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Vicki E Smith School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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Jayne A Franklyn School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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Christopher J McCabe School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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: links to integrins and transcription factors . Trends in Biochemical Science 24 261 – 263 doi:10.1016/S0968-0004(99)01416-4 . Chien W Pei L 2000 A novel binding factor facilitates nuclear translocation and transcriptional activation function

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0064
Volume/Issue:
Volume 210: Issue 2
Free access
O A Sukocheva Division of Human Immunology, Signal Transduction Laboratory, Hanson Institute for Cancer Research, IMVS, Frome Road, Adelaide, South Australia 5000, Australia
Department of Biometry and Statistics, School of Public Health, University at Albany, SUNY, One University Place, Rensselaer, New York 12144, USA

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D O Carpenter Division of Human Immunology, Signal Transduction Laboratory, Hanson Institute for Cancer Research, IMVS, Frome Road, Adelaide, South Australia 5000, Australia
Department of Biometry and Statistics, School of Public Health, University at Albany, SUNY, One University Place, Rensselaer, New York 12144, USA

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the functions of THs were mediated by the c-erbA proto-oncogenes – THs nuclear receptors, members of the steroid/thyroid hormone nuclear receptor subfamily that also function as ligand-modulated transcription factors ( Yen 2001 ). Beyond the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07061
Volume/Issue:
Volume 191: Issue 2
Free access
Qinkai Li Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China
Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China
Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Weidong Yin Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Manbo Cai Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Yi Liu Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Hongjie Hou Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Qingyun Shen Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Chi Zhang Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Junxia Xiao Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Xiaobo Hu Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Qishisan Wu Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Makoto Funaki Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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Yutaka Nakaya Key Laboratory for Atherosclerology of Hunan Province, Department of Nutrition and Metabolism, Clinical Research Center for Diabetes, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People's Republic of China

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† P <0.01 versus control group; NS, no statistical significance. The expression of hepatic CYP7A1 is regulated by various factors ( Lu et al . 2000 ). Among them, we were especially interested in STAT5, a member of the STAT family of transcriptional

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0278
Volume/Issue:
Volume 204: Issue 1
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Jennifer A Evans Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA

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transcription and negative elements that repress transcription on a daily basis. The positive elements are the transcription factors CLOCK and BMAL1, whereas the negative elements are PERIOD and CRYTOCHROME proteins. Daily transcription is initiated when CLOCK

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0054
Volume/Issue:
Volume 230: Issue 1
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Gregory S Y Ong Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia
Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
Department of General Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

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Timothy J Cole Department of Biochemistry, Monash University, Clayton, Victoria, Australia

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Gregory H Tesch Department of Medicine, Monash University, Clayton, Victoria, Australia
Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia

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James Morgan Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia

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Jennifer K Dowling Hudson Institute of Medical Research, Clayton, Victoria, Australia
Royal College of Surgeons in Ireland, Dublin, Ireland

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Ashley Mansell Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia

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Morag J Young Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia

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, Gilz and Arg1 ), co-stimulation of the iBMDMs with PMA was required for aldosterone-mediated transcription of common regulators of inflammation ( Il1b , Il6 , Il10 and Il33 ). Several mechanisms may explain these data. The MR may be a co-factor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0161
Volume/Issue:
Volume 246: Issue 2
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Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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glucocorticoid receptor is a ligand-dependent transcription factor that mediates the diverse actions of glucocorticoids in nearly all tissues due to its ubiquitous expression in nucleated cells. The GR belongs to the nuclear receptor subfamily and has four

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-23-0399
Volume/Issue:
Volume 261: Issue 2
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Ernest Sargsyan
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Henrik Ortsäter Department of Medical Cell Biology, Department of Clinical Science and Education, Uppsala University, SE-75123, Uppsala, Sweden

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Kristofer Thorn
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Peter Bergsten
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transcriptional activation of chaperone proteins ( Lee et al . 2002 ). No induction of ATF6 cleavage was observed in the lipotoxic islets, INS-1E or MIN6 cells cultured in the absence or presence of diazoxide (data not shown). In support of the ATF6 pathway not

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0251
Volume/Issue:
Volume 199: Issue 1
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Melody L Allensworth-James Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Angela Odle Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Anessa Haney Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Melanie MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Angus MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Gwen Childs Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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and proliferation of the individual endocrine cell populations ( Rizzoti 2015 ). The earliest exclusive pituitary marker is PROP1 , a paired homeodomain transcription factor, which is expressed at embryonic day 10 (E10) in the mouse. SOX2- expressing

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0238
Volume/Issue:
Volume 238: Issue 3
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Gurvinder Kenth Division of Experimental Medicine, Department of Pediatrics, McGill University, Montreal, Quebec, Canada

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Jennifer A Manalo Mergelas Division of Experimental Medicine, Department of Pediatrics, McGill University, Montreal, Quebec, Canada

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Cynthia Gates Goodyer Division of Experimental Medicine, Department of Pediatrics, McGill University, Montreal, Quebec, Canada
Division of Experimental Medicine, Department of Pediatrics, McGill University, Montreal, Quebec, Canada

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intracellular signaling and adaptor proteins ( Fig. 1 ; Argetsinger et al . 1993 , Carter-Su et al . 1996 , Herrington & Carter-Su 2001 , Piwien-Pilipuk et al . 2002 , Lanning & Carter-Su 2006 , Brooks et al . 2008 ). The major GHR signaling factors in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0648
Volume/Issue:
Volume 198: Issue 1
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Yoko Yagishita Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Akira Uruno Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

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Dionysios V Chartoumpekis Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Thomas W Kensler Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Masayuki Yamamoto Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

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attractive means of preventing and/or treating type 1 diabetes. Identifying novel targets that protect β-cells from damage related to type 1 diabetes is an important goal, and searches for such targets have been widely conducted. The transcription factor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0355
Volume/Issue:
Volume 240: Issue 3
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