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Jodi F Evans Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA
Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Shahidul Islam Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Yoshihiro Urade Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Naomi Eguchi Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Louis Ragolia Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA
Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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is found in the vascular endothelium ( Taba et al . 2000 ) as well as adipose tissue ( Quinkler et al . 2006 , Fujimori et al . 2007 ). Its role in the vasculature is thought to be a protective one, where its downstream prostaglandin (PGD 2 ) and

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Michelle Keramidas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Caroline Faudot Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Agnès Cibiel Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Jean-Jacques Feige Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Michaël Thomas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Zhang Z Dillard-Telm L Frantz G Rangell L DeGuzman L Keller GA 2001 Identification of an angiogenic mitogen selective for endocrine gland endothelium . Nature 412 877 – 884 . LeCouter J Lin R Frantz G Zhang Z Hillan K Ferrara N

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Zhenhua Li
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Tao Zhang Department of Cardiology, Department of Orthopedic, Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and Function Research, Ministry of Education and Ministry of Health, Jinan 250012, China

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Hongyan Dai Department of Cardiology, Department of Orthopedic, Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and Function Research, Ministry of Education and Ministry of Health, Jinan 250012, China

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Guanghui Liu
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Haibin Wang
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Yingying Sun
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Yun Zhang
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Zhiming Ge
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myocardium, the tissue sections were labeled with an in situ TUNEL assay. Apoptosis was observed in both the cardiomyocyte and endothelium of the diabetic heart ( Fig. 3 A). Estimation of cardiac apoptosis revealed a nearly sevenfold increase in TUNEL

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Alessia Sagazio
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Xiao Xiao Division of Endocrinology, Division of Molecular Pharmaceutics, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street #333, Baltimore, Maryland 21287, USA

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Zhong Wang Division of Endocrinology, Division of Molecular Pharmaceutics, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street #333, Baltimore, Maryland 21287, USA

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Marco Martari
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Roberto Salvatori
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. 2005 ), hemophilia ( Arruda et al . 2005 ), loss of corneal endothelium ( Lai et al . 2005 ), and cerebral ischemia ( Tsai et al . 2002 ), with possible important future applications in humans. We have investigated whether such a new delivery system

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Fang Xiao School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

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John R Puddefoot School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

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Stewart Barker School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

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Gavin P Vinson School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

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– 32 . Lemos VS Cortes SF Silva DM Campagnole-Santos MJ Santos RA 2002 Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mRen-2 transgenic rats . British Journal of

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Joyce Wang
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Qing Qiu Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Maliha Haider Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Michael Bell Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Andrée Gruslin Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6
Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Julian K Christians
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of spongiotrophoblast, involved in the invasion of the decidua by fetal tissue ( Adamson et al . 2002 ). The substrate of PAPPA2, IGFBP5, is expressed in some maternal components of the mouse placenta, including endothelium of maternal blood vessels

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Martina Böttner Department of Clinical and Experimental Endocrinology, Department of Anatomy, University of Göttingen, Robert-Koch-Strasse 40, D-37099 Göttingen, Germany

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Julie Christoffel
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Wolfgang Wuttke
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synthesis of cell membranes, bile acids, and hormones. Low-density lipoproteins (LDLs) are the principal means by which cholesterol is transported from the liver to peripheral tissues. Oxidized LDL, however, can damage the arterial endothelium and is more

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A Cremades
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C Ruzafa
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F Monserrat
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A J López-Contreras
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R Peñafiel
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189 –197. Pieper GM & Dondlinger LA 1997 Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. Journal of

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Dae Ryong Cha
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Young Sun Kang
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Sang Youb Han
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Yi Hwa Jee
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Kum Hyun Han
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Jee Young Han
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Young Sik Kim
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Nan Hee Kim
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Z, Zollman F, Passeri J & Lekutat C 1997 Vascular endothelial growth factor/vascular permeability factor augment nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95 1030 –1037

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N Grion Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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E M Repetto Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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Y Pomeraniec Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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C Martinez Calejman Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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F Astort Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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R Sanchez Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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O P Pignataro Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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P Arias Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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C B Cymeryng Departmento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina
IBYME–CONICET Buenos Aires, C1428ADN, Argentina. Departamento de Química Biológica, Facultad de Ciencas Exactas y Naturales, Buenos Aires C1428EGA, Argentina
Departmento de Fistologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 5°, Buenos Aires C1121ABG, Argentina

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been associated with three NO synthase (NOS) isoforms differing in subcellular localization, regulation, and biological function ( Palmer et al. 1988 ). Two constitutively expressed types first characterized in neurons and vascular endothelium are

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