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Ronald J van der Sluis Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Miranda Van Eck Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Menno Hoekstra Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Experiments of Leiden University. Adrenal transplant glucocorticoid function tests Ad libitum -fed adrenal transplanted mice were bled at 0900 h via tail cut to measure basal plasma corticosterone levels on the lowest point of the circadian rhythm

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Da-Long Ren Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ai-Ai Sun Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ya-Juan Li Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Min Chen Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Shu-Chao Ge Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Bing Hu Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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243 – S243 . Scheff JD Calvano SE Lowry SF Androulakis IP 2010 Modeling the influence of circadian rhythms on the acute inflammatory response . Journal of Theoretical Biology 264 1068 – 1076 . ( doi:10.1016/j.jtbi.2010

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Takeshi Iwasa Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Toshiya Matsuzaki Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Masahiro Murakami Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Riyo Kinouchi Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Ganbat Gereltsetseg Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Shinobu Fujisawa Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Akira Kuwahara Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Toshiyuki Yasui Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Minoru Irahara Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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any specific grant from any funding agency in the public, commercial or not-for-profit sector. References Ahima RS Prabakaran D Flier JS 1998 Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding . Journal of

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Dawn E W Livingstone Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Sarah L Grassick Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Gillian L Currie Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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serotonin and corticosteroid receptor gene expression in the rat hippocampus with circadian rhythm and stress . Molecular Brain Research 28 186 – 192 . Horton R Pasupuletti V Antonipillai I 1993 Androgen induction of steroid 5α-reductase may

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Helge Müller Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Juliane Kröger Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Olaf Jöhren Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Silke Szymczak Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Michael Bader Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Peter Dominiak Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Walter Raasch Institute of Experimental and Clinical Pharmacology and Toxicology, Institute of Medical Biometry and Statistics, Max-Delbrück-Center for Molecular Medicine (MDC), University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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fed high sodium chloride diet from weaning . Journal of the Autonomic Nervous System 72 16 – 23 . Campos LA Plehm R Cipolla-Neto J Bader M Baltatu OC 2006 Altered circadian rhythm reentrainment to light phase shifts in rats with low

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Caitlin S Wyrwoll School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network

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temperature ( Ravanelli et al. 2019 , Smallcombe et al. 2021 ). However, prolonged high ambient temperature (including at night which will disrupt normal circadian rhythm), the overlay of prolonged physical activity, and climatic factors other than

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A Santillo Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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L Burrone Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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S Falvo Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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R Senese Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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A Lanni Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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G Chieffi Baccari Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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a target for TH ( Delgado et al . 1988 , Osuna et al . 1990 ). Following thyroidectomy, the activity of 5′D in rat HG increases and exhibits a marked circadian rhythm ( Guerrero et al . 1987 ). Because the physiological effects of TH are exerted

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Lieta Marinelli Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Erminio Trevisi Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Laura Da Dalt Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Mariacristina Merlo Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Giuseppe Bertoni Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Gianfranco Gabai Dipartimento di Scienze Sperimentali Veterinarie, Università di Padova, viale dell’Università, 16, Agripolis 35020 Legnaro (PD), Italy
Istituto di Zootecnica, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy

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Reproduction and Fertility 66 513 –518. Zhao Z-Y , Xie Y, Fu Y-R, Li Y-Y, Bogdan A & Touitou Y 2003 Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30 to 60

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Ruben Nogueiras Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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Sulay Tovar Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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Sharon E Mitchell Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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Perry Barrett Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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D Vernon Rayner Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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Carlos Dieguez Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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Lynda M Williams Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK

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hypothalamus ( Graham et al. 2003 ). These nuclei are important in controlling circadian rhythms, appetite and energy balance ( Takahashi & Zatz 1982 , Williams et al. 2001 ). In contrast, NMU expression in the rat is limited to the SCN, relatively few

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Sharon E Mitchell Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Ruben Nogueiras Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Kellie Rance Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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D Vernon Rayner Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Sharon Wood Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Carlos Dieguez Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Lynda M Williams Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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rapidly after feeding ( Lee et al. 2002 ). However ghrelin in the hypothalamus is thought to link circadian rhythms and feeding activity ( Cowley et al. 2003 ). To determine if control mechanisms of energy balance may differ between the Lou

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