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Giuseppina Mattace Raso Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Giuseppe Bianco Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Anna Iacono Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Emanuela Esposito Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Giuseppina Autore Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Maria Carmela Ferrante Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Antonio Calignano Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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Rosaria Meli Department of Experimental Pharmacology, University of Naples, ‘Federico II’, via D. Montesano, 49-80131 Naples, Italy
Department of Pharmaceutical Sciences, University of Salerno, ‘Federico II’, Naples, Italy
Department of Pathology and Animal Health, University of Naples ‘Federico II’, Naples, Italy

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placenta-derived hypotensor substances, modification of angiotensin–renin system or of endothelium-derived relaxing factors. Confirming previous data in normotensive animals ( Shibata et al. 2004 ), we observed that in SHR, as well as in WKY, the

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Chang-Jiang Li The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Hui-Wen Sun The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Fa-Liang Zhu The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Liang Chen The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Yuan-Yuan Rong The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Yun Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Mei Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No. 107#, Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of China
Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China

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Chemistry 270 26746 –26749. Scott-Burden T & Vanhoutte PM 1994 Regulation of smooth muscle cell growth by endothelium-derived factors. Texas Heart Institute Journal 21 91 –97. Shi Y , O

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Eugen Brailoiu Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Siok L Dun Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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G Cristina Brailoiu Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Keisuke Mizuo Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Larry A Sklar Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Tudor I Oprea Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Eric R Prossnitz Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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Nae J Dun Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Department of Pathology,
Division of Biocomputing, Department of Biochemistry and Molecular Biology and
Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA

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-Reyes G 2000 17Beta-estradiol increases intracellular calcium concentration through a short-term and nongenomic mechanism in rat vascular endothelium in culture. Journal of Cardiovascular Pharmacology 36 196 –202

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Nele Schwarz Centre of Molecular Endocrinology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Centre for Biochemical Pharmacology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Research Centre for Clinical and Diagnostic Oral Sciences, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK

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Derek Renshaw Centre of Molecular Endocrinology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Centre for Biochemical Pharmacology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Research Centre for Clinical and Diagnostic Oral Sciences, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK

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Supriya Kapas Centre of Molecular Endocrinology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Centre for Biochemical Pharmacology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Research Centre for Clinical and Diagnostic Oral Sciences, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK

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Joy P Hinson Centre of Molecular Endocrinology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Centre for Biochemical Pharmacology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK
Research Centre for Clinical and Diagnostic Oral Sciences, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary University, London, UK

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NH 2001 Endothelium in vitro : a review of human vascular endothelial cell lines for blood vessel-related research. Angiogenesis 4 91 –102. Caron K & Smithies O 2000 Extreme hydrops fetalis and cardiovascular

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Mary C Gieske Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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Gi Youn Na Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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Yongbum Koo Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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Misung Jo Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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Thomas E Curry Jr Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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Chemyong Ko Department of Clinical Sciences and Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky, USA
School of Biotechnology and Biomedical Sciences, Inje University, Kimhae, South Korea

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developing follicles, while CD59 is only localized to granulosa and theca cells of developing follicles ( Oglesby et al. 1996 ). In the rat, DAF protein was reported to be present in the endothelium of the ovary ( Spiller et al. 1999 ). DAF provides the

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Nicoletta Di Simone Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Fiorella Di Nicuolo Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Maurizio Sanguinetti Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Roberta Castellani Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Marco D’Asta Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Leonardo Caforio Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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Alessandro Caruso Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy
Department of Microbiology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy

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that the addition of resistin stimulated HUVEC tube formation. This observation is consistent with the increase in endothelial VEGF secretion, identified as an endothelium-specific mitogen and inducer of angiogenesis and of endothelial cell survival

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T C Alba-Loureiro Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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S M Hirabara Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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J R Mendonça Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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R Curi Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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T C Pithon-Curi Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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in diabetic patients. The observed changes in neutrophils include impairment of the following: adhesion to endothelium and migration to the site of inflammation ( Pereira et al. 1987 ), chemotaxis ( Mowat & Baum 1971 ), bactericidal activity ( Tan

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Thomas Willmott Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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Elizabeth C Cottrell Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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pregnancy, largely due to increased activity of the NOS enzymes within the vascular endothelium, under the control of estrogen ( Zullino et al. 2018 ). Impaired production and/or bioavailability of NOS-derived NO has been associated with poor pregnancy

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Trassanee Chatmethakul Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Robert D Roghair Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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H Yamada N Kamata K Kuwaki T Shimada M Osuga J Shionoiri F Yahagi N Kadowaki T Tamemoto H , et al . 1998 Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1

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Alison E Wallace MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Douglas A Gibson MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Philippa T K Saunders MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Henry N Jabbour MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Saunders PTK 2001b Estrogen receptor β, but not estrogen receptor α, is present in the vascular endothelium of the human and nonhuman primate endometrium . Journal of Clinical Endocrinology and Metabolism 86 1370 – 1378 . Cullinan EB Abbondanzo

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