issue:
Volume 183: Issue 1
Free access
Jia Fang Wang Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of

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David J Hill Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of

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depends on the expression of key transcription factors such as PDX-1 and PTF1α within the ductal cells ( Murtaugh 2007 ). PDX-1 is also required in the mature β-cell where it trans-activates the insulin and GLUT2 gene promoters. Other transcription factors

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0296
Volume/Issue:
Volume 201: Issue 1
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A McMaster Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular

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T Chambers Medicine, Faculty of Life Sciences, Centre for Molecular

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Q-J Meng Medicine, Faculty of Life Sciences, Centre for Molecular

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S Grundy Medicine, Faculty of Life Sciences, Centre for Molecular

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A S I Loudon Medicine, Faculty of Life Sciences, Centre for Molecular

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R Donn Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular

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D W Ray Medicine, Faculty of Life Sciences, Centre for Molecular

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translocating to the nucleus, and interacting with other transcription factors and transcriptional modulators ( Chen et al . 2001 , Stevens et al . 2003 , Garside et al . 2004 , O'Malley 2005 , McMaster & Ray 2007 ). In vivo target cells are subject to

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0639
Volume/Issue:
Volume 197: Issue 2
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Miroslav Adzic
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Jelena Djordjevic
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Ana Djordjevic
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Ana Niciforovic
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Constantinos Demonacos Laboratory of Molecular Biology and Endocrinology, School of Pharmacy, Faculty of Life Sciences, VINCA Institute of Nuclear Sciences, PO Box-522-MBE090, 11001 Belgrade, Serbia

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Marija Radojcic
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Marija Krstic-Demonacos Laboratory of Molecular Biology and Endocrinology, School of Pharmacy, Faculty of Life Sciences, VINCA Institute of Nuclear Sciences, PO Box-522-MBE090, 11001 Belgrade, Serbia

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-releasing hormone (CRH), brain-derived neurotropic factor (BDNF), and cytokines ( Goujon et al . 1997 , Schulkin et al . 1998 , Morsink et al . 2006 , Schulte-Herbruggen et al . 2006 ). The GR transcriptional activity is dependent on the cell type, the

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DOI:
https://doi.org/10.1677/JOE-08-0509
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Volume 202: Issue 1
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Gonzalo Alba Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Consuelo Santa-María Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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María Edith Reyes-Quiroz Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Rajaa El Bekay Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Isabel Geniz Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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José Martín-Nieto Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Elizabeth Pintado Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Francisco Sobrino Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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. Although high concentrations of ROS are catatonic, they are now known to function as signal transducing molecules at lower concentrations, modulating indirectly the activity of many enzymes and transcription factors. Classical regulation of the activity of

Article Type:
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DOI:
https://doi.org/10.1530/JOE-12-0106
Volume/Issue:
Volume 214: Issue 3
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Myat Theingi Swe Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Physiology, University of Medicine 2, Yangon, Myanmar

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Laongdao Thongnak Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Krit Jaikumkao Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Anchalee Pongchaidecha Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Varanuj Chatsudthipong Research Center of Transport Protein for Medical Innovation, Faculty of Science, Mahidol University, Bangkok, Thailand

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Anusorn Lungkaphin Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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renal cortical tissue in HF rats was attenuated by dapagliflozin and metformin administration ( P  < 0.05) ( Fig. 1I and J ). The effect of dapagliflozin on renal gluconeogenic enzyme expression might be mediated through transcription factors p

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0480
Volume/Issue:
Volume 245: Issue 2
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Yujiao Dai School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Peng Hao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhimei Sun School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhiyi Guo School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Hong Xu School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Lihui Xue Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Hongyu Song Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Yida Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Shuang Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Mingming Gao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Teng Si School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Yuxin Zhang School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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Yajuan Qi School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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potentially reverse hepatic fibrosis ( Mannaerts et al. 2015 ). As a coactivator of transcription factors, YAP promotes cell proliferation and inhibits apoptosis through the interaction between its transcriptional coactivator activity and TEAD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0561
Volume/Issue:
Volume 249: Issue 2
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Cyril S Anyetei-Anum Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Vincent R Roggero Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Lizabeth A Allison Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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-dependent transcription factors. By modulating the transcription of target genes in response to ligand, TRs play key physiological roles in the regulation of many aspects of development, growth and metabolism, including the regulation of mitochondrial activity ( Flamant

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0708
Volume/Issue:
Volume 237: Issue 1
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Ken Takao Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Katsumi Iizuka Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yanyan Liu Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Teruaki Sakurai Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Sodai Kubota Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Saki Kubota-Okamoto Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Toshinori Imaizumi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yoshihiro Takahashi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yermek Rakhat Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Satoko Komori Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tokuyuki Hirose Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Kenta Nonomura Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Takehiro Kato Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masami Mizuno Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tetsuya Suwa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yukio Horikawa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masakatsu Sone Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

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Daisuke Yabe Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan
Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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glucose levels were similar to those of WT mice (113.16 ± 14.03 (WT) vs 125.33 ± 13.19 ( Chrebp −/− ) , respectively). mRNA expression of Srebf2, a key transcription factor controlling synthesis and uptake of cholesterol and their target genes, was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0442
Volume/Issue:
Volume 248: Issue 3
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Ljupka Gligorovska Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Biljana Bursać Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Sanja Kovačević Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Nataša Veličković Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Gordana Matić Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Ana Djordjevic Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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number of insulin-regulated transcriptional factors are engaged in lipid metabolism and adipose tissue development. The examples are sterol regulatory element-binding protein 1c (SREBP1c), responsible for triglyceride biosynthesis, as well as PPARG

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0333
Volume/Issue:
Volume 240: Issue 2
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