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Irving Salinas Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Physiology, Michigan State University, East Lansing, Michigan, USA

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Niharika Sinha Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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Aritro Sen Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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for steroids to coordinate gene regulation apart from the established pathways. Steroid receptors recruit several epigenetic modulators as an integral part of its transcription machinery and this has been extensively studied across species and cells

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0578
Volume/Issue:
Volume 249: Issue 3
Free access
Laura M Clart Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA

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Rebecca J Welly Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA

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Eric D Queathem Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA

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R Scott Rector Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
Internal Medicine-Division of Gastroenterology and Hepatology, University of Missouri System, Columbia, Missouri, USA
Research Service, Truman VA Memorial Hospital, Columbia, Missouri, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri System System, Columbia, Missouri, USA

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Christopher P Baines Department of Biomedical Sciences, University of Missouri System, Columbia, Missouri, USA

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Jill A Kanaley Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA

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Dennis B Lubahn Department of Biochemistry, University of Missouri System, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA

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binding of E 2 to receptors located on cell membranes, in the cytoplasm, or mitochondria, leading to the activation of signal transduction pathways. These pathways may indirectly also affect the gene regulation via their activation of other transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0009
Volume/Issue:
Volume 249: Issue 3
Restricted access
Anna E Bollag Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Tianyang Guo Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Vivek Choudhary Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Xunsheng Chen Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Qing Zhong Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Mohamed E Awad Department of Oral Biology, Dental College of Georgia at Augusta University, Augusta, Georgia, USA

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Mohammed Elsalanty Department of Oral Biology, Dental College of Georgia at Augusta University, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Wendy B Bollag Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

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be used as a drug to minimize bone loss as a promising alternative to oral antioxidant supplements. MMF activates endogenous antoxidant pathways like HO-1 and NRF2, which allow the body to modulate levels of ROS with innate gene regulation and protein

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0691
Volume/Issue:
Volume 243: Issue 1
Free access
Ying Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Nan Meng Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haili Bao Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Yufei Jiang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Ningjie Yang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Kejia Wu Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Jinxiang Wu Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haibin Wang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Shuangbo Kong Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Yuanzhen Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Ballare C Castellano G Gaveglia L Althammer S Gonzalez-Vallinas J Eyras E Le Dily F Zaurin R Soronellas D Vicent GP , et al . 2013 Nucleosome-driven transcription factor binding and gene regulation . Molecular Cell 67 – 79

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0284
Volume/Issue:
Volume 243: Issue 3
Restricted access
Itaru Minagawa Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan
Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Dai Sagata Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Ali Mohammed Pitia Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan
Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Hiroshi Kohriki Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Masatoshi Shibata Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Hiroshi Sasada Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Yoshihisa Hasegawa Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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Tetsuya Kohsaka Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan
Laboratory of Animal Reproduction and Physiology, Division of Animal Resource Production, Shizuoka Swine and Poultry Experimental Station, Laboratory of Animal Reproduction, School of Veterinary Medicine, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs . Biology of Reproduction 77 671 – 680 . ( doi:10.1095/biolreprod.107.060442 ) Ferlin A Garolla A Rigon F Caldogno LR Lenzi A Foresta C 2006 Changes in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0430
Volume/Issue:
Volume 220: Issue 3
Free access
Gabriel Forn-Cuní Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Monica Varela Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Conrado M Fernández-Rodríguez Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Antonio Figueras Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Beatriz Novoa Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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immunological response to a bacterial stimulus, cytokine signaling, and the regulation of apoptosis. Although the majority of the gene regulation following LPS treatment was inhibitory, the genes with the greatest alterations were primarily upregulated, with nr

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0398
Volume/Issue:
Volume 224: Issue 2
Free access
William Zawatski Pediatric Endocrine Division, Department of Pediatrics

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Mary M Lee
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dysfunction across the life cycle . Reviews in Endocrine & Metabolic Disorders 8 143 – 159 . ( doi:10.1007/s11154-007-9048-y ) Dolinoy DC Weidman JR Jirtle RL 2007 Epigenetic gene regulation: linking early developmental environment to adult

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0449
Volume/Issue:
Volume 218: Issue 2
Free access
Takehiro Tsukada Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan

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Morio Azuma Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan

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Kotaro Horiguchi Laboratory of Anatomy and Cell Biology, Department of Health Sciences, Kyorin University, Tokyo, Japan

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Ken Fujiwara Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan

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Tom Kouki Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan

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Motoshi Kikuchi Laboratory of Natural History, Jichi Medical University School of Medicine, Tochigi, Japan

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Takashi Yashiro Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan

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completely blocked by SB431542, a TGFβ receptor I inhibitor ( Fig. 7A and C ). These results suggest that canonical TGFβ signals in pericytes are associated with collagen gene regulation. We also showed that SB431542 significantly reduced type III collagen

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0033
Volume/Issue:
Volume 229: Issue 2
Free access
Jun-Ping Wen Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China
Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Chune Liu Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Wen-Kai Bi Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Ya-Ting Hu Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Qingshi Chen Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Huibing Huang Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Ji-Xing Liang Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Lian-Tao Li Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Li-Xiang Lin Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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Gang Chen Department of Endocrinology, Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China

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binding to GC-rich elements in response to physiological and pathological stimuli, and it can either activate or repress gene transcription. Previous studies have shown that the mechanism of its gene regulation partially lies in the translocation of SP1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0054
Volume/Issue:
Volume 214: Issue 2
Free access
Amelia J Brennan CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Julie A Sharp CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Elie Khalil CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Matthew R Digby CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Sonia L Mailer CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Christophe M Lefèvre CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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Kevin R Nicholas CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Melbourne, Victoria 3010, Australia

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proportion of apoptotic cells than explanted tissue and shows complete disorganisation and collapse of the mammary alveoli. The difference in morphology and gene regulation suggests that the occurrence of apoptotic mammary epithelial cells in mammary explants

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0537
Volume/Issue:
Volume 196: Issue 3
Free access